Clinical Trial Search

Primary: Lung Volume Initiation — 23.3 % Vital Capacity, relative to EEL

Primary: Peak Expiratory Flow Rate — 4.34; 3.92 Liters of air/second

Primary: Change From Baseline in 24-hour Cough Frequency at 14 Weeks — 17.0; 17.0; 12.6; 10.6 Coughs/hour — p=0.99

Primary: Number of Cough Bouts Over 4-hour Postdose Period — 139.6; 131.3; 126.4 Cough bouts — p=0.216

Primary: Brainstem Neural Activations to Capsaicin — 0.09; 0.39; -0.14; 0.44 Percentage change in BOLD signal — p==0.0028

Primary: Number of Coughs — 7.3 Coughs — p=<0.01

Primary: Leicester Cough Questionnaire — 9.04; 8.86; 12.78; 9.44 Total LCQ Score — p=.014

Primary: Leicester Cough Questionnaire (LCQ) — 3.2; 2.06 score on a scale — p=.23

Primary: Total Cough Count Over 8 Hours at Visits 1, 2 and 3 (Part A) — 152.7; 192.5 cough count

Primary: Cough Frequency Measurement — 6.6; 2.7; 2.5; 12.7 coughs per hour over a 24 hour monitorin

Primary: Number of Coughs Following Capsaicin Inhalation Challenge at Baseline and Following 30 Days of Treatment With Spiriva (Baseline and 30 Days) — 2.5 coughs per dose of…

Primary: Change in Cough Reflex Sensitivity (Log C5) — -0.29; 0.24 log C5

Primary: Change in Leicester Cough Questionnaire Score — 6.61; 2.07 score on a scale

Primary: Model-Based Geometric Mean Ratio (GMR) of 24-hour Objective Coughs Per Hour (Week 12/Baseline) — 0.47; 0.48; 0.38 ratio — p=0.041

Primary: Part A: Cough Frequency Per Hour, Assessed Objectively Over 24 Hours Using VitaloJAK® Cough Recorder — 14.88; 17.30; 12.61; 13.21 coughs/hour

Primary: Change From Baseline in Awake Objective Cough Frequency After 12 Weeks of Treatment (Day 84) — -0.40; -0.64; -0.65; -0.86 log coughs/hour — p=0.0971

Primary: Maximum Expiratory Pressure — 104.31 cm H2O (pressure measurement) — p=.001

Primary: Model-Based Geometric Mean Ratio (GMR) of 24-Hour Coughs Per Hour at Week 24/Baseline — 0.43; 0.43; 0.37 Ratio — p=0.875

Primary: Effectiveness of Expiratory Muscle Activation to Generate Large Airway Pressures Characteristic of Normal Cough. — 25; 121 cmH2O — p=<0.05

Primary: Model-Based Geometric Mean Ratio (GMR) of 24-Hour Coughs Per Hour at Week 24 — 0.47; 0.51 Ratio — p=0.713

Primary: Change From Baseline in Awake Cough Frequency After 8 Weeks of Treatment. — -7.5; -16.9; -18.5; 0.3 Coughs/hour

Primary: Change From Baseline in Overall Exacerbations of Chronic Pulmonary Disease Tool-Respiratory Symptoms (E-RS) Total Score Over the 8 Week Study Period — -1.75; -0.73 Score…

Primary: Change From Baseline in the Leicester Cough Questionnaire (LCQ) Total Score at Week 12 — 4.34; 3.59 Scores on a Scale — p=0.034

Primary: Sensitivity of Detecting SARS-CoV-2 RNA — 31; 0 Participants

Primary: Change in 24-hour Objective Cough Frequency (Log Normalized Percent Change Relative to Placebo) — -0.18; -0.45 coughs/hr — p=0.9942

Primary: The Effects of Electrical Spinal Cord Stimulation (SCS) on Airway Pressure Generation While Using Temporarily Placed Parallel Wire Leads and Implanted Disc Electrodes…

Primary: Number of Subjects With Serious Adverse Events — 0; 0 Participants

Primary: Percent Change in Number of Coughs Per Hour in 24 Hours Following 4 Weeks of Study Treatment — -55.16; -61.08; -65.32; -60.38 percentage change — p=0.9334

Primary: Change From Baseline in Daytime Objective Cough Frequency — -0.5365; 0.0523 Coughs/hour — p=0.0003

Primary: Change From Baseline in 24-hour Cough Count After 12 Weeks of Intervention — 0.56; 0.47; 0.52; 0.64 Ratio btw geoMeans of 24h cough count — p== 0.0345