Phase 4
Completed N=62
Comparison of Deep Extubation During Emergence Using Desflurane or Desflurane With Remifentanil in Patients Undergoing General Anesthesia
Deep Extubation
Source: ClinicalTrials.gov NCT01924871 ↗
Enrolled (actual)
62
Serious AEs
0.0%
Results posted
May 2014
Primary outcomePrimary: Awakening Time — 10; 7 minutes
Summary
It has been reported that deep extubation can reduce cardiopulmonary complication against endotracheal tube extubation during emergence from general anesthesia. The investigators hypothesized that using desflurane with target controlled infusion of remifentanil is more effective than using desflurane alone during deep extubation. The purpose of this study is to evaluate the effect of remifentanil to prevent respiratory complication (etc. coughing) during emergence from general anesthesia.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Awakening Time |
10; 7 | — |
| SECONDARY Success Rate & Complication Rate Including Cough |
— | — |
Eligibility Criteria
Inclusion Criteria
- Age 20-60
- patients undergoing elective surgery take more than an hour
- Under general anesthesia using an LMA
- ASA I,II
Exclusion Criteria
- Patients on CNS depressants
- Chronic opioid use
- Corticosteroid
- Pregnant patients
- Full stomach
- Morbidly obese (BMI >35kg/m2)
- Hepatitis B
- Hepatitis C
- Coronary artery disease
- Liver disease
- Renal disease
- Seizure disorder
Dropout criteria:
- Need for reintubation due to breath holding
- high ETCO2 during self ventilation (ETCO2>50)
- Surgeon or patient request
Data sourced from ClinicalTrials.gov (NCT01924871). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.