Phase 1 N=11 Prescription Medication Interactions
Opioid Use · Sedative Use
Primary: Change in Subject-Rated Outcome: Visual Analog Scale (VAS) Drug Liking — 7.40; 39.00; 40.80; 24.50 Score on a scale — p=<0.0001
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=28 Drug-Drug Interaction of Cardizem LA (Diltiazem Hydrochloride) on Pitavastatin
Healthy
Primary: NK-104 AUC — 208.92 ng * h/mL
Phase 1 N=22 Interactions Between Cannabinoids and Cytochrome P450-Metabolized Drugs
Drug-Interactions
Primary: Losartan Area Under the Curve (AUC) in Plasma — 164; 185; 289 h*ng/mL
N/A N=348 Emergency Department (ED) Drug Interaction in Emergency Department Patients
Drug Interactions
Primary: Difference in Clinically Significant Visual Analogue Scale for Pain and Nausea Change Between CYP2D6 Users and Non-users — 7.4; 10.9; -14.0 millimeters
Phase 1 N=30 Transporter Cocktail Mutual Interaction
Healthy
Primary: Area Under the Curve of Digoxin From 0 to Last Quantifiable Data Point (AUC 0-tz) — 11.549; 11.981 nanomole hour per liter (nmol·h/L)
Phase 4 N=10 Drug-Drug Interaction Between Rifampin and Fluvastatin
Drug-drug Interaction
Primary: AUC — 242; 642; 124; 371 ng/mL·h
Phase 1 N=11 Doravirine, Rifapentine and Isoniazid Interaction
Latent Tuberculosis · Human Immunodeficiency Virus · Rifamycins Causing Adverse Effects in Therapeutic Use
Primary: Doravirine Maximum Concentration (Cmax) — 1.7; 1.3 ug/mL
Early Phase 1 N=8 Assessing the Pharmacokinetics and Drug Interaction Liability of Kratom, an Opioid-like Natural Product
Interaction Drug Food
Primary: Midazolam Area Under the Concentration vs. Time Curve (AUC) — 58.3; 80.8 nM * hr
Phase 1 N=24 Drug-Drug Interaction Between Colchicine and Verapamil ER
Pharmacokinetics
Primary: Maximum Plasma Concentration (Cmax) — 2,968.42; 3,850.63 pg/mL
Phase 1 N=24 Drug-Drug Interaction Between Colchicine and Ritonavir
Pharmacokinetics
Primary: Maximum Plasma Concentration (Cmax) — 1,869.50; 4,993.06 pg/mL
Phase 1 N=16 Drug Drug Interaction of BI 201335 and Tenofovir
HIV Infections
Primary: Steady-state Pharmacokinetics of AUC0-24 of Tenofovir on Day 7 and on Day 15 — 2700; 3290 ng*h/mL
N/A N=10 The Effects of Multiple Dose Fluoxetine and Metabolites on CYP1A2, CYP2C19, CYP2D6 and CYP3A4 Activity
Drug-Drug Interaction · Healthy Volunteers
Primary: Lovastatin AUC in the Presence of Fluoxetine — 170; 180 nmol*hr/L — p=>0.05
Phase 1 N=29 Sulforaphane as an Antagonist to Human PXR-mediated Drug-drug Interactions
Adverse Drug Interactions
Primary: Midazolam Clearance (Pharmacokinetic Measure of Cytochrome P450 3A4 Activity) — 604; 552; 541; 156 ng*min/ml
Phase 1 N=16 Drug-drug Interaction of BI 201335 and Microgynon
Hepatitis C, Chronic
Primary: AUCt,ss of Ethinylestradiol — 1010; 1450 pg*h/mL
Phase 1 N=24 Drug-Drug Interaction Study Between Colchicine and Diltiazem ER
Healthy; Adult; Volunteer; Colchicine; Pharmacokinetics; Diltiazem; Cytochrome p450 3A4; P-glycoprotein
Primary: Maximum Plasma Concentration (Cmax) — 2,172.32; 2,802.90 pg/mL
N/A N=12 Pharmacokinetic Interactions Between Buprenorphine and Tipranavir/Ritonavir
HIV Infections
Primary: Area Under the Curve of BUP/NLX With TPV/r (h*ng/mL) — 43.7 h*ng/mL
Phase 1 N=30 Metronidazole Drug Interaction Study With MMX® Mesalazine/Mesalamine
Healthy
Primary: Area Under the Plasma Concentration Curve (AUC) at Steady State for Metronidazole — 217686; 215809 ng*h/ml
Phase 1 N=24 Drug - Drug Interaction Study of Quinine Sulfate and Ciprofloxacin
Healthy
Primary: Maximum Plasma Concentration(Cmax) — 4,240.65; 4,521.20 ng/mL
Phase 1 N=24 Drug-Drug Interaction Study Between Colchicine and Ketoconazole
Pharmacokinetics
Primary: Maximum Plasma Concentration (Cmax) — 2,779.08; 5,266.92 pg/mL
Phase 1 N=24 Drug-Drug Interaction Study of Colchicine and Clarithromycin
Pharmacokinetics
Primary: Maximum Plasma Concentration (Cmax) — 2.84; 8.44 ng/mL
Phase 4 N=28 Drug-Drug Interaction of Darunavir/Ritonavir on Pitavastatin
Healthy
Primary: NK-104 AUC — 192.00 ng * h/mL
Phase 1 N=27 Drug-Drug Interaction Study: ASP2151 and Midazolam
Healthy
Primary: Peak Plasma Concentration (Cmax) of Midazolam — 34.5; 23.4; 38.8; 36.8 ng/mL
Phase 1 N=13 Interaction of BI 425809 With Midazolam, Warfarin, Omeprazole and Digoxin
Healthy
Primary: Area Under the Concentration-time Curve of Midazolam in Plasma Over the Time Interval From 0 to the Last Quantifiable Data Point (AUC0-tz) — 19.0; 23.5; 16.0 nanogram…
Phase 1 N=24 Drug-Drug Interaction Study of Qualaquin and Midazolam
Healthy
Primary: Maximum Serum Concentration (Cmax) — 12.0435; 4.6907; 4432.4089; 12.5585 ng/ml
Phase 4 N=22 ADASUVE-Lorazepam Drug-Drug Interaction
Healthy Volunteers
Primary: Maximum Level of Sedation for Lorazepam 1 mg IM + ADASUVE 10 mg — 12.3 units on a scale
N/A N=19 Moringa Oleifera- Antiretroviral Pharmacokinetic Drug Interaction
HIV
Primary: AUC — 94.17; 34.67; 100.44; 32.58 h*microgram/mL
Phase 1 N=13 Effect of Copanlisib on Metformin Pharmacokinetics and Pharmacodynamics
Healthy Volunteers
Primary: Maximum Drug Concentration of Metformin in Plasma After Single Dose Administration (Cmax) — 1550; 1460 microgram per liter (mcg/L)
Phase 1 N=16 DDI Between BI Empagliflozin (10773) and Verapamil
Healthy
Primary: Area Under the Curve 0 to Infinity (AUC0-∞) — 5190; 5340 nmol*h/L
N/A N=26 Potential for Drug-drug Interactions Between Boceprevir and Etravirine in HIV/Hepatitis C Virus Negative Volunteers
Hepatitis C · HIV
Primary: Boceprevir AUC Pharmacokinetics — 4601 ng*hr/mL
Phase 1 N=18 Drug-drug Interaction of Empagliflozin (BI 10773) and Microgynon
Healthy
Primary: Ethinylestradiol: Area Under the Curve at Steady State Over the Uniform Dosing Interval τ (AUCτ,ss) — 907; 932 pg*h/mL