Phase 4 N=62 Comparison of Deep Extubation During Emergence Using Desflurane or Desflurane With Remifentanil in Patients Undergoing General Anesthesia
Deep Extubation
Primary: Awakening Time — 10; 7 minutes
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Phase 1 N=30 Extubation Advisor: Initial Implementation and Evaluation of a Novel Extubation Clinical Decision Support Tool
Airway Extubation
Primary: Evaluate Feasibility of Enrolling and Consenting Greater Than 50% of Eligible Patients — 30 Participants
N/A N=67 Extubation With or Without Spontaneous Breathing Trial
Respiratory Failure
Primary: Number of Participants With Successful Extubation, Reintubation and in Hospital Mortality — 28; 29; 3; 3 participants — p=>0.05
Phase 4 N=50 A Low Dose Remifentanil Infusion During Tracheal Extubation in Surgical Intensive Care Unit Patients
Tracheal Extubation
Primary: Mean Arterial Pressure Changes During Extubation — 94; 97; 96; 97 mmHg
N/A N=52 Extubation Readiness and Neuroventilatory Efficiency After Acute Respiratory Failure
Respiratory Failure
Primary: Neuroventilatory Efficiency (NVE) — 17.6; 39.9 ml/uV — p=<0.05
N/A N=470 Rest After Spontaneous Breathing Trial for Prevention of Post-extubation Failure
Weaning Failure
Primary: Number of Patients With Extubation Failure — 58; 24 Participants
N/A N=751 Protocolized Post-Extubation Respiratory Support Study
Mechanical Ventilation Complication · Acute Respiratory Failure · Intubation Complication
Primary: Reintubation — 57; 52 Participants
N/A N=23 Dexmedetomidine Versus Midazolam for Facilitating Extubation
Critical Illness
Primary: Time From Study Drug Initiation to Tracheal Extubation — 2.9; 3.4 days — p=0.8
Phase 4 N=195 Does Deflating the Tracheal Cuff Shorten Weaning Time?
Weaning · Tracheostomy
Primary: Weaning Time — 4.95; 10.15; 4.95; 10.15 day
N/A N=62 Impact of the Inspiratory Cortical Control on the Outcome of the Ventilatory Weaning Test in Patients Intubated in Resuscitation
Respiration Disorder · Respiratory Failure · Weaning Failure
Primary: Magnitude of Inspiratory Premotor Potentials — 1.2; 2.1 µV
Phase 4 N=302 Residual Curarization and Its Incidence at Tracheal Extubation (P08194)
Observation of Neuromuscular Block
Primary: Percentage of Participants With Residual Neuromuscular Blockade (NMB)(Train of Four [TOF] Ratio <0.9) at Time of Tracheal Extubation — 56 percentage of participants
N/A N=65 Assessment of an Endotracheal Tube Securement Device
Respiratory Insufficiency
Primary: Prevention of Damage and/or Occlusion of Endotracheal (ET) Tube During Use — 0; 1 participants
N/A N=90 Tracheal Palpation of Sliding Cuff to Assess Endotracheal Tube Location
Anesthesia Intubation Complication
Primary: Sore Throat — 1.5; 0.6 units on a scale — p=0.04
N/A N=181 Determining the Depth of Endotracheal Tube Insertion
Endotracheal Intubation · Individualized Depth of Endotracheal Intubation
Primary: Comparison of Airway Length Between Male and Female — 0.9; 1.1; 9.1; 8.3 Centimeters
N/A N=150 Facilitating EndotracheaL Intubation by Laryngoscopy Technique and Apneic Oxygenation Within the Intensive Care Unit: The FELLOW Study
Respiratory Failure
Primary: Successful First Attempt at Endotracheal Intubation (Defined by Confirmed Placement of an Endotracheal Tube in the Trachea During First Laryngoscopy Attempt) After…
N/A N=170 Intubating Conditions of Neuromuscular Blockade
Endotracheal Intubation
Primary: Number of Subjects With Optimal Intubating Conditions — 61; 47 Participants — p=0.036
N/A N=20 Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) and Short Laryngologic Surgery
Laryngologic Surgical Procedures
Primary: Average Oxygen Saturation by Pulse Oximetry (SpO2) (Primary Anesthesia Outcome) — 93; 98.7 percentage of saturation (SpO2) — p=0.006
Phase 4 N=79 Use of Sugammadex for Reversal of Paralysis in Microlaryngoscopy
Microlaryngoscopy · Rigid Bronchoscopy
Primary: Time to Extubation After End of Procedure — 11.06; 10.36 Minutes
N/A N=77 Non-invasive Ventilation vs Oxygen Therapy After Extubation Failure
Respiratory Failure
Primary: Rate of Intubation — 10; 23 participants
N/A N=50 VivaSight Double Lumen Tube for Single Lung Ventilation
Double Lumen Endotracheal Tube · Single Lung Ventilation
Primary: Number of Participants Requiring Flexible Fiberoptic Bronchoscopy — 25; 7 Participants
N/A N=37 Clamping the Double Lumen Tube
One-lung Ventilation
Primary: T50-3 — 31.87; 63.81; 33.30; 60.82 minutes
N/A N=20 Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) and Diagnostic Bronchoscopy
Bronchoscopy
Primary: Lowest Intraoperative Peripheral Oxygen Saturation (SpO2) — 94.7; 98.7 percentage of oxygen — p=0.09
N/A N=100 No Post Intubation Laryngeal Symptoms
Sore-throat · Dysphonia · Dysphagia
Primary: Sore Throat on a Scale From 0 (no Sore Throat) to 10 (Worst Possible Sore Throat) — 1.85; 1.9; 1.1; 1.62 score on a scale — p=0.03
N/A N=20 Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) and Laser Laryngeal Surgery
Otorhinolaryngologic Surgical Procedures · Laser Therapy
Primary: Lowest Intraoperative Peripheral Oxygen Saturation (SpO2) — 97; 97 percentage of oxygen — p=0.7934
N/A N=269 Evaluation of a Systematic Approach to Weaning From Mechanical Ventilation
Weaning Failure · Complication of Respirator [Ventilator]
Primary: Mortality — 10; 14 participants — p=0.03
Phase 4 N=142 Effect of Single-dose Dexmedetomidine on Airway Reflex in Adult With Oral Intubation After Thyroidectomy
Coughing
Primary: Coughing Grade — 0.6; 1.4 units on a scale
N/A N=513 Oral Suction Intervention to Reduce Aspiration and Ventilator Events: NO-ASPIRATE
Respiratory Failure
Primary: Microaspiration as Measured by Tracheal Amylase — 13,086; 15,298 U/L — p=0.432
Phase 4 N=80 Single Dose Tramadol Effect on Extubation Response and Quality of Emergence Post-supratentorial Intracranial Surgery
Brain Neoplasm
Primary: Haemodynamic Parameters at the Time of Emergence and Postextubation — 128.55; 132.34; 132.63; 134.29 mm Hg
Phase 2 N=6 Extracorporeal Membrane Oxygenation (ECMO) in Non-intubated Patients With Acute Respiratory Distress Syndrome (ARDS)
ARDS
Primary: Number of Participants That Did Not Require Endotrachael Intubation — 3 participants
Phase 4 N=90 Sugammadex and Decreased Time to Extubation
Coronary Artery Bypass Graft and/or Aortic Valve Replacement Surgery
Primary: Time to Extubation — 126.0; 219.0 minutes