N/A
N=12
Lactic Acidosis During and After Seizures
Epilepsy
Bottom Line
View on ClinicalTrials.gov: NCT01833247 ↗Enrolled (actual)
12
Serious AEs
0.0%
Results posted
May 2017
Primary outcome: Primary: Salivary Lactic Acid Levels With Seizures — 8.16 mmol/L
Study Design & Population
- Study type
- Observational
- Phase
- N/A
- Interventions
- —
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Stanford University
- Primary completion
- Dec 2014
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Salivary Lactic Acid Levels With Seizures |
8.16 | — |
| PRIMARY Capillary Lactic Acid Levels With Seizures |
5.67 | — |
| PRIMARY Intravenous Lactic Acid Levels With Seizures |
8.6 | — |
Summary
This project looks at the time course of lactic acid rise (if any) after seizures. Salivary and capillary lactic acid are tested. This type of measurement may be useful in signalling the occurrence or recent history of a seizure.
Eligibility Criteria
Inclusion Criteria
- Age 18-75 inclusive.
- History of at least one generalized tonic-clonic (grand mal) seizure prior to enrollment in the study.
- Undergoing monitoring in the Stanford Epilepsy Monitoring Unit.
Exclusion Criteria
- Not pregnant.
- Inability to understand and sign the consent form.
- No known history of mitochondrial disease or other metabolic disorders expected to affect blood lactate.
- No known history of thrombophlebitis or excessive tendency to bleeding. Not on coumadin. Aspirin or anti-platelet agents are not an exclusion.
- No known peripheral vascular disease affecting blood circulation to the fingers.
- No painful peripheral neuropathy.
- No Raynaud's disease or phenomenon.
Data sourced from ClinicalTrials.gov (NCT01833247). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.