N/A N=11 Randomized Single-blind Basic Science

Investigating Brown Adipose Tissue Activation in Humans

Metabolic Diseases

Bottom Line

View on ClinicalTrials.gov: NCT01935791 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

May 2021

Primary outcome: Primary: Brown Adipose Tissue Activation Following Glucagon or Saline Infusion — 0.074; 0.010; 0.029 MR[gluc] umol/kg/min — p=<0.01

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Period 1 Visit 1 - Cold PET-CT Vehicle, Visit 2 -Warm PET-CT Vehicle (Other); Period 1 Visit 1 - Cold PET-CT Vehicle, Visit 2 -Warm PET-CT Glucagon (Drug); Period 1 Visit 1 - Cold PET-CT Vehicle, no visit 2 as BAT negative (Other); Period 2 - Visit 1 Warm Control vehicle, Visit 2 Warm Glucagon, Visit 3 Cold control (Drug); Period 2 - Visit 1 Warm Glucagon, Visit 2 Cold control , Visit 3 Warm control (Drug); Period 2 -Visit 1 cold control, Visit 2 warm control, Visit 3 Warm glucagon (Drug); Period 2 -Visit 1 cold control, visit 2 warm glucagon, visit 3 warm control (Drug); Period 2- Visit 1 Warm glucagon, visit 2 warm control, visit 3 cold control (Drug); Period 2 - Visit 1 Warm control, visit 2 cold control, visit 3 warm glucagon (Drug)
Age: Adult, Older Adult · 18+ yrs
Sex: All
Sponsor: Imperial College London
Primary completion: Nov 2018

Outcome Measures

Outcome	Result	p-value
PRIMARY Brown Adipose Tissue Activation Following Glucagon or Saline Infusion	0.074; 0.010; 0.029	<0.01 sig
PRIMARY Increase in Energy Expenditure Following Glucagon or Saline Infusion	193.0; 41.1; 230.8	<0.001 sig

Summary

The purpose of this study is to determine what can activate brown adipose tissue (BAT).

Eligibility Criteria

Inclusion Criteria

aged >18 years

Exclusion Criteria

medical conditions
recreational drug use
participation in other trials within the preceding 2 months
blood donation within 3 months of study participation

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01935791). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.