Phase 2
Completed N=55
The Effects of DHA on Periodontitis
Source: ClinicalTrials.gov NCT01976806 ↗Enrolled (actual)
55
Serious AEs
0.0%
Results posted
Mar 2014
Primary outcomePrimary: Change in Pocket Depth (mm) — -0.71; -0.54 mm — p=<0.05
Summary
The purpose of this study is to determine whether docosahexaenoic acid (DHA) is effective in the treatment of periodontitis in adults.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Pocket Depth (mm) |
-0.71; -0.54 | <0.05 sig |
| SECONDARY Change in Gingival Index (0-3) |
-0.26; -0.07 | — |
| SECONDARY Change in Plaque Index (0-3) |
-0.10; 0.07 | — |
| SECONDARY Sites With Bleeding on Probing (Yes/no) |
202; 227 | — |
| SECONDARY Gingival Crevicular Fluid High Sensitivity C-reactive Protein |
-7.3715; -3.1268 | — |
| SECONDARY Gingival Crevicular Fluid Interleukin-6 |
0.1422; -0.00226 | — |
| SECONDARY Gingival Crevicular Fluid Interleukin-1 Beta |
0.8775; 21.5816 | — |
| SECONDARY Serum High-sensitivity C-reactive Protein |
-0.3695; 0.7114 | — |
| SECONDARY Serum High-sensitivity Interleukin-6 |
0.3295; -0.0690 | — |
| SECONDARY Serum Soluble Vascular Cell Adhesion Molecule |
4.8829; 27.9409 | — |
| SECONDARY Urine N-Terminal Telopeptides |
103.3333; 61.8421 | — |
Eligibility Criteria
Inclusion Criteria
- age >40 years
- >20 natural teeth (excluding third molars)
- no orthodontic appliances
- periodontitis defined as >4 teeth with pocket probing depths >5 mm
Exclusion Criteria
- pregnancy
- diabetes
- severe chronic diseases
- gastrointestinal bleeding
- uncontrolled chronic diseases
- autoimmune disorders
- conditions requiring antibiotic prophylaxis
- warfarin
- clopidogrel
- antimicrobial therapy within 30 days
- chronic use of non-steroidal anti-inflammatory drugs (other than aspirin)
- omega-3 fatty acid use within 6 months
- loose teeth
- painful teeth
- periodontal abscess
- pocket depths >10 mm in >1 tooth
- periodontal therapy within the past two years
- allergy to aspirin
- allergy to fish oil
- allergy to corn oil
- allergy to soybean oil
Data sourced from ClinicalTrials.gov (NCT01976806). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.