N/A N=50

Study of the Relationship Between Glycogen Storage Disease Type Ia and Inflammatory Bowel Disease

Inflammatory Bowel Disease · Glycogen Storage Disease Type Ia

Bottom Line

View on ClinicalTrials.gov: NCT01854242 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Dec 2014

Primary outcome: Primary: Serologic, Genetic and Inflammatory Markers Consistent With Inflammatory Bowel Disease — 11 participants testing positive

Study Design & Population

Study type: Observational
Phase: N/A
Interventions: Glycogen Storage Disease type Ia patients (Other)
Age: Pediatric, Adult, Older Adult
Sex: All
Sponsor: University of Florida
Primary completion: Oct 2014

Outcome Measures

Outcome	Result	p-value
PRIMARY Serologic, Genetic and Inflammatory Markers Consistent With Inflammatory Bowel Disease	11	—

Summary

The purpose of this research study is to understand the relationship between inflammatory bowel disease (IBD) and Glycogen storage disease (GSD)type Ia. GSD type Ib has been established to have an association with IBD with clinical and histologic features that mirror those of Crohn disease. Development of the disease seems to be related to the defect of neutrophil function in individuals with GSD type Ib and subsequent colonic inflammation. In the last decade, it has become a standard for patients with GSD type Ib and gastrointestinal symptoms to be evaluated for IBD. Patients with GSD type Ia were not recognized to have similar gastrointestinal symptoms until recently. The prevalence of IBD is greater in patients with GSD type Ia versus the general population.

Eligibility Criteria

Inclusion Criteria

Anyone with Glycogen Storage Disease type Ia

Exclusion Criteria

Anyone where the amount of blood needed to complete the Prometheus test exceeds 3ml/kg.

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01854242). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.