N/A
N=99
Evaluating Two Types of Cognitive Training in Veterans With Schizophrenia
Schizophrenia
Bottom Line
View on ClinicalTrials.gov: NCT01891721 ↗Enrolled (actual)
99
Serious AEs
0.0%
Results posted
Aug 2019
Primary outcome: Primary: Neurocognition — 42.02; 41.92; 41.94 score on a scale
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Brain Fitness Program (BFP) (Behavioral); Cognitive Package (Cogpack) (Behavioral); Commercial Computer Games (Sporcle) (Behavioral)
- Age
- Adult, Older Adult · 25+ yrs
- Sex
- All
- Sponsor
- VA Office of Research and Development
- Primary completion
- Jun 2018
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Neurocognition |
42.02; 41.92; 41.94 | — |
| SECONDARY Electroencephalography (EEG) |
-2.04; -2.17; -2.09; -1.78; -2.16; -2.21 | — |
| SECONDARY Functional Capacity |
76.50; 75.96; 76.77 | — |
Summary
Cognitive dysfunction is a major contributor to the poor community outcome of individuals with schizophrenia. Developing more effective cognitive remediation interventions is imperative to improve the daily lives of affected subjects and reduce the disability of this illness. The goal of this clinical trial is to evaluate two types of cognitive training approaches to determine which one is more beneficial for individuals with schizophrenia. This study also uses electrophysiological techniques to gain a better understanding of the mechanisms involved in cognitive remediation. Findings from this study will provide information about how to design the most optimally efficient cognitive training intervention to improve the cognitive and social functioning of patients with severe mental illness.
Eligibility Criteria
Inclusion Criteria
- Veterans with a Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) diagnosis of schizophrenia or schizoaffective disorder
- Between 25 and 65 years of age
- Estimated premorbid inteIligence quotient (IQ) > 70 (based on reading ability)
- Understand spoken English sufficiently to comprehend the consent form
- Clinically stable (i.e., no inpatient hospitalization in the 3 months, no changes in psychiatric medications in the 6 weeks, and no changes in housing in the 2 months, prior to enrollment)
Exclusion Criteria
- Documented history of mental retardation or severe learning disability
- Clinically significant neurological disease as determined by medical history (e.g., epilepsy, stroke)
- History of serious head injury with loss of consciousness greater than 1 hour and concomitant neuropsychological sequelae
- Meeting DSM-IV criteria for drug or alcohol dependence during the 6 months, or abuse during the month preceding study enrollment
Data sourced from ClinicalTrials.gov (NCT01891721). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.