N/A
Completed N=144
The Difference in Cerebral Oxygenation Between Propofol and Sevoflurane
Cerebral Hypoxia · Postoperative cognitive dysfunction
Source: ClinicalTrials.gov NCT01757561 ↗
Enrolled (actual)
144
Serious AEs
0.0%
Results posted
Sep 2015
Primary outcomePrimary: the Incidence of Intraoperative Desaturation Between Propofol and Sevoflurane General Anesthesia — 17; 6; 6; 0 participants
Summary
the purpose of this study is to investigate whether propofol and sevoflurane have difference effect on cerebral oxygenation .
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY the Incidence of Intraoperative Desaturation Between Propofol and Sevoflurane General Anesthesia |
17; 6; 6; 0 | — |
| SECONDARY the Incidence of Postoperative Cognitive Disfunction(POCD)Between Propofol and Sevoflurane General Anesthesia |
9; 4; 4; 8; 5; 2 | — |
| SECONDARY the Change in the Level of Serum BDNF(Brain-derived Neurotrophic Factor ) Between Propofol and Sevoflurane Anesthesia |
— | — |
| SECONDARY the Change in the Level of Serum s-100β Between Propofol and Sevoflurane Anesthesia |
— | — |
Eligibility Criteria
Inclusion Criteria
- scheduled to take major surgery under general anesthesia over 18 years old classified as ASA class three or less
Exclusion Criteria
- have a diagnosis of cerebrovascular disorder
Data sourced from ClinicalTrials.gov (NCT01757561). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.