N/A
N=37
Predictors of Treatment Outcome With Cognitive Behavioral Therapy for Depression
Major Depressive Disorder
Bottom Line
View on ClinicalTrials.gov: NCT01922219 ↗Enrolled (actual)
37
Serious AEs
0.0%
Results posted
Mar 2017
Primary outcome: Primary: Remitters as Assessed by Post-treatment Beck Depression Inventory Less Than or Equal to 10 — 13 Participants
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Cognitive Behavioral Therapy (Behavioral)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- New York State Psychiatric Institute
- Primary completion
- Aug 2015
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Remitters as Assessed by Post-treatment Beck Depression Inventory Less Than or Equal to 10 |
13 | — |
| SECONDARY Post-Treatment Beck Depression Inventory |
15.4 | — |
| SECONDARY Final Score on the Hamilton Depression Rating Scale |
13.41 | — |
Summary
The purpose of this research study is to learn whether specific types of brain imaging and psychological testing can predict how much benefit patients with depression will receive from a well-studied psychotherapy for depression, called cognitive behavioral therapy (CBT), and how the brain imaging and psychological tests change with treatment. We will also be comparing brain scans from this study between individuals suffering from depression and volunteers without depression.
This study offers 14 sessions of one-on-one cognitive-behavioral therapy (CBT) over twelve weeks, administered by an experienced doctoral-level psychologist or psychiatrist.
Eligibility Criteria
Inclusion Criteria
- In a current major depressive episode
- If currently on medications, lack of benefit after an adequate trial. If currently on medications, willing and able to tolerate a medication washout.
- Ability to provide an informed consent
- For healthy volunteers, no current or past history of depression
Exclusion Criteria
- Unstable medical conditions
- Current alcohol or substance abuse or dependence
- Current or past history of other major psychiatric disorders such as Bipolar disorder, schizophrenia, or other psychotic illnesses (Anxiety in depressed participants is okay)
- For females, current pregnancy
- Dementia or neurological disease or head trauma with evidence of cognitive impairment
- Currently taking fluoxetine
- Contraindication to CBT
- Presence of metal in body
- Claustrophobia
- Weight > 350 pounds
Data sourced from ClinicalTrials.gov (NCT01922219). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.