N/A
Completed N=90
Effects of CPAP on Visceral Fat Thickness
Source: ClinicalTrials.gov NCT01828281 ↗Enrolled (actual)
90
Serious AEs
0.0%
Results posted
Nov 2015
Primary outcomePrimary: Mesenteric Fat Thickness — 0.96; 0.94 cm
Summary
We hypothesize that patients with untreated OSAS will have more visceral fat, fatty liver and increased carotid artery thickness whereas treatment with CPAP may reduce the mesenteric and liver fat, plasma lipids, carotid artery thickness.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Mesenteric Fat Thickness |
0.96; 0.94 | — |
| SECONDARY Mean Changes in Adiponectin Over 3 Months |
23.63; 29.78 | — |
Eligibility Criteria
Inclusion Criteria
- symptomatic patients with OSA of apnea hypopnea index (AHI) >= 5/hr
Exclusion Criteria
- Recent or past history of myocardial infarction/stroke/heart failure, unstable angina, underlying malignancy,
- patients with clinical features of any active infection
- those who require urgent CPAP treatment because of associated respiratory failure or to prevent job loss through excessive daytime sleepiness (eg professional drivers, those handling dangerous machinery)
- moderate to severe valvular heart disease, cardiomyopathy, and previous diagnosis of OSA and/or previous use of CPAP therapy.
Data sourced from ClinicalTrials.gov (NCT01828281). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.