Phase 4
N=142
Effect of Single-dose Dexmedetomidine on Airway Reflex in Adult With Oral Intubation After Thyroidectomy
Coughing
Bottom Line
View on ClinicalTrials.gov: NCT01774305 ↗Enrolled (actual)
142
Serious AEs
0.0%
Results posted
Aug 2013
Primary outcome: Primary: Coughing Grade — 0.6; 1.4 units on a scale
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 4
- Interventions
- Dexmedetomidine (Drug); Saline (Drug)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Yonsei University
- Primary completion
- Jan 2013
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Coughing Grade |
0.6; 1.4 | — |
| SECONDARY Emergence Time |
492; 355 | — |
Summary
Coughing during emergence from general anaesthesia may lead to dangerous effects including laryngospasm, detrimental haemodynamic changes. Post-thyroidectomy bleeding occurs in 1-4% of patients, and severe coughing may cause bleeding. Dexmedetomidine, a potent α adrenoreceptor agonist, is theoretically appropriate for reducing airway and haemodynamic reflexes during emergence from anaesthesia.
In this study, we investigated whether intravenous single-dose dexmedetomidine at the end of surgery reduces coughing during extubation after thyroidectomy.
Eligibility Criteria
Inclusion Criteria
- ASA physical status 1 or 2 patients patients scheduled for thyroidectomy
Exclusion Criteria
- Severe cardiovascular disease history of motion sickness active status of upper respiratory infection allergy to dexmedetomidine patients who cannot understand Korean
Data sourced from ClinicalTrials.gov (NCT01774305). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.