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Home › Conditions › Epilepsy

Epilepsy

Subtypes of Epilepsy

Focal epilepsy 5 Developmental and Epileptic Encephalopathies 3 Partial-Onset Seizures 3 Dravet syndrome 2 Functional seizures 2 Infantile epileptic spasms syndrome 2 Nonconvulsive status epilepticus 2 Temporal lobe epilepsy 2 Epilepsy related to fever sensitivity 1 Epilepsy with myoclonic-atonic seizures 1 Generalized epilepsy 1 Generalized epilepsy with febrile seizures plus 1 Genetic epilepsy 1 Genetic generalised epilepsy 1 Mesial temporal lobe epilepsy 1 Multiple congenital anomalies-hypotonia-seizures syndrome 2 (MCAHS2) 1 Neurodevelopmental disorder with epilepsy 1 PCDH19-related epilepsy 1 Primary Generalized Tonic-Clonic Seizures 1 Self-limited epilepsy with centrotemporal spikes 1 Juvenile myoclonic epilepsy 0

46 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Epilepsy

233 trials tracked for Epilepsy: 103 in phase 3 or 4 and 33 with published results. The most-cited published study has 1653 citations.

233Trials tracked
103Phase 3 & 4
0Recruiting
33With published results
Phase distribution
Phase 4 25 Phase 3 78 Phase 2 54 Phase 1 31 Other / NA 45
  1. Phase 3 Antiepileptic Efficacy Study of GWP42003-P in Children and Young Adults With Dravet Syndrome (GWPCARE1) Completed · 1,653 cited
  2. Phase 3 Efficacy and Safety of GWP42003-P for Seizures Associated With Lennox-Gastaut Syndrome in Children and Adults Completed · 973 cited
  3. Phase 4 RNS® System LTT Study Completed · 640 cited
  4. Phase 3 Childhood Absence Epilepsy Rx PK-PD-Pharmacogenetics Study Completed · 636 cited
  5. Phase 3 GWPCARE2 A Study to Investigate the Efficacy and Safety of Cannabidiol (GWP42003-P) in Children and Young Adults With Dravet Syndrome Completed · 261 cited
  6. Phase 3 Double-blind, Randomized Study Evaluating the Efficacy and Safety of Brivaracetam in Adults With Partial Onset Seizures Completed · 249 cited
Show 44 more trials
  1. Phase 3 Brivaracetam Safety and Efficacy Follow-up Study in Subjects With Epilepsy Completed · 234 cited
  2. Phase 3 Brivaracetam Efficacy and Safety Study in Subjects With Partial Onset Seizures Completed · 234 cited
  3. Phase 3 Double-blind, Randomized Study Evaluating the Efficacy and Safety of Brivaracetam in Adults With Partial Onset Seizures Completed · 228 cited
  4. Phase 3 Brivaracetam as add-on Treatment in Adolescents and Adults Suffering From Epilepsy Completed · 160 cited
  5. Phase 3 Progesterone vs Placebo Therapy for Women With Epilepsy Completed · 156 cited
  6. Phase 3 Effect of Brivaracetam (BRV) on Nonpsychotic Behavioral Side Effects in Subjects Treated Previously With Levetiracetam (LEV) Completed · 154 cited
  7. Phase 3 An Open Label Extension Study of Cannabidiol (GWP42003-P) in Children and Adults With Dravet or Lennox-Gastaut Syndromes Completed · 107 cited
  8. Phase 3 A Study to Investigate the Efficacy and Safety of Cannabidiol (GWP42003-P; CBD) as Adjunctive Treatment for Seizures Associated With Lennox-Gastaut Syndrome in Children and Adults Completed · 82 cited
  9. Phase 3 Study to Investigate Lacosamide as Add-on Therapy in Subjects ≥4 Years to <17 Years of Age With Partial Onset Seizures Completed · 62 cited
  10. Phase 3 Efficacy and Safety of Diazepam in the Management of Refractory Epilepsy in Selected Patients Who Require Intermittent Medical Intervention for Acute Repetitive Seizures. Completed · 40 cited
  11. Phase 3 This Trial, Evaluating the Long-term Safety and Tolerability of Brivaracetam Will Provide Subjects Suffering From Epilepsy, Who May Have Benefited From Brivaracetam as Adjunctive Treatment, the Opportunity to Receive Open Label Brivaracetam Treatment Completed · 34 cited
  12. Phase 4 Methylphenidate Treatment of Attention Deficits in Epilepsy Completed · 30 cited
  13. Phase 3 Study to Evaluate the Safety, Tolerability, and Efficacy of Long-term Adjunctive Therapy With Lacosamide in Adults With Partial-onset Seizures Completed · 25 cited
  14. Phase 3 A Clinical Study to Investigate the Long-term Use of Lacosamide as Monotherapy in Subjects Who Completed Study SP0994 Completed · 25 cited
  15. Phase 3 Open-label Long-term Study of Adjunctive Brivaracetam in Pediatric Subjects With Epilepsy Completed · 24 cited
  16. Phase 3 Evaluation of Long-term Safety, and Efficacy of Brivaracetam (BRV) Used as Adjunctive Treatment in Subjects With Epilepsy Completed · 24 cited
  17. Phase 3 An Open-label, Multinational, Multicenter, Follow-up Study to Evaluate the Long-term Safety and Efficacy of Brivaracetam Completed · 24 cited
  18. Phase 3 Follow-up Trial to Evaluate Long-term Safety and Efficacy of Brivaracetam in Subjects Suffering From Epilepsy Completed · 24 cited
  19. Phase 3 Safety and Tolerability of Intravenous Brivaracetam (Infusion or Bolus) as Adjunctive Antiepileptic Therapy Completed · 22 cited
  20. Phase 3 Evaluating Long Term Safety of Lacosamide (LCM) to Carbamazepine Controlled-release (CBZ-CR); Initial Monotherapy in Epilepsy Subjects 16 Years and Older Completed · 17 cited
  21. Phase 3 Study to Evaluate the Safety and Efficacy of USL261 in Patients With Increased Bouts of Seizure Activity in the EMU Completed · 16 cited
  22. Phase 3 Add on Lacosamide Versus High Dose Monotherapy Completed · 12 cited
  23. Phase 3 Study to Assess the Safety and Tolerability of Intravenous Carbamazepine in Adults With Epilepsy Completed · 9 cited
  24. Phase 3 Study to Investigate Safety and Tolerability of Intravenous Lacosamide in Children. Completed · 7 cited
  25. Phase 3 Safety and Efficacy of Lacosamide as Additional Therapy in Patients Suffering From Epileptic Tonic-Clonic Seizures Completed · 4 cited
  26. Phase 3 A Study to Test the Safety/ Efficacy of Brivaracetam (BRV) Used as Adjunctive Treatment in Subjects >=16 Years of Age With Partial Seizures With or Without Secondary Generalization Completed
  27. Phase 3 A Study to Evaluate the Efficacy and Safety of Brivaracetam in Study Participants (>=16 to 80 Years of Age) With Epilepsy Completed
  28. Phase 4 BEEP Follow Up: Evaluation of Repeatability of Lamotrigine Pharmacokinetics in Epileptic Patients Completed
  29. Phase 4 Comparison of the Cognitive and Behavioral Effects of Eslicarbazepine Acetate and Carbamazepine in Healthy Adults Completed
  30. Phase 4 A Pilot Study of Dexmedetomidine-Propofol in Children Undergoing Magnetic Resonance Imaging Completed
  31. Phase 4 Trial Evaluating the Efficacy and Safety of Perampanel Added to Monotherapy in Participants With Partial Onset Seizures With or Without Secondary Generalization Completed
  32. Phase 4 Anxiety and Depression in Epilepsy: A Treatment Study Completed
  33. Phase 4 Lamotrigine Bioequivalence Completed
  34. Phase 4 Use of Clobazam for Epilepsy and Anxiety Completed
  35. Phase 4 Fycompa Titration Intervals and Effects on Retention Rate Completed
  36. Phase 4 Lyrica (Pregabalin) Administered as an Add-on Therapy for Partial Seizures (LEADER). Completed
  37. Phase 4 First Add-on vs. Mono-therapy Study of Topiramate in Neuro-Surgical Patients Completed
  38. Phase 4 A Pilot Study to Evaluate Efficacy and Safety of Clevidipine in Neurosurgical Patients Completed
  39. Phase 4 A Study to Assess Tolerability and Efficacy of Topiramate Monotherapy in Recently Diagnosed Patients With Epilepsy Completed
  40. Phase 4 Comparative Study of Zonisamide and Carbamazepine as an Initial Monotherapy: Efficacy and Safety Evaluation Completed
  41. Phase 4 Valproate Dose Reduction and Its Clinical Evaluation by Introducing Lamotrigine in Japanese Women With Epilepsy - Single Arm, Multicenter, and Open-label Study Completed
  42. Phase 4 The Efficacy and Safety of Low Dose Combination of LTG and VPA Compared to CBZ Monotherapy Completed
  43. Phase 4 Low and High Dose Zonisamide in Children as Monotherapy Completed
  44. Phase 4 Levetiracetam Versus Oxcarbazepine as Monotherapy to Evaluate Efficacy and Safety in Subjects With Newly or Recently Diagnosed Partial Epilepsy Completed

Showing the 50 most-cited and recently-updated of 233 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
ACTH and vigabatrin achieved full seizure control in a patient with Ververi-Brady syndrome
Neurology Sys. Review
ACTH and vigabatrin achieved full seizure control in a patient with Ververi-Brady syndrome ACTH and Vigabatrin Show Promise for Rare Epilepsy Syndrome
This case report describes a 5-month-old male infant with Ververi-Brady syndrome and infantile epileptic spasms syndrome. The patient achiev…
A new gene variant linked to Ververi-Brady syndrome showed positive results when treated with a combination of ACTH and vigabatrin.
Frontiers Jun 15, 2026
Evaluating the Impact of Digital Health Interventions on Chronic Disease Self-Care Outcomes
Physical Medicine & Rehab Meta-analysis
Evaluating the Impact of Digital Health Interventions on Chronic Disease Self-Care Outcomes Digital health tools show mixed results for managing chronic diseases
Digital tools show promise for heart failure monitoring but lack consistent evidence for improving medication adherence or general diabetes …
New data shows that while digital tools like apps can help heart failure patients monitor their health, they may not improve medication habi…
Jun 13, 2026
First case report links zonisamide to homicidal ideation in epilepsy patient
Psychiatry Sys. Review
First case report links zonisamide to homicidal ideation in epilepsy patient First case report links zonisamide to homicidal thoughts in an epilepsy patient
A case report and literature review describes a patient with epilepsy who developed homicidal ideation during zonisamide uptitration. Sympto…
A patient developed homicidal thoughts after taking zonisamide. This rare case highlights a serious psychiatric side effect of the drug that…
Frontiers Jun 1, 2026
MRI-guided laser interstitial thermal therapy shows variable seizure freedom in drug-resistant epilepsy
Orthopedics & Sports Medicine Meta-analysis
MRI-guided laser interstitial thermal therapy shows variable seizure freedom in drug-resistant epilepsy MRI laser therapy for drug-resistant epilepsy shows wide seizure freedom rates
A systematic review of systematic reviews evaluated MRI-guided laser interstitial thermal therapy for patients with drug-resistant epilepsy.…
A review of 16 studies finds MRI-guided laser therapy can free some patients from seizures, but the success rate varies widely and safety ri…
Frontiers May 29, 2026
Systematic review and meta-analysis of levetiracetam efficacy in pediatric epilepsy patients
Pediatrics Meta-analysis
Systematic review and meta-analysis of levetiracetam efficacy in pediatric epilepsy patients Levetiracetam shows seizure benefits over placebo in children with epilepsy
This systematic review and meta-analysis evaluated levetiracetam (LEV) in patients 16 years or younger with epilepsy. The analysis included …
A large analysis found levetiracetam improved seizure freedom and responder rates compared to placebo in children, though it did not consist…
May 28, 2026
Review synthesizes neuroprotective potential of TCM metabolites using zebrafish models for neurological conditions
Drug Pipeline Sys. Review
Review synthesizes neuroprotective potential of TCM metabolites using zebrafish models for neurological conditions Traditional Chinese medicine metabolites protect brain cells from damage
This review examines the utility of Traditional Chinese medicine (TCM) metabolites for neurological conditions including Alzheimer's disease…
A review shows Traditional Chinese medicine metabolites protect brain cells through anti-inflammatory and anti-oxidative stress actions, off…
Frontiers May 25, 2026
Exosome therapy reduces seizures and inflammation in preclinical epilepsy models: a meta-analysis
Neurology Meta-analysis
Exosome therapy reduces seizures and inflammation in preclinical epilepsy models: a meta-analysis Tiny Particles From Stem Cells Could Quiet Epilepsy Seizures
This systematic review and meta-analysis of 8 preclinical studies found that exosome therapy reduced seizure duration, frequency, and latenc…
What if a simple infusion of microscopic particles could calm the brain storms of epilepsy without the side effects of today's drugs.
Frontiers May 15, 2026
Narrative review links NRXN1 genetic variations to schizophrenia, autism, and other neuropsychiatric disorders
Neurology Sys. Review
Narrative review links NRXN1 genetic variations to schizophrenia, autism, and other neuropsychiatric disorders New research explains how one gene causes many brain disorders
This narrative review examines the association between NRXN1 genetic variations and a spectrum of neuropsychiatric disorders including schiz…
A single gene variation may explain why schizophrenia and autism often appear together, offering new hope for understanding these complex br…
Frontiers May 13, 2026
Review of animal models links temporal lobe epilepsy to sleep and circadian disruption
Neurology Sys. Review
Review of animal models links temporal lobe epilepsy to sleep and circadian disruption Animal studies show epilepsy and sleep problems affect each other in many ways
This narrative review synthesizes findings from rodent models of temporal lobe epilepsy. It reports consistent sleep fragmentation and disru…
Research using animal models reveals that seizures and sleep issues often happen together. These studies help doctors understand how brain d…
Frontiers May 8, 2026
Modified prednisone regimen shows short-term ineffectiveness in infantile epileptic spasms syndrome based on retrospective cohort data
Allergy & Immunology Cohort
Modified prednisone regimen shows short-term ineffectiveness in infantile epileptic spasms syndrome based on retrospective cohort data Blood marker may predict prednisone response in infantile spasms
This retrospective cohort study evaluated 66 IESS patients and 53 age-matched healthy controls.
A blood protein called HMGB1 may help doctors quickly tell if prednisone will work for infantile spasms.
Frontiers May 1, 2026
Higher levels of dissociative symptoms observed in individuals with functional neurological disorder
Psychiatry Case-Control
Higher levels of dissociative symptoms observed in individuals with functional neurological disorder People with FND experience higher levels of dissociation
This pilot study used ecological momentary assessment to compare symptoms between individuals with functional neurological disorder and heal…
New tracking data shows that individuals living with functional neurological disorder report significantly more dissociative symptoms during…
Frontiers Apr 30, 2026
Observational study finds higher hostility bias in genetic generalised epilepsy
Neurology
Observational study finds higher hostility bias in genetic generalised epilepsy People with genetic generalised epilepsy show higher hostility bias than healthy controls
This observational study compared attributional bias in 96 participants with genetic generalised epilepsy, temporal lobe epilepsy, and healt…
A new study found that people with genetic generalised epilepsy often blame others more than healthy people do, a sign of social difficulty.
medRxiv Apr 30, 2026

Questions about Epilepsy

Does prior brain surgery change how vagus nerve stimulation works?

Prior brain surgery for epilepsy does not appear to change how well vagus nerve stimulation works for drug-resistant epilepsy, based on real-world data.

Full answer →
Can deep learning detect focal cortical dysplasia in pediatric drug-resistant epilepsy?

Yes, deep learning models like MELD Graph and 3D-nnUNet can detect focal cortical dysplasia in pediatric drug-resistant epilepsy, with moderate accuracy and fewer false positives in MRI-negative cases.

Full answer →
How does vagus nerve stimulation work for drug-resistant epilepsy?

Vagus nerve stimulation (VNS) works by sending electrical impulses to the vagus nerve, which then modulates brain networks and neurotransmitters to reduce seizure frequency in drug-resistant epilepsy.

Full answer →
Can heart rhythm tests predict seizures in children with epilepsy?

Heart rhythm tests like ECG can detect changes before some seizures, but they are not yet reliable enough to predict seizures in children with epilepsy.

Full answer →

All Epilepsy Articles