N/A
Completed N=1,533
The Possible Correlations Between the Genes Related to Pain Sensation and the Pain Sensitivity in the General Population
Postoperative Pain · Surgery
Source: ClinicalTrials.gov NCT01950078 ↗
Enrolled (actual)
1,533
Serious AEs
0.0%
Results posted
Feb 2015
Primary outcomePrimary: Preoperative Pressure Pain Threshold (PPT) — 2.33; 3.24 kg/cm2
Summary
Objective: This study was conducted to explore the possible correlation between some gene related to pain sensation and individual basal pain perception and postoperative pain intensity in the general population. Methods: Patients receiving elective surgery under general anesthesia were recruited into this study. The investigators measured their preoperative pressure pain threshold (PPT) and pressure pain tolerance (PTO). Pain intensity at rest and movement after the operation was evaluated . And the PCA drug consumption were recorded. Also there were healthy college students volunteer be recruited into this study. The investigators measured their experimental pain sensitivity including pressure pain threshold (PPT) and pressure pain tolerance (PTO), etc. Then genotyping was carried out.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Preoperative Pressure Pain Threshold (PPT) |
2.33; 3.24 | — |
| SECONDARY Preoperative Pressure Pain Tolerance (PTO) |
4.65; 6.38 | — |
Eligibility Criteria
Inclusion Criteria
- •Aged 18-65 years
- Receiving elective gynecological laparoscopic surgery
- Anesthesiologists (ASA) physical status I or II
- Agreed to participate the research
Exclusion Criteria
- •History of chronic pain
- Psychiatric diseases
- Diabetes mellitus
- Severe cardiovascular diseases
- Kidney or liver diseases
- Alcohol or drug abuse
- Heavy smoker
- Pregnancy or at lactation period
- Disagree to participate to the research
Data sourced from ClinicalTrials.gov (NCT01950078). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.