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N/A N=16 Treatment

Effect of Travoprost 0.004% on Retinal Oximetry in Primary Open Angle Glaucoma

Primary Open Angle Glaucoma

Enrolled (actual)
16
Serious AEs
0.0%
Results posted
Jul 2016
Primary outcome: Primary: Blood Oxygenation — 60; 60; 60 percentage of oxygenation

Study Design & Population

Study type
Interventional
Phase
N/A
Interventions
placebo (Drug); travoprost (Drug)
Age
Adult, Older Adult · 45+ yrs
Sex
All
Sponsor
Université de Montréal
Primary completion
Mar 2013

Outcome Measures

OutcomeResultp-value
PRIMARY
Blood Oxygenation
60; 60; 60

Summary

Glaucoma is the second leading cause of blindness among seniors in Canada. It is often associated with an elevated intraocular pressure (IOP), but its exact mechanism is still largely unknown. Some studies have shown a link between glaucoma and changes in the amount of oxygen in the veins of the eye. The study aims to compare the amount of oxygen in ocular veins among three different groups using a spectrophotometer. This instrument is linked to a camera and can measure the quantity of oxygen in the veins using different characteristics of the blood inside. The groups of the study are: patients without glaucoma, patients suspected of glaucoma and patients newly diagnosed with glaucoma. The drug the investigators are using, Travoprost 0.004%, will only be administered to the groups suspected or diagnosed with glaucoma. Travoprost 0.004% is already approved for use in Quebec and is part of standard care. Ten patients will be recruited into each group for a total of 30 patients in this study. All patients for the suspected or diagnosed groups will be recruited from the Jewish General Hospital. Subsequently all testing will be done at the École d'optométrie, Université de Montréal

Eligibility Criteria

Inclusion Criteria

  • good systemic health
  • irido-corneal angle open
  • intraocular pressure more than 18 mmHg

Exclusion Criteria

  • having cardiovascular problem
  • Hypertension or diabetes
  • under systemic medication for high blood pressure
  • had an ocular surgery in the past
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01711177). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.

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