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Obstructive Sleep Apnea

Part of Sleep Disorders, Intrinsic

28 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Obstructive Sleep Apnea

229 trials tracked for Obstructive Sleep Apnea: 28 in phase 3 or 4 and 10 with published results. The most-cited published study has 628 citations.

229Trials tracked
28Phase 3 & 4
0Recruiting
10With published results
Phase distribution
Phase 4 11 Phase 3 17 Phase 2 27 Phase 1 6 Other / NA 168
  1. Phase 3 Obstructive Sleep Apnea Master Protocol GPIF: A Study of Tirzepatide (LY3298176) in Participants With Obstructive Sleep Apnea Completed · 628 cited
  2. Phase 3 "A Long-Term Safety Study of JZP-110 in the Treatment of Excessive Sleepiness in Subjects With Narcolepsy or OSA" Completed · 249 cited
  3. Phase 3 "Six-week Study of the Safety and Efficacy of JZP-110 in the Treatment of Excessive Sleepiness in OSA" Completed · 81 cited
  4. Phase 3 "Twelve-week Study of the Safety and Efficacy of JZP-110 in the Treatment of Excessive Sleepiness in OSA" Completed · 40 cited
  5. Phase 4 The Impact of Arousal Threshold in Obstructive Sleep Apnea Completed · 28 cited
  6. Phase 4 The Impact of Venlafaxine on Apnea Hypopnea Index in Obstructive Sleep Apnea Completed · 21 cited
Show 44 more trials
  1. Phase 3 Steroids for Pediatric Apnea Research in Kids Completed · 20 cited
  2. Phase 3 Montelukast and Inhaled Nasal Steroid Tx in Adult Obstructive Sleep Apnea (OSA) Completed · 19 cited
  3. Phase 4 Solriamfetol's Effect on Cognitive Health in Apnea Participants During a Randomized Placebo-controlled Study Completed · 9 cited
  4. Phase 4 Treatment of OSA Associated Hypertension With Alpha 2 Agonist or Diuretic Completed · 8 cited
  5. Phase 4 Effect of Ketorolac on Post Adenotonsillectomy Pain Completed
  6. Phase 4 Impact of Sugammadex vs. Neostigmine Reversal on Post-Operative Recovery and Complications Completed
  7. Phase 4 Applying Best Clinical Practices to Patients at High Risk of Respiratory Complications Completed
  8. Phase 4 The Effects of Mometasone Furoate Nasal Spray in Subjects With Sleep-disordered Breathing (SDB) Associated With Perennial Allergic Rhinitis (Study P04726) Completed
  9. Phase 4 Dexmedetomidine and Propofol in Children With History of Obstructive Sleep Apnea Completed
  10. Phase 4 Trial of Effects of Oral Xyrem and Zolpidem on Sleep-Disordered Breathing in Obstructive Sleep Apnea Patients Completed
  11. Phase 4 Efficacy and Safety of Armodafinil for Adults With Excessive Sleepiness Obstructive Sleep Apnea/Hypopnea and Depression Completed
  12. Phase 3 Decrease Emergence Agitation and Provide Pain Relief for Children Undergoing Tonsillectomy & Adenoidectomy Completed
  13. Phase 3 PMP-300E (Smart Watch): Portable Monitoring Device Study Completed
  14. Phase 3 Treatment of Insomnia in Elderly Sleep Apnea Patients With Ramelteon (TAK 375) Completed
  15. Phase 3 Obstructive Sleep Apnea (OSA), Sleepiness, and Activity in Diabetes Management Completed
  16. Phase 3 Armodafinil (CEP-10953) in Treatment of Excessive Sleepiness Associated With Obstructive Sleep Apnea/Hypopnea (OSA/H) Syndrome Completed
  17. Phase 3 Armodafinil (CEP-10953) for Treatment of Narcolepsy, Obstructive Sleep Apnea/Hypopnea Syndrome, or Chronic Shift Work Sleep Disorder Completed
  18. Phase 3 Effect of Liraglutide in Obese Subjects With Moderate or Severe Obstructive Sleep Apnoea: SCALE™ - Sleep Apnoea Completed
  19. Phase 3 Armodafinil (CEP-10953) in Treatment of Excessive Sleepiness Associated With Obstructive Sleep Apnea/Hypopnea Syndrome(OSAHS) Completed
  20. Phase 3 Stimulation Therapy for Apnea Reduction (Www.theSTARtrial.Com) Completed
  21. Phase 3 Brain Oxygenation and Hemodynamics During Sleep in Obstructive Sleep Apnea Sufferers Completed
  22. Phase 3 Diagnosis and Treatment of Sleep Apnea in Cerebrovascular Disease Completed
  23. Phase 2 The Effect of Caffeine on Postextubation Adverse Respiratory Events in Children With Obstructive Sleep Apnea (OSA). Completed
  24. Phase 2 Effect of Desipramine on Genioglossus Muscle Activity in Healthy Adults Study A Completed
  25. Phase 2 Propranolol for Sleep Apnea Therapy Completed
  26. Phase 2 Pharmacological Activation of HMN for OSA Completed
  27. Phase 2 Stroke and CPAP Outcome Study: A Sham-controlled Trial of CPAP Among Stroke Rehabilitation Patients Completed
  28. Phase 2 Impact of Oxytocin on Obstructive Sleep Apnea Induced Changes in Sleep Completed
  29. Phase 2 Safety and Efficacy Study of Dronabinol to Treat Obstructive Sleep Apnea Completed
  30. Phase 2 Tiagabine to Enhance Slow Wave Sleep in Patients With Sleep Apnea Completed
  31. Phase 2 Combination Drug-Therapy for Patients With Untreated Obstructive Sleep Apnea Completed
  32. Phase 2 Effect of Desipramine on Upper Airway Collapsibility and Genioglossus Muscle Activity in Patients With Obstructive Sleep Apnea - Study B Completed
  33. Phase 2 Crossover Trial of AD036 in Obstructive Sleep Apnea Completed
  34. Phase 2 Pediatric Pain Optimization After Tonsillectomy Completed
  35. Phase 2 Apnea, Bariatric Surgery Versus Continuous Positive Airway Pressure (CPAP) Trial Completed
  36. Phase 2 Medications for Obstructive Sleep Apnea In Children With Down Syndrome Completed
  37. Phase 2 The Use of Heliox in Obstructive Sleep Apnea Syndrome Completed
  38. Phase 2 Effects of Treatment of Sleep Apnea on Metabolic Syndrome Completed
  39. Phase 2 Study for Efficacy and Dose Escalation of AD313 + Atomoxetine (SEED) Completed
  40. Phase 2 Sleep Apnea Treatment With Expiratory Resistance(Provent™) Completed
  41. Phase 2 Vascular Impairment in Type II Diabetes Mellitus With Co-morbid Obstructive Sleep Apnea Completed
  42. Phase 2 Trial of AD036 in Obstructive Sleep Apnea Completed
  43. Phase 2 Dimethyl Fumarate for Obstructive Sleep Apnea Completed
  44. Phase 2 Crossover Trial of AD109 in Obstructive Sleep Apnea Completed

Showing the 50 most-cited and recently-updated of 229 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Research across Sleep Disorders, Intrinsic

Related studies from across the Sleep Disorders, Intrinsic family.

Preoperative comorbidities linked to reduced weight loss after metabolic and bariatric surgery in adults
Nutrition & Obesity Medicine Meta-analysis
Preoperative comorbidities linked to reduced weight loss after metabolic and bariatric surgery in adults Pre-existing health conditions may slightly reduce weight loss after surgery
A meta-analysis of twenty-three studies reveals that mental illness, diabetes, and sleep apnea are associated with slightly lower weight los…
Adults with mental illness or diabetes before surgery saw slightly less weight loss. Other conditions like high blood pressure did not affec…
Adenotonsillectomy with turbinate ablation shows no added benefit for pediatric SDB
Pediatrics RCT
Adenotonsillectomy with turbinate ablation shows no added benefit for pediatric SDB Submucosal ablation adds little benefit to adenotonsillectomy for children
This randomized prospective study compared adenotonsillectomy with submucosal ablation of turbinates (AT with SAT) versus AT alone in 51 chi…
A small study found no significant difference in nasal quality of life between children receiving adenotonsillectomy alone versus those also…
Umbrella review identifies risk factors and protective factors for male infertility and semen quality
Nutrition & Obesity Medicine Meta-analysis
Umbrella review identifies risk factors and protective factors for male infertility and semen quality New study lists many things that hurt male fertility and health
This umbrella review of 43 studies synthesizes evidence on risk factors for male infertility and abnormal semen parameters.
A new review shows that obesity, smoking, and certain illnesses can hurt sperm, but healthy habits might fix the problem.
Systematic review and meta-analysis shows Tai Chi improves sleep quality in cancer patients
Neurology Meta-analysis
Systematic review and meta-analysis shows Tai Chi improves sleep quality in cancer patients Gentle Movement Helps Cancer Patients Rest Better Tonight
This systematic review and meta-analysis evaluated the effect of Tai Chi on sleep quality in cancer patients.
Cancer patients struggling with insomnia may find relief through gentle Tai Chi movements that improve sleep quality significantly.
Review finds bed partners have more sleep apnea than pregnant co-sleepers in third trimester
OB/GYN & Women's Health
Review finds bed partners have more sleep apnea than pregnant co-sleepers in third trimester Pregnant women sleep better than their partners despite restlessness
This review of an observational study examined sleep physiology in 41 pregnant participants and 36 bed partners.
Healthy pregnant women sleep better than their bed partners, who face a much higher risk of severe sleep apnea during this time.
Meta-analysis identifies shared genetic loci between cannabis use and sleep disorders
Genetics & Precision Medicine Meta-analysis
Meta-analysis identifies shared genetic loci between cannabis use and sleep disorders Your Brain on Cannabis and Sleep: The Hidden Link
This meta-analysis of All of Us and UK Biobank cohorts investigated genetic correlations between cannabis use and sleep disorders.
Shared genes link cannabis use and sleep problems like insomnia, revealing why millions self-medicate and pointing to new treatment paths.
ASVmv reduces nocturnal hypoxemic burden in AMI patients with sleep-disordered breathing
Radiology & Imaging RCT
ASVmv reduces nocturnal hypoxemic burden in AMI patients with sleep-disordered breathing Early study links sleep treatment to less oxygen drop in heart attack patients
This ancillary analysis of a randomized controlled trial in 35 patients with first-time AMI and sleep-disordered breathing found that minute…
A new ventilator treatment for sleep apnea significantly reduced dangerous oxygen drops in heart attack patients, potentially limiting heart…
Meta-analysis finds global glymphatic impairment in sleep disorders versus healthy controls
Neurology Meta-analysis
Meta-analysis finds global glymphatic impairment in sleep disorders versus healthy controls Your brain needs to clean itself while you sleep
This meta-analysis of 2,315 patients with sleep disorders and healthy controls synthesized evidence on glymphatic function, measured by DTI-…
A new analysis of over 2,300 people finds that a wide range of sleep disorders share a common problem: a broken brain cleanup system.
Ten-week Baduanjin exercise improved sleep and mood in college students with Qi-deficiency constitution
Psychiatry RCT
Ten-week Baduanjin exercise improved sleep and mood in college students with Qi-deficiency constitution Could a gentle 10-week exercise routine help college students feel less anxious and sleep better?
This small randomized study enrolled 37 college students with Qi-deficiency constitution and sleep problems, assigning 18 to control and 19 …
Many college students struggle with sleep and anxiety, often feeling a sense of low energy or weakness.
Diary intervention improves sleep and reduces stress in critically ill children and their parents
Psychiatry RCT
Diary intervention improves sleep and reduces stress in critically ill children and their parents Could a simple diary help critically ill children sleep better and reduce family stress?
A single-blind randomized controlled trial of 94 PICU patient-parent dyads found that a diary intervention significantly improved children's…
A simple diary helped critically ill children sleep better and reduced anxiety and depression in their parents for months after leaving the …
Machine-learning models for sleep stage and respiratory event detection showed performance comparable to expert scorers in healthy and suspected sleep-disordered breathing participants
Neurology
Machine-learning models for sleep stage and respiratory event detection showed performance comparable to expert scorers in healthy and suspected sleep-disordered breathing participants Can computer programs match human experts at reading your sleep data?
This study evaluated machine-learning models for sleep stage classification, arousal detection, and respiratory event detection using overni…
Smart computer models can match human experts at reading sleep data for stages and wake-ups, though they still lag behind humans when spotti…
Sleep Problems Associated With Impaired Gait Quality and Higher Fall Risk in Older Adults
Geriatrics & Aging
Sleep Problems Associated With Impaired Gait Quality and Higher Fall Risk in Older Adults Older adults reporting sleep problems had poorer walking quality and more falls in study
An observational study of 758 community-dwelling older adults found self-reported sleep problems were associated with lower daily-life gait …
Older adults with sleep trouble walked less steadily and fell nearly 50% more often than those who slept well, according to a new study.

Questions about Obstructive Sleep Apnea

Is obstructive sleep apnea linked to muscle loss or sarcopenia in older adults?

Research confirms that obstructive sleep apnea is linked to sarcopenia, or muscle loss, specifically in older adults, with the risk increasing with age and disease severity.

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Which treatment works best for lowering apnea-hypopnea index in obstructive sleep apnea patients?

CPAP produces the largest reduction in apnea-hypopnea index (AHI), while GLP-1 medications improve weight and metabolic health in OSA patients.

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Do people with obstructive sleep apnea have different brain fluid flow than healthy controls?

Yes, people with obstructive sleep apnea show impaired brain fluid flow (glymphatic dysfunction) compared to healthy controls, as measured by MRI-based markers.

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Is tirzepatide a better cost-effective weight loss option than semaglutide for obstructive sleep apnea?

A 2025 simulation study found tirzepatide cost-effective vs semaglutide for obesity, including OSA risk, but no direct cost comparison for OSA alone exists.

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Can childhood asthma make a person more likely to develop obstructive sleep apnea later?

Yes, childhood asthma is linked to a higher risk of developing obstructive sleep apnea later, with studies showing about 66% increased odds.

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See all 5 questions about Obstructive Sleep Apnea →

All Obstructive Sleep Apnea Articles