Phase 4 N=160 Management of Postoperative Pain After Total Knee Replacement.
Postoperative Pain · Knee Replacement Arthroplasty
Primary: Post-Operative Pain — 2.9; 3.0 units on a scale — p=0.76
Clinical Trial Search
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N/A N=120 Postoperatory Analgesia After Total Knee Arthroplasty
PAIN
Primary: Postoperatory Analgesia After Total Knee Arthroplasty Comparing Femoral and Sciatic-femoral Block — 2; 2.8; 1.5 units on a scale
Phase 2 N=120 Effects of Pregabalin on Pain After Total Knee Arthroplasty
Primary Total Knee Arthroplasty
Primary: Postoperative Pain — 4; 4.8; 4.5; 4.0 units on a scale
N/A N=179 Persistent Postoperative Pain and Joint Stiffness After Total Knee Arthroplasty Performed for Osteoarthritis
Pain · Joint Stiffness
Primary: Presence of Persistent Postoperative Pain Using the Numeric Rating Scale (NRS) — 10 Participants
Phase 2 N=138 Dose-Ranging Study for Prolonged Postoperative Analgesia in Subject Undergoing Total Knee Arthroplasty
Postoperative Pain
Primary: Area Under the Curve (AUC) of the Numeric Rating Scale (NRS) With Activity (NRS-A) Pain Intensity Scores Through Postoperative Day 4 — 20.4; 20.7; 19.5; 18.8 Units on a…
N/A N=100 Ketamine Administration for Postoperative Pain Management in Patients Undergoing Knee Arthroplasty
Knee Arthroplasty · Postoperative Pain · Pain Management
Primary: Total Opioid Consumption in Morphine Equivalents Within 24 Hours After Surgery — 0; 10 mg morphine equivalents (MME)
N/A N=311 Risk Factors and Mechanisms for Persistent Postsurgical Pain After Total Knee Replacement
Persistent Postsurgical Pain
Primary: Number of Subjects With Post-Operative Persistent Pain (PPP) — 211; 34 Participants
Phase 4 N=90 Analgesia After Total Knee Arthroplasty: Peri-Articular Injection Versus Epidural + Femoral Nerve Blockade
Readiness to Discharge
Primary: The Primary Outcome is Time Until a Patient is "Ready for Discharge." — 3.2; 3.2 days
N/A N=60 Postoperative Knee Strength Following Total Knee Replacement: A Double-Blinded Randomized Comparison Study
Total Knee Replacement · Primary Knee Arthroplasty
Primary: Comparison of Postoperative Strength (Extension) — .08; .03; .05 Nm/kg
Phase 3 N=307 Efficacy And Safety Of Pregabalin For Pain Following Total Knee Replacement
Osteoarthritis · Postoperative Pain
Primary: Subject Reported Worst Pain Score in Daily Diaries Using the Worst Pain Item of the Modified Brief Pain Inventory - Short Form (m-BPI-sf) — 7.041; 6.740; 7.079 scores on…
N/A N=40 Femoral/Sciatic Block for Knee Surgery
Knee Injuries
Primary: Analgesic Efficacy — 0; 0.1; 0.6; 3.0 units on a scale — p=<0.05
Phase 4 N=67 The Role of Intra-Operative Intracapsular Blocks in Post-Operative Pain Management Following Total Knee Arthroplasty
Osteoarthritis
Primary: Numeric Pain Score — 0.67; 1.6; 2.5; 3.6 units on a scale — p=<0.05
Phase 4 N=119 Intravenous Acetaminophen for Non-Narcotic Postoperative Pain Management Following Knee Arthroscopy
Pain, Postoperative
Primary: Postoperative Pain Levels — 1.3160; 2.1362 score on a scale
Phase 3 N=48 Ketorolac as an Adjuvant Agent for Postoperative Pain Control Following Arthroscopic Meniscus Surgery
Meniscus Tear, Tibial · Pain, Postoperative · Postoperative Complications
Primary: Pain Levels Recorded With a Visual Analogue Scale — 25.6; 28.8 score on a scale
Phase 4 N=60 A Comparison of Naropin and Ketorolac for Postoperative Analgesia After Total Knee Arthroplasty
Postoperative Pain
Primary: Morphine Consumption — 48.75; 10 mg
N/A N=201 Opiates Prescribing for Knee Arthroscopies and ACL Reconstruction
Knee Injuries · ACL Injury
Primary: Numeric Pain Rating Scale (NPRS) Pain Score — 5.2; 5.3; 5.0; 5.6 score on a scale
N/A N=26 Transcutaneous Electrical Nerve Stimulation After Total Knee Arthroplasty.
Transcutaneous Electric Nerve Stimulation · Pain
Primary: Change in Pain Level From Baseline to 90 Minutes — 3.1; 3.3 Units on a scale
Phase 4 N=102 Efficacy of Multimodal Peri- and Intraarticular Drug Injections in Total Knee Arthroplasty
Osteoarthritis of the Knee
Primary: Pain at Rest (VAS) — 18; 12; 30 Units on a scale — p=0.001
Phase 4 N=42 Dexamethasone and Pain Following Total Knee Arthroplasty
Acute Pain · Chronic Pain
Primary: Change in Visual Analogue Pain Score — 3.09; 4.80; 3.56; 5.5 units on a scale — p=0.052
Phase 3 N=194 Evaluation of Preoperative N1539 in Total Knee Arthroplasty
Pain, Postoperative
Primary: Opioid Use Hour 0-24 — 18.94; 27.73 mg morphine equivalent
N/A N=400 Opioid-free Accelerated Recovery Total Knee Arthroplasty
Arthropathy of Knee Joint
Primary: Number of Patients With Total Knee Replacement Performed Without Opioids Through 12 Weeks Postoperative — 73 Participants
Phase 4 N=50 Pain Control With Total Knee Replacement
Postoperative Pain
Primary: Patient Pain Scores — 33.6; 40.0; 34.9; 46.3 units on a scale- VAS
Phase 4 N=20 Evaluation Exparel Delivered in Knee Replacement
Arthritis
Primary: Subjective Pain — 3.80; 4.00; 3.44; 5.30 units on a scale
Phase 2 N=11 Trigger Point Injection in Reducing Pain Following Total Knee Arthroplasty
Trigger Point Pain, Myofascial
Primary: Pain Scores on the Visual Analog Scale — 51; 55; 40; 42 Pain Scores on the Visual Analog Scale
Phase 4 N=180 Minimal Opioid Use After Total Hip Replacement (THR)
Osteoarthritis, Hip
Primary: Opioid Use — 30; 22.5; 15 Oral Morphine Equivalent (mg)
N/A N=124 Treatment With Iovera° for Total Knee Arthroplasty (TKA) Post-Operative Pain
Total Knee Arthroplasty
Primary: Cumulative Opioid Consumption — 4.8; 6.1 TME — p=0.0841
Phase 4 N=84 Pre vs Post Block in Total Knee Arthroplasty (TKA)
Knee Osteoarthritis · Arthroplasty Complications · Postoperative Pain
Primary: Pain Status as Measured by Numeric Pain Scale — 2; 4.00 score on a scale
N/A N=70 Bupivacaine Liposome Suspension Versus a Concentrated Multi Drug Periarticular Injection
Total Knee Arthroplasty
Primary: Pain Scores (Visual Analog Pain Scores) — 2.6; 3.3 units on a scale
N/A N=60 Adductor Canal Block for Total Knee Arthroplasty
Arthroplasty, Replacement, Knee · Pain, Postoperative
Primary: 10 Meter Walk Test — 38.6; 49.8; 43.3 Seconds
Phase 4 N=40 Genicular Nerve Block for Total Knee Arthroplasty
Post-operative Pain
Primary: Opioid Consumption at 24 Hours Post-op — 22.9; 58.1 milligrams of oral morphine equivalents