Phase 3
Completed N=523
PreHospital Air Medical Plasma Trial
Hemmorhagic Shock During Air Medical Transport
Source: ClinicalTrials.gov NCT01818427 ↗
Enrolled (actual)
523
Serious AEs
0.6%
Results posted
Oct 2018
Primary outcomePrimary: Our Primary Outcome for the Proposal Will be 30 Day Mortality — 53; 89 Participants
◆ Published Evidence
Highly cited
303citations · ~51 / year
Association of Prehospital Plasma Transfusion With Survival in Trauma Patients With Hemorrhagic Shock When Transport Times Are Longer Than 20 Minutes: A Post Hoc Analysis of the PAMPer and COMBAT Clinical Trials.
Summary
To determine the effect of the prehospital infusion during air transport of 2 units of AB plasma on 30 day mortality in patients with hemorrhagic shock as compared to conventional care.
Linked Publications (5)
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Association of Prehospital Plasma Transfusion With Survival in Trauma Patients With Hemorrhagic Shock When Transport Times Are Longer Than 20 Minutes: A Post Hoc Analysis of the PAMPer and COMBAT Clinical Trials.
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Association of Prehospital Plasma With Survival in Patients With Traumatic Brain Injury: A Secondary Analysis of the PAMPer Cluster Randomized Clinical Trial.
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Prehospital plasma is associated with distinct biomarker expression following injury.
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High Dimensional Multiomics Reveals Unique Characteristics of Early Plasma Administration in Polytrauma Patients With TBI.
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Characterization of adverse events in injured patients at risk of hemorrhagic shock: a secondary analysis of three harmonized prehospital randomized clinical trials.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Our Primary Outcome for the Proposal Will be 30 Day Mortality |
53; 89 | — |
| SECONDARY Twenty Four-Hour Blood Transfusion Requirements |
3; 4 | — |
| SECONDARY In-hospital Mortality |
51; 88 | — |
| SECONDARY Multiple Organ Failure |
145; 156 | — |
| SECONDARY Acute Lung Injury (ALI) and Transfusion Related Acute Lung Injury (TRALI) |
48; 50 | — |
Eligibility Criteria
Inclusion Criteria: Hemorrhagic shock not responsive to crystalloid infusion -
Exclusion Criteria: Isolated Fall, Cervical cord injury, prisoner, pregnant patient, traumatic arrest
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Data sourced from ClinicalTrials.gov (NCT01818427) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.