Mode
Text Size
Log in / Sign up
Phase 4 N=80 Randomized Treatment

Femoral Versus Adductor Canal Continuous Peripheral Nerve Blocks for Knee Arthroplasty

Postoperative Pain Following Knee Arthroplasty

Enrolled (actual)
80
Serious AEs
6.3%
Results posted
Feb 2020
Primary outcome: Primary: Hours Until Discharge Readiness — 61; 55 hours

Study Design & Population

Study type
Interventional
Phase
Phase 4
Interventions
Control: Femoral perineural local anesthetic infusion (Drug); Experimental: Adductor Canal perineural local anesthetic infusion (Drug)
Age
Adult, Older Adult · 18+ yrs
Sex
All
Sponsor
University of California, San Diego
Primary completion
Sep 2014

Outcome Measures

OutcomeResultp-value
PRIMARY
Hours Until Discharge Readiness
61; 55
SECONDARY
Time to Adequate Analgesia
61.6; 61.0
SECONDARY
Time Until Independence From Intravenous Analgesics of at Least 12 Hours
46.1; 47.5
SECONDARY
Time Until Timed Up and Go Test Achieved
33.4; 46.8
SECONDARY
Time Until Ambulation at Least 30 Meters
40.9; 56.6
SECONDARY
Pain Level
4.4; 3.7; 3.7; 3.4; 2.5; 2.8
SECONDARY
Opioid Consumption
8.6; 8.0; 0.9; 1.5; 7.2; 8.5

Summary

Patients typically experience moderate-to-severe pain following knee arthroplasty that is usually treated with a combination of oral and intravenous analgesics and enhanced by continuous peripheral nerve blocks. There are currently two locations to place a perineural catheter to provide analgesia following knee arthroplasty: a femoral nerve catheter and an adductor canal catheter. Both have been demonstrated to be effective following knee arthroplasty. However, it remains unknown if one location is superior to the other; or, more accurately, what the relative benefits are to each technique. While femoral CPNB has many benefits, one of the challenges of using this technique is that there is a decrease in quadriceps muscle strength which can be a limiting factor for rehabilitation. In contrast, the adductor canal catheter affects only the vastus medialis. This block may lessen block-induced quadriceps weakness following knee arthroplasty compared with a femoral infusion. The investigators hypothesize that compared with femoral perineural local anesthetic infusion, an adductor canal infusion is associated with a shorter time until four discharge criteria are met: (1) adequate analgesia; (2) independence from intravenous analgesics; (3) ability to ambulate 30 m; and (4) ability to stand, walk 3 m, and return to a sitting position without another's assistance.

Eligibility Criteria

Inclusion Criteria

  • primary, unilateral knee arthroplasty
  • age ≥ 18 years
  • postoperative analgesic plan includes perineural local anesthetic infusion of 48-72 hours

Exclusion Criteria

  • morbid obesity as defined by a body mass index >40 (BMI=weight in kg/ [height in meters]
  • chronic, high-dose opioid use (greater than 20mg oxycodone-equivalent opioid use daily within the 2 weeks prior to surgery and duration of use >4 weeks)
  • history of opioid abuse
  • allergy to study medications
  • known renal insufficiency (creatinine > 1.5 mg/dL)
  • pregnancy
  • incarceration
  • any known neuro-muscular deficit of the ipsilateral femoral nerve, obturator nerve and/or quadriceps muscle (including diabetic peripheral neuropathy); and inability to ambulate 30 m preoperatively.
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01759277). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.

Back to search