N/A N=42 Randomized Treatment

Mommy-Baby Treatment for Perinatal Depression

Depressive Disorder, Major · Postpartum Depression

Bottom Line

View on ClinicalTrials.gov: NCT01744041 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Jan 2022

Primary outcome: Primary: Change in Edinburgh Depression Scale From Baseline — 17.81; 17.9; 12.04; 11.41 units on a scale

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Dyadic Interpersonal Psychotherapy (Behavioral); Enhanced Treatment as Usual (Other)
Age: Adult, Older Adult · 18+ yrs
Sex: Female
Sponsor: Washington University School of Medicine
Primary completion: Jan 2017

Outcome Measures

Outcome	Result	p-value
PRIMARY Change in Edinburgh Depression Scale From Baseline	17.81; 17.9; 12.04; 11.41; 11.0; 10.3	—

Summary

Perinatal depression is a major public health problem, affecting 15% of women during pregnancy through the postpartum period, with adverse consequences for the mother, the fetus, the infant, and the family. Despite increasing evidence of the importance of this critical risk interval, little research has investigated the effects of depression treatment during pregnancy on infant outcomes. The purpose of this study is to test the feasibility, acceptability, and effectiveness of a new intervention, Interpersonal psychotherapy for the mother-infant dyad (IPT-Dyad). This intervention begins during pregnancy and continues with the mother and infant until one year postpartum. The investigators hypothesize that IPT-Dyad will be better than treatment as usual in reducing depressive symptoms, improving psychosocial functioning,increasing parenting self-efficacy, improving infant emotional development, and enhancing mother-infant relationship quality.

Eligibility Criteria

Inclusion Criteria

Pregnant women
18 years and older
between 12 and 30 weeks gestation
Score greater than or equal to 13 on Edinburgh Depression Scale
Structured Clinical Interview (SCID-IV) diagnosis of Major Depressive Disorder, dysthymia, or Depressive Disorder, Not otherwise Specified
English Speaking

Exclusion Criteria

Substance abuse or dependence in past 3 months
Active suicidal or homicidal ideation
Bipolar disorder, psychotic disorder
unstable medical condition or other medical/obstetrical complication
Evidence of severe intimate partner violence
Ongoing psychosocial or pharmacotherapy for depression

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01744041). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.