N/A
Completed N=106
Secondary HIV Prevention and Adherence Among HIV-infected Drug Users
Risk Behavior · Medication Adherence · HIV
Source: ClinicalTrials.gov NCT01741311 ↗
Enrolled (actual)
106
Serious AEs
0.0%
Results posted
Aug 2025
Primary outcomePrimary: Number of Participants in Each Condition With Optimal ART Adherence — 27; 29 participants
Summary
This study will test whether 3H+ (Holistic Health for HIV) is comparable to the original HHRP+ (Holistic Health Recovery Program) in reducing HIV risk behaviors and improving ART (Antiretroviral Therapy) adherence in a randomized controlled comparative effectiveness trial among 256 HIV+ persons in drug treatment who report unsafe injection drug use practices or sexual risk behavior.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Number of Participants in Each Condition With Optimal ART Adherence |
27; 29 | — |
| SECONDARY Viral Suppression |
45; 34 | — |
Eligibility Criteria
Inclusion Criteria
- HIV positive
- Opioid dependent and enrolled in methadone maintenance treatment
- Report drug- or sex-related HIV risk behavior in previous 6 months
- Able to read and understand the questionnaires, the Audio Computer Assisted Self Interview (ACASI), and consent form
- Available for the full duration of the study with no anticipated circumstances impeding participation
- Not actively suicidal, homicidal, or psychotic as assessed by trained research staff under the supervision of the PI who is a licensed clinical psychologist in Connecticut.
Exclusion Criteria
-
Data sourced from ClinicalTrials.gov (NCT01741311). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.