N/A
N=256
The Clinical Diagnosis Meaning of MIF in Coronary Heart Disease
Coronary Heart Disease
Bottom Line
View on ClinicalTrials.gov: NCT01750502 ↗Enrolled (actual)
256
Serious AEs
0.0%
Results posted
Mar 2015
Primary outcome: Primary: Comparison Between Coronary-artery-disease Group and Non-coronary-artery-disease Group on MIF Concentration — 48.08; 66.79 MIF Concentration,ug/L
Study Design & Population
- Study type
- Observational
- Phase
- N/A
- Interventions
- —
- Age
- Adult, Older Adult · 20+ yrs
- Sex
- All
- Sponsor
- Wenzhou Medical University
- Primary completion
- Nov 2013
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Comparison Between Coronary-artery-disease Group and Non-coronary-artery-disease Group on MIF Concentration |
48.08; 66.79 | — |
| SECONDARY Comparison the Change of MIF Before and After Percutaneous Coronary Intervention （PCI） at the Patients Who Are Acute Coronary Syndromes and Stable Ischemic Heart Disease |
85.51; 85.40; 84.7 | — |
Summary
Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that promote the inflammatory response.In animal studies, it has been found that MIF is released in the ischaemic heart, promoting glucose uptake and protecting the heart from ischaemia-reperfusion injury.The MIF concentration, influenced by age and myocardial ischemia, have different impact on myocardial functional recovery after ischemia.Therefore, the purpose of this experiment is to study the clinical significance of MIF in patients with coronary heart disease.
Eligibility Criteria
Inclusion Criteria
Control group:
- enroll individuals who confirmed by coronary angiography without coronary heart
- The age between 20 and 80 years old.
- Alanine aminotransferase(ALT):10-55U/L, Aspartate aminotransferase(AST):0-60U/L
- Glucose(GLU-S):3.9-6.1mmol/L
- Triglycerides(TRIG): 0.56-1.7mmol/L, cholesterol(CHOL):3.1-5.2mmol/L, High density lipoprotein(HDL):0.78-1.96mmol/L, High density lipoprotein(LDL):2.07-3.1mmol/L
Experimental group:
- enroll individuals who confirmed by coronary angiography for coronary heart
- The age between 20 and 80 years old.
- ALT:10-55U/L,AST:0-60U/L
- GLU-S:3.9-6.1mmol/L
- TRIG:0.56-1.7mmol/L,CHOL:3.1-5.2mmol/L,HDL:0.78-1.96mmol/L,LDL:2.07-3.1mmol/L
Exclusion Criteria
- Inflammatory diseases, such as rheumatoid arthritis,sepsis,asthma and acute respiratory distress syndrome.
- Diabetes
Data sourced from ClinicalTrials.gov (NCT01750502). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.