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Home › Conditions › Smoking

Smoking

Subtypes of Smoking

E-cigarette Use 1 Electronic Cigarette Use 1

4 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Smoking

180 trials tracked for Smoking: 40 in phase 3 or 4 and 8 with published results. The most-cited published study has 183 citations.

180Trials tracked
40Phase 3 & 4
0Recruiting
8With published results
Phase distribution
Phase 4 28 Phase 3 12 Phase 2 23 Phase 1 5 Other / NA 112
  1. Phase 4 A Comparative Effectiveness & Long Term Health Study in Wisconsin Smokers Completed · 183 cited
  2. Phase 4 The END Perioperative Smoking Pilot Study Completed · 62 cited
  3. Phase 3 Smoking Cessation Versus Long-term Nicotine Replacement Among High-risk Smokers Completed · 30 cited
  4. Phase 4 Varenicline for Light Smokers Completed · 27 cited
  5. Phase 4 Smoking Tobacco and Drinking Study Completed · 26 cited
  6. Phase 3 CPT and Smoking Cessation Completed · 10 cited
Show 44 more trials
  1. Phase 4 UW-CTRI Triple Medication Smoking Cessation Study Completed · 2 cited
  2. Phase 3 Optimizing Smoking Cessation for People With HIV/AIDS Who Smoke Completed
  3. Phase 4 Efficacy of Losartan in Preventing Progression of COPD Completed
  4. Phase 4 Transdermal Patch CVD 1000: The Effect of Heat on Nicotine Release From Nicotine Patches in Adult Smokers Completed
  5. Phase 4 Varenicline Light Smoking Pilot Completed
  6. Phase 4 Smartphone Intervention for Smoking Cessation and Improving Adherence to Treatment Among HIV Patients Completed
  7. Phase 4 Mobile Evidence-Based Smoking Cessation for Veterans Living With HIV (MESH) Completed
  8. Phase 4 Testing Integrative Smoking Cessation for HIV Patients Completed
  9. Phase 4 Treating Caregivers Who Smoke at AFCH Completed
  10. Phase 4 Identifying Treatments to Motivate Smokers to Quit Completed
  11. Phase 4 A Study of Varenicline for Prevention of Relapse to Smoking in Patients With Schizophrenia or Bipolar Disorder Completed
  12. Phase 4 Combination Nicotine Replacement for Alcoholic Smokers Completed
  13. Phase 4 Evaluation of National Cancer Institute (NCI) Smoking Intervention Resources Completed
  14. Phase 4 Bio-Behavioral Predictors of the Efficacy of Nicotine Replacement Therapy (NRT) Completed
  15. Phase 4 Long-term Varenicline Treatment for Smoking Cessation Completed
  16. Phase 4 Identifying Optimal Smoking Cessation Intervention Components (Cessation) Completed
  17. Phase 4 Functional Magnetic Resonance Imaging (fMRI) Investigation of Nicotine Withdrawal Symptoms Completed
  18. Phase 4 Improving the Population-Wide Effectiveness of U.S. Tobacco Cessation Quitlines Completed
  19. Phase 4 Pilot Study: Preoperative Nicotine Lozenges Completed
  20. Phase 4 Distribution of Bupropion and Varenicline to Increase Smoking Cessation Attempts Completed
  21. Phase 4 Bupropion SR Plus Counseling for Smoking Cessation Completed
  22. Phase 4 Behaviorally Enhanced Counseling on Nicotine Dependence (BEACON) Trial. Completed
  23. Phase 4 Melatonin in Smoke-induced Vascular Injury Completed
  24. Phase 4 Helping Those With Mental Illness Quit Smoking Completed
  25. Phase 4 Evaluation of Treatments to Improve Smoking Cessation Medication Adherence Completed
  26. Phase 3 Behavioral Activation Intervention, Reward Processing, and Youth Smoking Cessation Completed
  27. Phase 3 Metabolism Informed Smoking Treatment: The MIST RCT Completed
  28. Phase 3 Smoking Termination Enhancement Project (STEP) Completed
  29. Phase 3 Zyban as an Effective Smoking Cessation Aid for Patients Following an Acute Coronary Syndrome: The ZESCA Trial Completed
  30. Phase 3 Varenicline and Bupropion for Smoking Cessation Completed
  31. Phase 3 Efficacy and Safety Study of Nicotine Mint Lozenge (2mg and 4mg) in Smoking Cessation Completed
  32. Phase 3 Varenicline Treatment for Active Alcoholic Smokers Completed
  33. Phase 3 Chantix & Bupropion for Smoking Cessation Completed
  34. Phase 3 Smoking Cessation for Adults With Attention Deficit Hyperactivity Disorder (ADHD) Completed
  35. Phase 2 STARS (Smoking Treatment And Remote Sampling) Study Completed
  36. Phase 2 Efficacy of Naltrexone in Women's Smoking Cessation Completed
  37. Phase 2 Testing Methylphenidate for Smoking Abstinence Completed
  38. Phase 2 Effect of Donepezil on Smoking Completed
  39. Phase 2 St. John's Wort for Tobacco Cessation Completed
  40. Phase 2 Evaluation of the Nicotine Lozenge in Relief of Provoked Acute Craving Completed
  41. Phase 2 The Effect of Naltrexone and Varenicline on Alcohol-Mediated Smoking Lapse Completed
  42. Phase 2 Neuroimaging Reward, Behavioral Treatment, and Smoking Cessation Completed
  43. Phase 2 Modeling Stress-precipitated Smoking Behavior for Medication Development Completed
  44. Phase 2 Message Framing for Telephone Quitline Callers Completed

Showing the 50 most-cited and recently-updated of 180 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

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Supporting pregnant women to quit smoking with counseling or financial help can lead to healthier babies and fewer NICU admissions.
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Outbreak report summarizes patterns and characteristics of vaping-associated lung injury cases
Infectious Disease
Outbreak report summarizes patterns and characteristics of vaping-associated lung injury cases What did we learn from the vaping lung injury outbreak?
An observational outbreak report summarized patterns and characteristics of lung injury cases associated with e-cigarette use across multipl…
A 2019 wave of serious lung injuries swept across the United States, and all the cases had one thing in common: the people affected had used…
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A surveillance report identified 215 possible cases of severe pulmonary disease associated with electronic cigarette use across 25 states.
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CDC Apr 4, 2026