N/A N=1,533

The Possible Correlations Between the Genes Related to Pain Sensation and the Pain Sensitivity in the General Population

Pain · Surgery

Bottom Line

View on ClinicalTrials.gov: NCT01950078 ↗

Enrolled (actual)

1,533

Serious AEs

0.0%

Results posted

Feb 2015

Primary outcome: Primary: Preoperative Pressure Pain Threshold (PPT) — 2.33; 3.24 kg/cm2

Study Design & Population

Study type: Observational
Phase: N/A
Interventions: —
Age: Adult, Older Adult · 18+ yrs
Sex: All
Sponsor: Xianwei Zhang
Primary completion: Aug 2014

Outcome Measures

Outcome	Result	p-value
PRIMARY Preoperative Pressure Pain Threshold (PPT)	2.33; 3.24	—
SECONDARY Preoperative Pressure Pain Tolerance (PTO)	4.65; 6.38	—

Summary

Objective: This study was conducted to explore the possible correlation between some gene related to pain sensation and individual basal pain perception and postoperative pain intensity in the general population. Methods: Patients receiving elective surgery under general anesthesia were recruited into this study. The investigators measured their preoperative pressure pain threshold (PPT) and pressure pain tolerance (PTO). Pain intensity at rest and movement after the operation was evaluated . And the PCA drug consumption were recorded. Also there were healthy college students volunteer be recruited into this study. The investigators measured their experimental pain sensitivity including pressure pain threshold (PPT) and pressure pain tolerance (PTO), etc. Then genotyping was carried out.

Eligibility Criteria

Inclusion Criteria

•Aged 18-65 years
Receiving elective gynecological laparoscopic surgery
Anesthesiologists (ASA) physical status I or II
Agreed to participate the research

Exclusion Criteria

•History of chronic pain
Psychiatric diseases
Diabetes mellitus
Severe cardiovascular diseases
Kidney or liver diseases
Alcohol or drug abuse
Heavy smoker
Pregnancy or at lactation period
Disagree to participate to the research

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01950078). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.