Phase 2
Completed N=35
Does Doxazosin Attenuate Stress-induced Smoking and Improve Clinical Outcomes?
Source: ClinicalTrials.gov NCT01730846 ↗Enrolled (actual)
35
Serious AEs
0.0%
Results posted
Dec 2017
Primary outcomePrimary: Latency (Min) to Initiate Ad-lib Smoking Session — 11.304; 32.128; 27.557; 23.474 minutes
Summary
The purpose of this study is to examine whether doxazosin will attenuate the ability of stress to precipitate smoking lapse behavior in treatment seeking daily smokers. Participants will participate in a smoking cessation attempt after the laboratory sessions.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Latency (Min) to Initiate Ad-lib Smoking Session |
11.304; 32.128; 27.557; 23.474; 26.790; 23.776 | — |
| SECONDARY Number of Cigarettes Smoked During Ad-lib Session |
3.331; 1.890; 1.813; 2.139; 1.866; 1.688 | — |
Eligibility Criteria
Inclusion Criteria
- Ages 18-60
- Able to read and write English
- Smoker
- Motivated to Quit Smoking
Exclusion Criteria
- Any significant current medical conditions that would contraindicate smoking
- Current Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) abuse or dependence of other substances, other than nicotine dependence or alcohol abuse
- Positive test results at intake appointment on urine drug screens for illicit drugs
- Past 30 day use of psychoactive drugs including anxiolytics and antidepressants
- Women who are pregnant or nursing
- Suicidal, homicidal or evidence of current severe mental illness such as schizophrenia, bipolar disorder or major depression, or anxiety disorders
- Participants who have donated blood within the past 6 weeks
- Individuals who are currently taking other medications prescribed for smoking cessation
- Specific exclusions for administration of doxazosin or any alpha blocker
Data sourced from ClinicalTrials.gov (NCT01730846). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.