N/A
N=150
Stress CT Perfusion in Patients With Chest Pain
Coronary Artery Disease
Bottom Line
View on ClinicalTrials.gov: NCT01969916 ↗Enrolled (actual)
150
Serious AEs
0.0%
Results posted
Feb 2019
Primary outcome: Primary: Number of Participants With Detected Stress-induced Perfusion Abnormalities by 3D Analysis of MDCT Images — 56 Participants
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Regadenoson (Drug)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- University of Chicago
- Primary completion
- Jun 2018
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Number of Participants With Detected Stress-induced Perfusion Abnormalities by 3D Analysis of MDCT Images |
56 | — |
Summary
Our hypothesis is that quantitative 3D analysis of cardiac CT images obtained during vasodilator stress can accurately identify patients presenting at the emergency department with acute chest pain due to underlying hemodynamically significant coronary stenosis, aid in the identification of individuals most likely to benefit from revascularization, and thus improve the ability to predict patient outcomes.
Our goals are:
1. to test the above hypothesis by comparing stress MDCT perfusion data with invasive fractional flow reserve (FFR) data in patients with significant stenosis who undergo ICA;
2. to determine the added value of MDCT perfusion as an adjunct to CTCA for predicting patient outcomes.
Eligibility Criteria
Inclusion Criteria
- patients with chest pain referred for CT coronary angiography
Exclusion Criteria
- allergy to iodine,
- renal dysfunction (creatinine >1.6 mg/dL)
- chronic obstructive pulmonary disease
- advanced heart block
- or systolic blood pressure <90 mmHg
Data sourced from ClinicalTrials.gov (NCT01969916). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.