Phase 4 N=144 Randomized Double-blind Health Services Research

Comparison of Emergence Agitation Between Sevoflurane and Desflurane Anesthesia After Orthognathic Surgery

Emergence Agitation

Bottom Line

View on ClinicalTrials.gov: NCT01878656 ↗

Enrolled (actual)

144

Serious AEs

0.0%

Results posted

May 2014

Primary outcome: Primary: The Incidence of Emergence Agitation Using Four-point Categorical Scale — 51; 17 participants

Study Design & Population

Study type: Interventional
Phase: Phase 4
Interventions: Sevoflurane (Drug); Desflurane (Drug)
Age: Adult · 18+ yrs
Sex: All
Sponsor: Chung-Ang University Hosptial, Chung-Ang University College of Medicine
Primary completion: Feb 2014

Outcome Measures

Outcome	Result	p-value
PRIMARY The Incidence of Emergence Agitation Using Four-point Categorical Scale	51; 17	—
SECONDARY The Time to Extubation	—	—

Summary

Emergence agitation is a major concern in patients undergoing orthognathic surgery. The patients may experience the sense of suffocation during emergence due to nasotracheal intubation and orofacial edema. Postoperative pain is also associated with emergence agitation. Although there is a lot of studies about emergence agitation in children, there is a few in adults, furthermore, no data about comparison of emergence agitation between sevoflurane and desflurane anesthesia in adults. Therefore, the investigators would like to compare the incidence and severity of emergence agitation between sevoflurane and desflurane anesthesia in adults after orthognathic surgery.

Eligibility Criteria

Inclusion Criteria

American Society of Anesthesiologists(ASA) physical status classification 1 or 2 patients
patients scheduled for orthognathic surgery

Exclusion Criteria

severe cardiopulmonary disease
psychological disease
patients who cannot understand Korean

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Data sourced from ClinicalTrials.gov (NCT01878656). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.