N/A
Completed N=220
Race And CPAP Effectiveness
Sleep Apnea Syndromes
Source: ClinicalTrials.gov NCT01960465 ↗
Enrolled (actual)
220
Serious AEs
0.0%
Results posted
Nov 2020
Primary outcomePrimary: 24 Hour Ambulatory Blood Pressure — -1.93; -0.64; -1.38; -1.19 mm Hg
Summary
Obstructive sleep apnea (OSA) is a major public health problem in the U.S. and more than 35% of Veterans are at high risk for OSA. OSA is associated with progression of hypertension, an important health problem in Veterans. African Americans with OSA are at increased risk for poorly controlled hypertension and its health consequences. Implementing a care plan to increase the percentage of Veterans in whom blood pressure goals are achieved has been prioritized by Veterans Administration hospitals. Recent studies show that hypertension control can be improved with continuous positive airway pressure (CPAP) treatment of OSA. The aim of this proposal is to examine and compare the effects of CPAP treatment on 24-hour arterial blood pressure and central aortic blood pressure (measured non-invasively with a cuff on the upper arm) in African American and other Veterans.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY 24 Hour Ambulatory Blood Pressure |
-1.93; -0.64; -1.38; -1.19 | — |
| SECONDARY Central Aortic Blood Pressure |
-0.20; -0.23; -1.20; -0.68 | — |
| SECONDARY Urinary Sympathetic Activity (Catecholamines) and Oxidative Stress (8-isoprostane) |
0.02; -0.26; -3.7; -2.7 | — |
Eligibility Criteria
Inclusion Criteria
- Self-identified African American and other Veterans (of self-identified race other than African American)
- Age: 30-70 years
- Hypertension
- Apnea hypopnea index (AHI) 15/hour on home sleep apnea test
Exclusion Criteria
- Past/current treatment of Obstructive Sleep Apnea or other primary sleep disorders
- Active uncontrolled medical conditions
- Shift work in past 6 months
- Current drug use
- Pregnancy
Data sourced from ClinicalTrials.gov (NCT01960465). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.