Phase 3 N=523 PreHospital Air Medical Plasma Trial
Hemmorhagic Shock During Air Medical Transport
Primary: Our Primary Outcome for the Proposal Will be 30 Day Mortality — 53; 89 Participants
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Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=76 Thrombolytic Care During Inter-hospital Transfer
Stroke
Primary: Percentage of Participants With a rtPA Protocol Violation — 7; 0 Participants
Phase 3 N=903 Study of Tranexamic Acid During Air and Ground Medical Prehospital Transport Trial (STAAMP Trial)
Traumatic Hemorrhage
Primary: 30 Day Mortality — 36; 45 Participants
Phase 2 N=191 Field Trial of Hypotensive Versus Standard Resuscitation for Hemorrhagic Shock After Trauma
Blunt Trauma · Penetrating Wound · Hemorrhagic Shock
Primary: Total Volume of All Crystalloid Given for Early Resuscitation (Feasibility) — 2.04; 1.04; 1 liters
N/A N=1,051 Shock, Whole Blood, and Assessment of TBI S.W.A.T. (LITES TO 2)
Hemorrhagic Shock · Traumatic Brain Injury
Primary: 4 Hour Mortality — 50; 32 Participants
N/A N=5 Biological Response of Trauma Patients to Standard Trauma Resuscitation Therapy
Hemorrhagic Shock
Primary: Biological Response as Characterized by Selected Cytokines, Specifically Tumor Necrosis Factor Alpha (TNFα), Interleukin One (IL-1β), and Interleukin Six (IL-6).
Phase 2 N=101 AVERT Shock: Arginine Vasopressin During the Early Resuscitation of Traumatic Shock
Traumatic Shock
Primary: Number of Blood Products Transfused — 1.7; 3.0 Litre
N/A N=50 Pre-hospital Advanced Therapies for Control of Hemorrhage - Pelvis
Hemorrhage · Pelvic Fracture
Primary: Mortality Rate — 0; 1 Participants
Phase 2 N=1,063 Prehospital Tranexamic Acid Use for Traumatic Brain Injury
Traumatic Brain Injury
Primary: Dichotomized Glasgow Outcome Scale Extended (GOS-E) at 6 Months — 107; 108; 110; 218 Participants — p=.1809
N/A N=50 Effect of Remote Ischemic Conditioning on Trauma Patients With Hemorrhagic Shock
Hemorrhagic Shock
Primary: Neutrophil Oxidative Burst Activity — 302; 302; 298; 268 Median Fluorescence Intensity — p=0.56
Phase 2 N=200 Cold Stored Platelet in Hemorrhagic Shock
Trauma · Hemorrhage
Primary: Study Feasibility — 91; 82 Participants
N/A N=100 Extending Acute Stroke Trials to the Aerial Inter-hospital Transfer Setting
Stroke
Primary: The Benefit of Advanced Notification in Promoting Informed Consent — 27; 25 Participants
N/A N=100 The Effect of the Hemobag® Ultrafiltration System on Blood Conservation and Coagulation After Cardiopulmonary Bypass
Blood Coagulation Disorders
Primary: Amount of Chest Catheter Drainage 24 Hours Postoperatively — 766; 626 mL
Phase 4 N=43 Analgesics in the Pre-hospital Setting: Implications on Hemorrhage Tolerance - Ketamine
Hemorrhage · Healthy
Primary: Cumulative Stress Index — 635; 649 mmHg x minutes
Phase 3 N=1,604 Early Use of Cryoprecipitate With Major Hemorrhage Protocol (MHP) Activation
Trauma Injury
Primary: Number of Participants With Mortality From Any Cause — 201; 192 Participants
N/A N=95 Heart Rate Variability in Trauma Patients
Trauma
Primary: Base Deficit </= -6 — 12 participants
Phase 3 N=199 Low-Titer O Positive Whole Blood Versus Component Therapy for Emergent Transfusion in Trauma Patients
Hemorrhagic Shock · Acute Blood Loss Anemia · Traumatic Brain Injury
Primary: Packed Red Blood Cells Equivalents Units Transfused (1 Whole Blood Unit Treated as 1 Packed Red Blood Cell Unit and 1 Fresh Frozen Plasma Unit) — 3.8; 5.7 units
Phase 2 N=44 Analgesics in the Pre-hospital Setting: Implications on Hemorrhage Tolerance - Morphine
Healthy
Primary: Tolerance to Simulated Hemorrhage — 385; 692 CSI: Cumulative Stress Index
Phase 2 N=38 Analgesics in the Pre-hospital Setting: Implications on Hemorrhage Tolerance - Fentanyl
Healthy
Primary: Cumulative Stress Index — 647; 676 mmHg x minutes
Phase 2 N=2 Washington Study of Hemofiltration After Out-of-Hospital Cardiac Arrest
Cardiac Arrest
Primary: Intervention Compliance — 1 participants
Phase 4 N=107 Early Whole Blood in Patients Requiring Transfusion After Major Trauma
Trauma/Injury Problem
Primary: Units of Blood Products Required During the First 24 Hours After Emergency Department Admission — 12; 13 units of blood
N/A N=380 Evaluation of Non-Invasive Hemoglobin in Trauma Patients
Trauma
Primary: SpHb's Ability to Detect Critical Drops
Phase 2 N=50 Resuscitative Endocrinology: Single-dose Clinical Uses for Estrogen-Traumatic Hemorrhagic Shock (RESCUE - Shock)
Hemorrhagic Shock
Primary: Survival — 16; 21 participants — p=.252
N/A N=101 California Transport Cooling Trial
Hypoxic Ischemic Encephalopathy
Primary: Percentage of Temperatures in Target Range During Transport — 0; 73 Percentage of temperatures — p=<0.001
N/A N=165 Hypoxemia in the First 24 Hours After Trauma - an Observational Study
Trauma · Trauma Injury · Hypoxemia
Primary: Occurrence of Hypoxemia — 5.1; 5.1 IR of episodes pr. 100 participant-hours — p=0.95
Phase 4 N=337 Preventing Cardiovascular collaPse With Administration of Fluid Resuscitation Before Endotracheal Intubation
Acute Respiratory Failure · Intubation Complication
Primary: Number of Participants With Cardiovascular Collapse — 33; 31 Participants
N/A N=5 Pre-hospital ECMO in Advanced Resuscitation in Patients With Refractory Cardiac Arrest. ( SUB30 )
Death, Sudden, Cardiac · Out-Of-Hospital Cardiac Arrest · Ventricular Fibrillation
Primary: Proportion of Patients Successfully Established With Pre-hospital ECPR — 0 Participants
Phase 4 N=50 ECMO Hemostatic Transfusions in Children
Extracorporeal Membrane Oxygenation Complication · Hemorrhage · Thromboembolism
Primary: Total Platelet Transfusion Dose — 7.4; 0 mL/kg/day
Phase 2 N=31 Traumatic Injury Clinical Trial Evaluating Tranexamic Acid in Children: A Pilot and Feasibility Study
Brain Injuries · Wounds and Injuries · Hemorrhage
Primary: Pediatric Quality of Life Inventory (PedsQL) — 64.9; 60.2; 67.2 Quality of life units * months
N/A N=48 Hemodynamic Effects of Standard Cardiopulmonary Resuscitation (CPR), Active Compression Decompression CPR With an Inspiratory Impedance Device, and Standard CPR With an Intrathoracic Pressure Regulator During Out-of-hospital Cardiac Arrest
Cardiac Arrest · Sudden Cardiac Death
Primary: Mean Systolic and Diastolic Blood Pressures — 80.38; 121.21; 61.37; 15.52 mmHg