Phase 4
N=80
Femoral Versus Adductor Canal Continuous Peripheral Nerve Blocks for Knee Arthroplasty
Postoperative Pain Following Knee Arthroplasty
Bottom Line
View on ClinicalTrials.gov: NCT01759277 ↗Enrolled (actual)
80
Serious AEs
6.3%
Results posted
Feb 2020
Primary outcome: Primary: Hours Until Discharge Readiness — 61; 55 hours
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 4
- Interventions
- Control: Femoral perineural local anesthetic infusion (Drug); Experimental: Adductor Canal perineural local anesthetic infusion (Drug)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- University of California, San Diego
- Primary completion
- Sep 2014
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Hours Until Discharge Readiness |
61; 55 | — |
| SECONDARY Time to Adequate Analgesia |
61.6; 61.0 | — |
| SECONDARY Time Until Independence From Intravenous Analgesics of at Least 12 Hours |
46.1; 47.5 | — |
| SECONDARY Time Until Timed Up and Go Test Achieved |
33.4; 46.8 | — |
| SECONDARY Time Until Ambulation at Least 30 Meters |
40.9; 56.6 | — |
| SECONDARY Pain Level |
4.4; 3.7; 3.7; 3.4; 2.5; 2.8 | — |
| SECONDARY Opioid Consumption |
8.6; 8.0; 0.9; 1.5; 7.2; 8.5 | — |
Summary
Patients typically experience moderate-to-severe pain following knee arthroplasty that is usually treated with a combination of oral and intravenous analgesics and enhanced by continuous peripheral nerve blocks. There are currently two locations to place a perineural catheter to provide analgesia following knee arthroplasty: a femoral nerve catheter and an adductor canal catheter. Both have been demonstrated to be effective following knee arthroplasty. However, it remains unknown if one location is superior to the other; or, more accurately, what the relative benefits are to each technique.
While femoral CPNB has many benefits, one of the challenges of using this technique is that there is a decrease in quadriceps muscle strength which can be a limiting factor for rehabilitation. In contrast, the adductor canal catheter affects only the vastus medialis. This block may lessen block-induced quadriceps weakness following knee arthroplasty compared with a femoral infusion.
The investigators hypothesize that compared with femoral perineural local anesthetic infusion, an adductor canal infusion is associated with a shorter time until four discharge criteria are met: (1) adequate analgesia; (2) independence from intravenous analgesics; (3) ability to ambulate 30 m; and (4) ability to stand, walk 3 m, and return to a sitting position without another's assistance.
Eligibility Criteria
Inclusion Criteria
- primary, unilateral knee arthroplasty
- age ≥ 18 years
- postoperative analgesic plan includes perineural local anesthetic infusion of 48-72 hours
Exclusion Criteria
- morbid obesity as defined by a body mass index >40 (BMI=weight in kg/ [height in meters]
- chronic, high-dose opioid use (greater than 20mg oxycodone-equivalent opioid use daily within the 2 weeks prior to surgery and duration of use >4 weeks)
- history of opioid abuse
- allergy to study medications
- known renal insufficiency (creatinine > 1.5 mg/dL)
- pregnancy
- incarceration
- any known neuro-muscular deficit of the ipsilateral femoral nerve, obturator nerve and/or quadriceps muscle (including diabetic peripheral neuropathy); and inability to ambulate 30 m preoperatively.
Data sourced from ClinicalTrials.gov (NCT01759277). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.