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Home › Conditions › Gingivitis

Gingivitis

1 published article · Updated continuously

Clinical Trial Landscape

Clinical Trials for Gingivitis

42 trials tracked for Gingivitis: 14 in phase 3 or 4 and 3 with published results. The most-cited published study has 14 citations.

42Trials tracked
14Phase 3 & 4
0Recruiting
3With published results
Phase distribution
Phase 4 10 Phase 3 4 Phase 2 5 Phase 1 1 Other / NA 22
  1. Phase 4 Six Month Plaque and Gingivitis Study Using Colgate Total Toothpaste Completed · 14 cited
  2. Phase 3 A Phase 3 Clinical Study Investigating the Gingivitis Efficacy of a Test Dentifrice Containing Stannous Fluoride Completed · 13 cited
  3. Phase 4 A Clinical Study Investigating the Efficacy of a Stannous Fluoride Dentifrice in Improving Gingival Health After Twice Daily Use for 3 Weeks Completed · 11 cited
  4. Phase 4 The Clinical Investigation of Toothpaste as Compared to Toothpaste and Mouthwash in Reducing Plaque and Gingivitis: A Six-week Clinical Study in the US Completed
  5. Phase 4 Clinical Study Comparing Dental Plaque and Gingivitis Reduction After Using One of Three Oral Hygiene Multi-component Regimens (Using of a Manual Toothbrush, a Toothpaste and a Mouthwash) Completed
  6. Phase 4 Cetylpyridium Chloride (CPC) Based Chewing Gum and Gingivitis Completed
Show 36 more trials
  1. Phase 4 A Clinical Study to Evaluate the Efficacy of a Range of Dental/Denture Products for Improved Oral Health in Partial Denture Wearers Completed
  2. Phase 4 A Controlled Clinical Study to Determine the Gingivitis Benefit of Flossing Completed
  3. Phase 4 Compare Anti-inflammatory Dentifrices Completed
  4. Phase 4 Evaluate Inflammation Caused by Gingivitis in Adults Completed
  5. Phase 4 An Efficacy Study of Chlorhexidine Mouthwashes Completed
  6. Phase 3 A Controlled Clinical Study to Determine the Gingivitis Benefit of Flossing Completed
  7. Phase 3 Comparative Efficacy of a Toothpaste That Reduces Plaque and Gingivitis Completed
  8. Phase 3 The Clinical Efficacy of Three Oral Hygiene Regimens Using a Manual Toothbrush, Toothpaste and a Mouthwash in Controlling Dental Plaque and Gingivitis Completed
  9. Phase 2 The Effects of DHA on Periodontitis Completed
  10. Phase 2 Assessing Gingivitis of 3 Different Dentifrices Compared to a Negative Control. Completed
  11. Phase 2 Safety and Tolerability of Antiplaque Chewing Gum in a Gingivitis Population Completed
  12. Phase 2 Efficacy of ClōSYS® Sensitive Fluoride Toothpaste and ClōSYS® Sensitive Rinse Regimen on MGI, PI and BOP Completed
  13. Phase 2 A Proof-of-principle Clinical Study Investigating the Efficacy of an Experimental Dentifrice Containing Sodium Bicarbonate and Sodium Hyaluronate on Gingivitis Completed
  14. Phase 1 Dose-dependent Anti-inflammatory Effects of Vitamin D in a Human Gingivitis Model Completed
  15. N/A Curved Soft-Picks on Plaque Accumulation on Patients With Gingivitis Completed
  16. N/A Powertoothbrushing for Treating Gingivitis Completed
  17. N/A A Clinical Trial to Test the Effect of Marketed Mouth Rinses on Decreasing Plaque and Gum Inflammation Completed
  18. N/A A Study to Evaluate the Efficacy of a Stannous Fluoride Toothpaste With a Cetylpyridinium Chloride Mouthwash in Improving Gingival Health and Reducing Plaque Accumulation Completed
  19. N/A Efficacy and Safety Study of Interproximal Cleaning Modalities on Oral Health Completed
  20. N/A A Clinical Study Investigating the Effects of a Dentifrice Containing 0.454% Stannous Fluoride on Gingivitis Treatment and Plaque Reduction When Used Twice Daily for 12 Weeks Completed
  21. N/A Evaluation of the Efficacy and Safety of a Loop Stretchable Dental Floss Completed
  22. N/A SmartMouth Advanced Clinical Formula Clinical Research Design Protocol Completed
  23. N/A Potential of Stannous Fluoride Toothpaste to Reduce Gum Disease Completed
  24. N/A Evaluation of Toothbrush Bristles in Plaque Reduction Completed
  25. N/A Clinical Evaluation of the Efficacy of a Marketed Dentifrice on Plaque and Gingivitis Completed
  26. N/A A Clinical Study Investigating the Effect of an Experimental Toothpaste Containing Stannous Fluoride in Improving Gingival Health Completed
  27. N/A Efficacy of a Commercial Dentifrice Containing Ilex Rotunda Thunb Extract for Dental Plaque and Gingivitis Completed
  28. N/A Study of the Anti-Inflammatory Effects of Colgate Total® During an Experimental Gingivitis Model Completed
  29. N/A A Study to Determine the Effects of Adding an Experimental Device With Mouthrinse to Oral Care Regimen Completed
  30. N/A To Investigate the Gingivitis Efficacy of a Stannous Fluoride Dentifrice in a Chinese Population Completed
  31. N/A Measuring Efficacy of an Oral-Irrigator After Three Weeks of Use Completed
  32. N/A A Clinical Trial to Evaluate Long-term Efficacy and Safety of Lozenges Containing Lactobacilli Reuteri (Prodentis™) on Gingivitis Completed
  33. N/A Efficacy of an Antibacterial Toothpaste and Patients' Satisfaction Completed
  34. N/A Iranian Traditional Mouth Rinse Punica Granatum Pleniflora (Golnaar) in Treatment of Gingivitis in Diabetic Patients Completed
  35. N/A A Clinical Study Investigating the Effects of a Dentifrice Containing 67% Sodium Bicarbonate When Used Twice Daily for 12 Weeks on Gingivitis Treatment and Plaque Removal Completed
  36. N/A Oral Hygiene and Maternity Outcomes Multicenter Study (OHMOM) Completed

Showing the 42 most-cited and recently-updated of 42 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Gingivitis: what the trials found

Several pharmacological and mechanical interventions have demonstrated efficacy in managing gingivitis markers. Stannous fluoride has been shown to significantly reduce the Bleeding Index (BI) at both 12 and 24 weeks 14, while also improving Modified Gingival Index (MGI) scores 6. Triclosan-based formulations, including those combined with fluoride or copolymers, have demonstrated significant reductions in Gingival Index (GI), Prostaglandin E2 (PGE2), Interleukin-1 Beta (IL-β) 12, and Gingival Crevicular Fluid levels of IL-1 13. Triclosan/fluoride combinations also significantly improved both plaque and gingivitis scores [8, 9, 17].

Chlorhexidine Digluconate mouthwash was shown to significantly reduce the Gingival Severity Index (GSI) and overall Gingival Index 10. Mechanical interventions, such as specific dental flosses, were found to significantly reduce both interproximal and whole-mouth Modified Gingival Index scores compared to brushing alone 16. Additionally, certain dentifrices have shown significant improvements in plaque scores and gingivitis scores 4.

Recent results — preliminary, needs further review

  • Stannous fluoride toothpaste (Parodontax) significantly reduced the number of bleeding sites (NBS) at both 6 and 12 weeks compared to a negative control 2.
  • A test toothpaste showed a statistically significant reduction in Modified Gingival Index (MGI) at week 4, though it did not show significant differences in Bleeding Index or Number of Bleeding Sites compared to the control 3.

For the clinician treating this condition

  • Stannous fluoride and Triclosan-based formulations are established options for reducing gingival inflammation markers, including bleeding indices and inflammatory cytokines.
  • Chlorhexidine mouthwash is an established intervention for reducing Gingival Severity Index (GSI) and overall Gingival Index.
  • Mechanical interventions like specific dental flosses provide statistically significant reductions in Modified Gingival Index scores compared to brushing alone.

AI synthesis of 9 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
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