Phase 4
Completed N=273
Liraglutide Hospital Discharge Trial
Source: ClinicalTrials.gov NCT01919489 ↗Enrolled (actual)
273
Serious AEs
38.8%
Results posted
Nov 2021
Primary outcomePrimary: Glycemic Control at Hospital Discharge and 6 Months Follow up — 8.3; 8.4; 7.13; 7.68 % (mmol/mol)
◆ Published Evidence
No publication linked
No peer-reviewed publication reporting this trial's results has been linked yet. This can indicate results are unpublished — a known publication-bias signal. We re-check periodically.
Summary
High blood glucose levels in hospitalized patients with diabetes are associated with increased risk of medical complications and death. Improved glucose control with insulin injections may improve clinical outcome and prevent some of the hospital complications. Increasing evidence indicates that incretin-based agents are safe and effective for the hospital management of patients with type 2 diabetes (T2D).
Liraglutide is a once-daily human glucagon-like peptide (GLP-1) analogue approved for the treatment of T2D. Liraglutide has been shown to lower blood glucose, stimulate endogenous insulin secretion, decrease plasma glucagon levels, inhibit gastric emptying, reduce food intake and body weight and improve ß-cell function when administered subcutaneously. Liraglutide increases insulin secretion in a glucose-dependent manner (i.e., only when plasma glucose levels are elevated), resulting in low-risk of hypoglycemia when used as monotherapy. When compared to insulin glargine therapy, the use of GLP-1 has resulted in comparable reduction in HbA1c level, lower rates of hypoglycemia and less weight gain. No prospective studies; however, have compared the efficacy and safety of liraglutide in the hospital setting or after hospital discharge.
The primary objective is to compare the safety and efficacy of liraglutide (Victoza®) versus glargine insulin in combination to oral anti-diabetic agents (OADs: metformin, sulfonylureas, nateglinide, repaglinide or pioglitazone) on glycemic control after 26 weeks of treatment in medicine patients with T2D after hospital discharge.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Glycemic Control at Hospital Discharge and 6 Months Follow up |
8.3; 8.4; 7.13; 7.68 | — |
| SECONDARY Fasting and Postprandial Blood Glucose (BG) Concentration After Follow up of 26 Weeks |
7.61; 8.56; 7.67; 9.32; 8.23; 8.72 | — |
| SECONDARY Hypoglycemic Episodes |
18; 31; 2; 3 | — |
| SECONDARY HbA1c <7.0% and no Hypoglycemia |
40; 31 | — |
| SECONDARY HbA1c <7.0% and no Weight Gain |
32; 21 | — |
| SECONDARY Change in Body Weight From Baseline |
101.0; 98.2; 97.2; 98.3; -4.77; 0.6 | — |
| SECONDARY Change in BMI |
33.5; 33.3; 32.7; 33.3 | — |
| SECONDARY Total Daily Dose of Insulin |
0; 20.9 | — |
| SECONDARY Change in Cardiovascular Risk Factors: Blood Pressure |
134; 130; 136; 135; 79; 77 | — |
| SECONDARY Cardiovascular Risk Factor: Heart Rate |
79; 79; 83; 79 | — |
| SECONDARY Cardiovascular Risk Factor: Lipid Profile |
190; 130 | — |
| SECONDARY Emergency Room Visits and Readmissions |
31; 23; 35; 43 | — |
| SECONDARY Acute Renal Failure |
1; 3 | — |
| SECONDARY Self-measured Blood Glucose (SMBG) 7-point Profiles at 26 Weeks Follow up |
34; 34 | — |
Eligibility Criteria
Inclusion Criteria
- Males or females between the ages of 18 and 80 years discharged after hospital admission from non- ICU general surgery and medicine services (excluding gastrointestinal and cardiac surgeries).
- Admission HbA1c between 7% and 10%
- Patients with T2D treated with diet alone or with oral antidiabetic agents as monotherapy or in combination therapy (excluding GLP1 receptor agonists) or on low-dose insulin therapy (TDD ≤0.4 unit/kg/day) prior to admission.
- Subjects with a hospital admission BG 25 Kg/m2 and ≤ 45 Kg/m2
Exclusion Criteria
- Age 80 years.
- Subjects with stress hyperglycemia (BG > 140 mg/dL and HbA1c 3 times upper limit of normal, or significantly impaired renal function (GFR < 30 ml/min).
- Treatment with oral or injectable corticosteroid (equivalent or higher than prednisone 5mg/day), parenteral nutrition, and immunosuppressive treatment.
- Mental condition rendering the subject unable to understand the nature, scope, and possible consequences of the study.
- Female subjects who are pregnant or breastfeeding at the time of enrollment into the study.
- Females of childbearing potential who are not using adequate contraceptive methods (as required by local law or practice).
Data sourced from ClinicalTrials.gov (NCT01919489). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.