N/A
Completed N=11
The Effect of rTMS Treatment on Alzheimer's and Sleep Quality
Source: ClinicalTrials.gov NCT01894620 ↗Enrolled (actual)
11
Serious AEs
0.0%
Results posted
Feb 2018
Primary outcomePrimary: Cognitive Improvement Measured Using Montreal Cognitive Assessment (MoCA) — -0.667; 1.8 MOCA score change at 2 weeks
Summary
This research is being conducted to study whether rTMS (repetitive Transcranial Magnetic Stimulation) could be potentially used as a treatment for Alzheimer's disease. rTMS is a technique that stimulates the brain by rapidly switching a magnetic field in a coil placed over your head. Prior to rTMS, single pulse TMS will be used to localize the specific brain region that we are interested in.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Cognitive Improvement Measured Using Montreal Cognitive Assessment (MoCA) |
-0.667; 1.8 | — |
| SECONDARY Improvement in Sleep Quality |
— | — |
Eligibility Criteria
Inclusion Criteria
- Individuals must have a MoCA score between 5 and 26, indicating mild cognitive impairment or dementia.
- Participants must have probable early or moderate Alzheimer's disease as confirmed by their treating neurologist or psychiatrist, and/or by the co-investigators.
Exclusion Criteria
- A recent (the last 3 months) history of stroke, recent (the last 3 months) head injury and loss of consciousness, any history of epilepsy, seizures, multiple sclerosis (MS), Amyotrophic Lateral Sclerosis (ALS), or Autism.
- Recent changes in medication (i.e. patients should be in a relatively stable phase of disease).
- The presence of metallic objects in the body; dental implants are fine but people with pacemakers are to be excluded; basically anything that is unsafe under MRI would be considered unsafe for TMS application.
Data sourced from ClinicalTrials.gov (NCT01894620). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.