N/A N=121 Emergence Agitation Between Dexmedetomidine and Sevoflurane Anesthesia
Emergence Delirium
Primary: Emergence Agitation — 3.9; 2.5 Score on a scale — p=0.001
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=99 Propofol in Emergence Agitation
Emergence Agitation
Primary: Number of Participants With Emergent Agitation — 16; 24 Participants
N/A N=36 Emergence From Anesthesia in Anterior Temporal Lobectomy and Amygdalohippocampectomy Patients
Emergence From Anesthesia
Primary: Volumes of the Hippocampus, Thalamus and Amygdala — 3578; 3903; 3479; 3525 mm3
N/A N=104 Effect of Monochromatic Light on Incidence of Emergence Delirium in Children
Emergence Delirium · Anesthesia Emergence Delirium
Primary: Number of Participants With Emergence Delirium Following Anesthesia in Children — 17; 3 Participants — p=0.001
N/A N=68 Anesthetic Depth and the Incidence of Emergence Agitation in Children Undergoing Strabismus Surgery
Strabismus
Primary: the Pediatric Anesthesia Emergence Delirium (PAED) Score — 12.5; 11.4; 6.5; 5.4 score on a scale
Phase 4 N=144 Comparison of Emergence Agitation Between Sevoflurane and Desflurane Anesthesia After Orthognathic Surgery
Emergence Agitation
Primary: The Incidence of Emergence Agitation Using Four-point Categorical Scale — 51; 17 participants
N/A N=68 Comparison of Effects of Intravenous Midazolam and Ketamine on Emergence Agitation
Psychomotor Agitation
Primary: Emergence Agitation — 6; 0 participants
Phase 1 N=54 General Anesthesia Emergence Induced by Methylphenidate
Delayed Emergence From Anesthesia
Primary: Emergence Time — 9; 9 minutes
N/A N=40 The Effect of Depth of Anesthesia as Measured by Bispectral Index (BIS) on Emergence Agitation in Children
Emergence Agitation
Primary: Peak Pediatric Assessment of Emergence Delirium (PAED) Score Within the First 30 Minutes of Reaching the Recovery Room (Post-Anesthesia Care Unit) — 8.6; 6.7 units on a…
Phase 3 N=400 Dexmedetomidine as a Rapid Bolus in Children for Emergence Agitation
Tonsillectomy
Primary: Heart Rate (HR) — 120; 121; 107; 121 bpm — p=<0.01
Phase 2 N=32 Reversal of General Anesthesia With Methylphenidate
Post Operative Cognitive Dysfunction · Emergence From Anesthesia
Primary: Number of Participants With Adverse Events — 0; 0 Participants
Phase 4 N=40 Effect of Sugammadex vs. Neostigmine/Glycopyrrolate on Pediatric Emergence Delirium in Sevoflurane-rocuronium Anesthesia
Emergence Delirium
Primary: Pediatric Anesthesia Emergence Delirium Score — 18; 18 units on a scale
Phase 4 N=80 Dexmedetomidine to Prevent Agitation After Free Flap Surgery
Agitation · Delirium
Primary: Agitation in PACU — 15; 18; 4; 12 participants
Phase 3 N=28 Use of Dexmedetomidine to Reduce Emergence Delirium Incident in Children
Agitation · Anesthesia · Pediatrics
Primary: Number of Participants With Emergence Delirium — 1; 7; 13; 7 participants
Phase 4 N=120 Treating Acutely Agitated Patients With Asenapine Sublingual Tablets
Agitation
Primary: Positive and Negative Syndrome Scale - Excited Component — 7.86; 14.93 PANSS SCORE
Phase 3 N=380 Dexmedetomidine in the Treatment of Agitation Associated With Bipolar Disorder
Agitation Associated With Bipolar Disorder · Agitation,Psychomotor · Bipolar Disorder
Primary: Change From Baseline in the Positive and Negative Syndrome Scale- Excited Component (PEC) Total Score — 18.0; 18.0; 17.9; -10.4 score on a scale — p=<0.0001
Early Phase 1 N=143 Emergence Agitation and Pain Scores in Pediatrics When Comparing Single-modal vs Multi-modal Analgesia for ENT Surgery
Emergence Agitation · Pain
Primary: Emergence Agitation (EA) as Measured by Standardized PAED Scale — 5.3; 4.99; 6.29 score on a scale
N/A N=109 Post Extubation Delirium and End-tidal Sevoflurane Concentration
Delirium on Emergence
Primary: Number of Participants With Emergence Delirium (ED) — 5; 23 Participants — p=0.003
Phase 3 N=380 Dexmedetomidine in the Treatment of Agitation Associated With Schizophrenia
Agitation · Schizophrenia · Schizo Affective Disorder
Primary: Change From Baseline in the Positive and Negative Syndrome Scale- Excited Component (PEC) Total Score — 17.5; 17.6; 17.6; -8.4 score on a scale — p=<0.0001
Phase 1 N=52 Nicardipine vs Esmolol Craniotomy Emergence
Brain Tumors
Primary: Failure of Drug to Control Systolic Blood Pressure (SBP) < 140 mmHg — 1; 11 participants
N/A N=206 EmergeNcy Department Apneic Oxygenation Versus Usual Care During Rapid Sequence Intubation
Diffuse Apneic Oxygenation
Primary: Mean (Average) Arterial Oxygen Saturation — 92; 93 Percent Saturation (SpO2)
Phase 4 N=72 A Comparison Study of the Efficacy of Quetiapine and Haloperidol in Agitated Adults in Emergency Room
Agitation
Primary: Change in the PANSS-EC Score Among Participants From Baseline to 2 Hours After Administration of the Medication. — -11.0; -11.5 score on a scale — p=>0.05
Phase 3 N=151 Dexmedetomidine in the Treatment of Agitation Associated With Dementia (TRANQUILITY II)
Agitation · Dementia
Primary: Absolute Change From Baseline in Positive and Negative Syndrome Scale- Excited Component (PEC) Total Score for the First Episode of Agitation — -5.7; -7.5; -5.4 score on…
N/A N=498 Delirium in the Emergency Department: Novel Screening
Delirium
Primary: Delirium — 98.0; 56.2; 56.2; 54.8 percent
N/A N=10 Phamacological Reversal of Airway Instability During Sedation
Upper Airway Obstruction
Primary: AHI - Apnea Hypopnea Index — 14.5; 27.9; 11.3; 12.1 events per hour
N/A N=20 Inhaled Nitrous Oxide for the Prevention of Emergence Reaction During Ketamine Administration in Adults, a Pilot Study
Emergence Reaction · Procedural Sedation
Primary: Emergence Reaction
Phase 4 N=80 Single Dose Tramadol Effect on Extubation Response and Quality of Emergence Post-supratentorial Intracranial Surgery
Brain Neoplasm
Primary: Haemodynamic Parameters at the Time of Emergence and Postextubation — 128.55; 132.34; 132.63; 134.29 mm Hg
Phase 2 N=20 Optimization of Desflurane in Elderly Patients
Postoperative Cognitive Dysfunction
Primary: The Time From the End of Anesthesia to Extubation — 329.0; 636.0 second
N/A N=24 Alzheimer's in Long-Term Care--Treatment for Agitation
Alzheimer Disease · Psychomotor Agitation
Primary: Mean Clinical Global Impression of Change (CGIC) at Last Observation — 2.6; 4.5 units on a scale
Phase 4 N=63 Efficacy of Single-Shot Dexmedetomidine Versus Placebo in Preventing Pediatric Emergence Delirium in Strabismus Surgery
Strabismus · Delirium on Emergence · Pediatric Disorders
Primary: Percentage of Patients Experiencing Pediatric Emergence Delirium in Strabismus Surgery — 50; 48 percentage of participants