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Home › Conditions › Inflammatory Bowel Disease

Inflammatory Bowel Disease

Subtypes of Inflammatory Bowel Disease

Ulcerative Colitis 30 Crohn's Disease 26

66 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Inflammatory Bowel Disease

68 trials tracked for Inflammatory Bowel Disease: 19 in phase 3 or 4 and 12 with published results. The most-cited published study has 131 citations.

68Trials tracked
19Phase 3 & 4
0Recruiting
12With published results
Phase distribution
Phase 4 9 Phase 3 10 Phase 2 10 Phase 1 6 Other / NA 33
  1. Phase 3 Safety and Efficacy Study of Oral Ferric Iron To Treat Iron Deficiency Anaemia in Quiescent Crohn's Disease (AEGIS-2) Completed · 131 cited
  2. Phase 3 Safety and Efficacy Study of Oral Ferric Iron To Treat Iron Deficiency Anaemia in Quiescent Ulcerative Colitis (AEGIS-1) Completed · 131 cited
  3. Phase 3 Telemedicine in Patients With Inflammatory Bowel Disease (TELE-IBD) Completed · 61 cited
  4. Phase 3 A Study to Evaluate the Safety and Efficacy of Ustekinumab in Patients With Moderately to Severely Active Crohn's Disease Who Have Failed or Are Intolerant to Tumor Necrosis Factor (TNF) Antagonist Therapy (UNITI-1) Completed · 40 cited
  5. Phase 3 A Study to Evaluate the Safety and Efficacy of Ustekinumab Induction Therapy in Patients With Moderately to Severely Active Crohn's Disease (UNITI-2) Completed · 40 cited
  6. Phase 3 A Study to Evaluate the Safety and Efficacy of Ustekinumab Maintenance Therapy in Patients With Moderately to Severely Active Crohn's Disease (IM-UNITI) Completed · 40 cited
Show 44 more trials
  1. Phase 4 Randomized, Placebo-controlled Trial of Lubiprostone as a Preparation for Capsule Endoscopy Completed · 38 cited
  2. Phase 3 A Study to Evaluate the Safety and Efficacy of Ustekinumab Induction and Maintenance Therapy in Participants With Moderately to Severely Active Ulcerative Colitis Completed · 38 cited
  3. Phase 4 Intraoperative TAP Block With Bupivacaine/Dexamethasone Against Liposomal Bupivacaine (Exparel®) Completed · 25 cited
  4. Phase 4 Chronotherapy in Inflammatory Bowel Disease Completed · 11 cited
  5. Phase 4 Immunogenicity of Herpes Zoster Subunit Vaccine in Inflammatory Bowel Disease Patients Treated With Vedolizumab Completed · 2 cited
  6. Phase 4 Safety of Reduced Infliximab Infusion Time Completed
  7. Phase 4 Treating Disrupted Sleep in Individuals With Inflammatory Bowel Disease Completed
  8. Phase 4 Immune Response to the Human Papillomavirus Vaccine in Young Women With Inflammatory Bowel Disease Completed
  9. Phase 4 NITI CAR27 (ColonRing) Compression Anastomosis in Colorectal Surgery Completed
  10. Phase 4 Gene Regulation by Thiazolidinediones Completed
  11. Phase 3 Open-Label, Long-term Balsalziade Disodium Tablet Ulcerative Colitis Study Completed
  12. Phase 3 Safety and Efficacy Study of Oral Ferric Maltol Compared to Intravenous Iron To Treat Iron Deficiency Anaemia in IBD Completed
  13. Phase 3 The Home Telemanagement (UC HAT) Trial for Patients With Ulcerative Colitis Completed
  14. Phase 2 ICON-2: FMT and Bezlotoxumab Compared to FMT and Placebo for Patients With IBD and CDI Completed
  15. Phase 2 Fecal Microbiota Transplant (FMT) in Pediatric Active Ulcerative Colitis and Pediatric Active Crohn's Colitis Completed
  16. Phase 2 A Phase 2a Open-Label Study to Evaluate the Efficacy and Safety of MORF-057 in Adults With UC Completed
  17. Phase 2 The ICON Study: Outcomes After FMT for Patients With IBD and CDI Completed
  18. Phase 2 A Trial of Rosiglitazone for Ulcerative Colitis Completed
  19. Phase 2 Telemedicine To Provide Inflammatory Bowel Disease Outpatient Care Completed
  20. Phase 2 Study of a Monoclonal Antibody KHK4083 in Moderate Ulcerative Colitis Completed
  21. Phase 2 Dietary Treatment of Crohn's Disease Completed
  22. Phase 2 Sirolimus for Autoimmune Disease of Blood Cells Completed
  23. Phase 2 Examining the Efficacy of Fecal Microbiota Transplantation (FMT) and Dietary Fiber in Patients With Ulcerative Colitis Completed
  24. Phase 1 Safety and Tolerability Of Allogeneic Mesenchymal Stromal Cells in Pediatric Inflammatory Bowel Disease Completed
  25. Phase 1 Evaluation of the Pharmacokinetics, Safety and Tolerability of Single Dose of PF-06480605 in Chinese Healthy Participants Completed
  26. Phase 1 Vitamin D Supplementation in Crohn's Patients Completed
  27. Phase 1 Immune Response to Systemic and Mucosal Antigenic Challenge in the Presence of Vedolizumab Completed
  28. Phase 1 Phase 1 Study for IPG11406 in Health Volunteer Completed
  29. Phase 1 Bacteriotherapy in Pediatric Inflammatory Bowel Disease Completed
  30. N/A Assessment of the Social Cost of Crohn's Disease: Economic and Quality of Life Aspects (Study P04560) Completed
  31. N/A Biomarkers of Anti-TNF Treatment in Inflammatory Bowel Disease (IBD) Completed
  32. N/A Perianal Fistula (PAF) Validation and Burden of Illness Study Completed
  33. N/A Feraccru® Real World Effectiveness Study in Hospital Practice ( FRESH ) Completed
  34. N/A Comparison of Capso Vision SV-1 to PillCam SB2 in the Evaluation of Subjects With Suspected Small Bowel Disease Completed
  35. N/A A Study to Evaluate Disease Control, Treatment Patterns, Burden of Disease and Quality of Life in Participants With Moderate to Severe Inflammatory Bowel Disease (IBD) Completed
  36. N/A A Study of Moderate to Severe Inflammatory Bowel Disease, Including Ulcerative Colitis (UC) and Crohn's Disease (CD) Completed
  37. N/A Study of Relationship Between Vedolizumab Therapeutic Drug Monitoring, Biomarkers of Inflammation and Clinical Outcomes Completed
  38. N/A Patient Attitudes and Preferences for Outcomes of Inflammatory Bowel Disease Therapeutics Completed
  39. N/A Digital Behavioral Interventions in Inflammatory Bowel Disease Completed
  40. N/A Autoimmune Protocol Diet and Inflammatory Bowel Disease Completed
  41. N/A The Risk of Venous Thromboembolism in Systemic Inflammatory Disorders: a United Kingdom (UK) Matched Cohort Study Completed
  42. N/A Stress in Inflammatory Bowel Disease Completed
  43. N/A Specialty Medical Homes to Improve Outcomes for Patients With IBD and Behavioral Health Conditions Completed
  44. N/A A Comparison of Ultrasound Guided Transversus Abdominis Plane Nerve Block Techniques Completed

Showing the 50 most-cited and recently-updated of 68 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Acute cellular senescence facilitates tissue repair while chronic accumulation drives intestinal fibrosis in Crohn's disease
Hematology Sys. Review
Acute cellular senescence facilitates tissue repair while chronic accumulation drives intestinal fibrosis in Crohn's disease Chronic cell aging may drive scarring in Crohn's disease
This systematic review examines the role of cellular senescence in intestinal fibrosis within Crohn's disease. The authors conclude that acu…
New research reveals how the timing of cellular aging determines whether your body heals properly or develops harmful scar tissue.
Frontiers Jun 13, 2026
Epigallocatechin-3-gallate shows positive therapeutic effects on various digestive system diseases in animal models
Oncology Meta-analysis
Epigallocatechin-3-gallate shows positive therapeutic effects on various digestive system diseases in animal models Green tea compound shows potential for several digestive diseases
This meta-analysis of 63 preclinical studies involving 738 animals indicates that Epigallocatechin-3-gallate (EGCG) has a positive therapeut…
A review of animal studies suggests a green tea compound could help treat various cancers and digestive conditions.
Frontiers Jun 11, 2026
Mucus-barrier regulatory programs in Crohn's disease and ulcerative colitis involve ER stress and microbial sensing
Allergy & Immunology Meta-analysis
Mucus-barrier regulatory programs in Crohn's disease and ulcerative colitis involve ER stress and microbial sensing New findings show how mucus barriers fail in Crohn's and Ulcerative Colitis
This meta-analysis of transcriptomic datasets and an Agr2-/- mouse model identifies consensus mucus-barrier regulatory programs in active IB…
Researchers found that specific genes control the protective mucus layer in the gut. These same pathways are disrupted in people with IBD.
Frontiers Jun 9, 2026
CAR technology for autoimmune disorders, infectious diseases, fibrotic lesions, inflammatory bowel disease, and type 1 diabetes is reviewed
Allergy & Immunology Sys. Review
CAR technology for autoimmune disorders, infectious diseases, fibrotic lesions, inflammatory bowel disease, and type 1 diabetes is reviewed Chimeric antigen receptor technology may help treat autoimmune disorders and other conditions
This narrative review discusses the application of chimeric antigen receptor (CAR) technology across autoimmune disorders, infectious diseas…
A narrative review suggests chimeric antigen receptor technology could be useful for treating autoimmune disorders, infectious diseases, and…
Frontiers Jun 6, 2026
Stress-induced IL-6 upregulation impairs skeletal growth and bone health in children with inflammatory diseases
Diabetes & Endocrinology Sys. Review
Stress-induced IL-6 upregulation impairs skeletal growth and bone health in children with inflammatory diseases Stress hormones may harm bone growth in children with inflammatory conditions
This narrative review synthesizes evidence from animal models and pediatric inflammatory disorders showing that stress-induced IL-6 upregula…
A review suggests stress-induced IL-6 upregulation impairs skeletal growth and bone health in kids with inflammatory disorders, highlighting…
Frontiers Jun 6, 2026
IBD-related neuroimaging shows brain alterations in emotional networks with distinguishable phenotypes for Crohn's and ulcerative colitis
Neurology Sys. Review
IBD-related neuroimaging shows brain alterations in emotional networks with distinguishable phenotypes for Crohn's and ulcerative colitis Brain scans show different emotional patterns in Crohn's and ulcerative colitis
This bibliometric analysis and systematic scoping review examines 175 articles on IBD-related neuroimaging literature from Web of Science an…
A review of 175 articles found that brain activity in Crohn's and ulcerative colitis affects emotion centers differently. This suggests dist…
Frontiers Jun 4, 2026
Gut microbiota alterations linked to anxiety and depression in inflammatory bowel disease patients
Gastroenterology Meta-analysis
Gut microbiota alterations linked to anxiety and depression in inflammatory bowel disease patients Gut bacteria patterns linked to anxiety and depression in inflammatory bowel disease patients
This systematic review of 1,040 patients with inflammatory bowel disease found associations between gut microbiota characteristics and anxie…
A review of 1,040 patients found gut bacteria patterns linked to anxiety and depression in inflammatory bowel disease.
Frontiers Jun 2, 2026
Darvadstrocel shows 48.8% combined remission in Crohn's perianal fistulas, not superior to placebo
Drug Pipeline RCT
Darvadstrocel shows 48.8% combined remission in Crohn's perianal fistulas, not superior to placebo Darvadstrocel showed no better results than placebo for Crohn's disease fistulas
This Phase 3 randomized trial in adults with Crohn's disease and complex perianal fistulas found that darvadstrocel did not achieve a statis…
A major trial found darvadstrocel did not improve closure of Crohn's fistulas compared to placebo, showing no significant benefit for patien…
Gastroenterol Jun 1, 2026
Mediterranean diet shows no significant advantage over control diets for inducing remission in inflammatory bowel disease patients
Nutrition & Obesity Medicine Meta-analysis
Mediterranean diet shows no significant advantage over control diets for inducing remission in inflammatory bowel disease patients Mediterranean diet helps some patients with inflammatory bowel disease reach remission better than control diets
This systematic review and meta-analysis evaluated the Mediterranean diet versus control diets in patients with inflammatory bowel disease. …
A review of studies found that a Mediterranean diet helped about 62% of patients reach remission. This approach worked well for both Crohn's…
Jun 1, 2026
Guideline secondary analysis shows non-significant trend for higher enteral nutrition use in pediatric Crohn's disease registry groups
Pediatrics Guideline
Guideline secondary analysis shows non-significant trend for higher enteral nutrition use in pediatric Crohn's disease registry groups Registry tool shows mixed results for pediatric Crohn's nutrition
This guideline secondary analysis of a cluster-randomized trial examines enteral nutrition patterns in 110 children with Crohn's disease. Th…
A new registry tool did not significantly boost enteral nutrition use in children with Crohn's, but it may lower steroid use in the first 90…
Frontiers May 26, 2026
Narrative review explores microbiome-targeting therapies for inflammatory bowel disease patients
Gastroenterology Sys. Review
Narrative review explores microbiome-targeting therapies for inflammatory bowel disease patients New microbial therapies for inflammatory bowel disease show promise
This narrative review examines the potential of targeting the microbial-metabolic axis for patients with inflammatory bowel disease. The aut…
A review explores how targeting the microbial-metabolic axis might help patients with inflammatory bowel disease using treatments like fecal…
Frontiers May 22, 2026
Narrative Review Explores Alistipes Genus Role in Inflammatory and Cancers
Infectious Disease Sys. Review
Narrative Review Explores Alistipes Genus Role in Inflammatory and Cancers Alistipes bacteria may hold new hope for inflammatory bowel diseases and digestive cancer
This narrative review synthesizes evidence on the Alistipes genus and its metabolites in inflammatory bowel diseases, digestive, lung, prost…
A review suggests Alistipes bacteria and their chemicals might help treat inflammatory bowel diseases and several cancers, offering fresh di…
Frontiers May 21, 2026

Questions about Inflammatory Bowel Disease

How does oral microbial diversity in Crohn's disease compare to people without the condition?

People with Crohn's disease have significantly lower oral microbial diversity compared to healthy individuals, with specific bacterial shifts and reduced butyrate metabolism.

Full answer →
Can enteral nutrition therapy help achieve remission for Chinese patients with inflammatory bowel disease?

Yes, enteral nutrition therapy can help achieve remission in Chinese IBD patients, with a 60% clinical remission rate over 6 weeks, especially in Crohn's disease.

Full answer →
What is the link between gut microbial metabolites and colorectal cancer risk in inflammatory bowel disease?

Gut microbial metabolites like short-chain fatty acids protect against colorectal cancer in IBD, while secondary bile acids, TMAO, and hydrogen sulfide promote it.

Full answer →
How does childhood antibiotic use affect the risk of developing inflammatory bowel disease?

Childhood antibiotic use is linked to a higher risk of developing inflammatory bowel disease, with a meta-analysis showing a 42% increased risk overall.

Full answer →

All Inflammatory Bowel Disease Articles