N/A N=348 Treatment

Emergency Department (ED) Drug Interaction in Emergency Department Patients

Drug Interactions

Bottom Line

View on ClinicalTrials.gov: NCT01859715 ↗

Enrolled (actual)

348

Serious AEs

0.0%

Results posted

May 2016

Primary outcome: Primary: Difference in Clinically Significant Visual Analogue Scale for Pain and Nausea Change Between CYP2D6 Users and Non-users — 7.4; 10.9; -14.0 millimeters

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Oxycodone (Drug); Hydrocodone (Drug); Ondansetron (Drug)
Age: Adult, Older Adult · 18+ yrs
Sex: All
Sponsor: University of Colorado, Denver
Primary completion: Jan 2013

Outcome Measures

Outcome	Result	p-value
PRIMARY Difference in Clinically Significant Visual Analogue Scale for Pain and Nausea Change Between CYP2D6 Users and Non-users	7.4; 10.9; -14.0	—
SECONDARY Adverse Drug Events	0; 0; 0	—

Summary

This study examines how hepatic cytochrome CYP2D6 drug interactions affects the efficacy of oxycodone, hydrocodone, and ondansetron in Emergency Department (ED) patients.

Eligibility Criteria

Inclusion Criteria

self-reported pain or nausea identified by the initial nursing assessment

Exclusion Criteria

unable to speak English,
< 18 y.o.,
previously diagnosed with chronic pain or cyclic vomiting

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01859715). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.