Phase 4 Completed N=52 Randomized Quadruple-blind Supportive Care

Dexamethasone for Post Cesarean Delivery Analgesia

Postoperative Pain

Source: ClinicalTrials.gov NCT01868633 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Jun 2017

Primary outcomePrimary: Postoperative Analgesia — 11.8; 15 milligrams of morphine — p=0.32

◆ Published Evidence

No publication linked

No peer-reviewed publication reporting this trial's results has been linked yet. This can indicate results are unpublished — a known publication-bias signal. We re-check periodically.

Summary

The purpose of this study is to assess the effectiveness intravenous (IV) dexamethasone when used as part of a multimodal regimen to manage post cesarean delivery pain. We hypothesize that a single dose of IV dexamethasone administered, as part of a multimodal analgesia after spinal anesthesia will significantly reduce post cesarean delivery opioid consumption and pain

Outcome Measures

Outcome	Result	p-value
PRIMARY Postoperative Analgesia	11.8; 15	0.32
SECONDARY Postoperative Pain at Rest and With Movement 24 Hours After Cesarean Delivery	1; 1; 4; 4.5; 1; 2	—
SECONDARY Quality of Recovery	180; 177	—
SECONDARY Incidence and Severity of Nausea and Pruritus	6; 2.5; 5; 3; 0; 0	—

Eligibility Criteria

Inclusion Criteria

English Speaking
Non-laboring women
Scheduled Elective Cesarean section under spinal anesthesia
American Society of Anesthesiologists I-II physical status

Exclusion Criteria

Contraindications to spinal anesthesia
allergy to study medication
patients with allergy to morphine
patients with uncontrolled hypertension
history of peptic ulcer disease
liver cirrhosis
diabetes mellitus
glaucoma
known IV drug abusers
patients with chronic pain or on long term opioids
patients administered steroids in the past week
women with fetuses having known congenital abnormalities
psychiatric illness such that they are unable to comprehend or participate in study questions
patients on antiviral medications or live virus vaccines would also be excluded.

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01868633). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.