N/A
Completed N=52
Risky Decision Making in Methamphetamine Users: The Role of Opioid Blockade
Methamphetamine Abuse · HIV
Source: ClinicalTrials.gov NCT01822132 ↗
Enrolled (actual)
52
Serious AEs
0.0%
Results posted
Feb 2019
Primary outcomePrimary: Discounting Tasks: Sexual Probability Discounting (SexPD) — 2.97; 6.52; 4.68; 7.67 natural log
Summary
The purpose of this protocol is to learn more about impulsive decision making in people who use methamphetamines. The investigators would like to know if a medication called naltrexone changes how people make decisions. The investigators would also like to know whether changes in decision making can be observed by MRI (magnetic resonance imaging).
The research is conducted in Portland, OR.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Discounting Tasks: Sexual Probability Discounting (SexPD) |
2.97; 6.52; 4.68; 7.67; -0.54; 1.08 | — |
| PRIMARY Discounting Tasks: Standard Delay Discounting (DD) |
-2.92; -3.90; -2.73; -4.25; -5.44; -5.56 | — |
| PRIMARY Barrat Impulsiveness Scale (BIS) |
77.5; 73.52; 71.79; 63.30; 70.83; 61 | — |
| PRIMARY Risk Assessment Battery (RAB) |
1.33; 0.6; 0.24; 0.08; 5.48; 4.44 | — |
| SECONDARY Methamphetamine Use |
1.33; 2.17; 1.17; 1.6; 1.4; 0.13 | — |
Eligibility Criteria
Summary Inclusion Criteria:
- Diagnostic and Statistical Manual (DSM)-IV Methamphetamine Dependence
- Deemed healthy enough to participate by study physician
- Age 18-55
- Right handed
- English-speaking
Summary Exclusion Criteria:
- Current opioid use in the last 30 days; opioid abuse or dependence within past 5 years
- Pregnancy
- MRI contraindications (e.g. metal in head).
The research is conducted in Portland, OR.
Data sourced from ClinicalTrials.gov (NCT01822132). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.