N/A
N=79
Gait Modification Treatment for Knee Osteoarthritis
Knee Osteoarthritis
Bottom Line
View on ClinicalTrials.gov: NCT02019108 ↗Enrolled (actual)
79
Serious AEs
0.0%
Results posted
Jul 2019
Primary outcome: Primary: Change From Baseline to Week 17 and From Baseline to Week 21 in Pain as Measured by Numerical Rating Scale — -2.1; -1.8; -2.2; -1.5 units on a scale — p=0.495
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Progressive walking program with toe-out gait modification (Other); Progressive walking program (Other)
- Age
- Adult, Older Adult · 50+ yrs
- Sex
- All
- Sponsor
- University of British Columbia
- Primary completion
- Oct 2017
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change From Baseline to Week 17 and From Baseline to Week 21 in Pain as Measured by Numerical Rating Scale |
-2.1; -1.8; -2.2; -1.5 | 0.495 |
| PRIMARY Change From Baseline to Week 17 and From Baseline to Week 21 in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain Subscale. |
-2.7; -1.5; -2.5; -1.5 | 0.117 |
| PRIMARY Change From Baseline to Week 17 and From Baseline to Week 21 in Knee Joint Loading: First Peak Knee Adduction Moment |
-0.01; 0.13; -0.06; 0.11 | 0.125 |
| PRIMARY Change From Baseline to Week 17 and From Baseline to Week 21 in Knee Joint Loading: Second Peak Knee Adduction Moment |
-0.24; 0.02; -0.19; 0.01 | <0.001 sig |
| PRIMARY Change From Baseline to Week 17 and From Baseline to Week 21 in Knee Joint Loading: Knee Adduction Moment Impulse |
-0.04; 0.01; -0.06; 0.00 | 0.031 sig |
| PRIMARY Change From Baseline to Week 17 and From Baseline to Week 21 in Foot Progression Angle (FPA) |
-8.87; 0.17; -6.96; -0.18 | <0.001 sig |
| SECONDARY Change From Baseline to Week 17 and From Baseline to Week 21 in Self-reported Physical Function as Measured by Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Physical Function Subscale. |
-11.4; -7.7; -9.4; -6.6 | 0.111 |
| SECONDARY Change From Baseline to Week 17 and From Baseline to Week 21 in Objective Physical Function as Measured by Timed Stair Climb. |
-0.16; -0.37; -0.44; -0.33 | 0.462 |
| SECONDARY Change From Baseline to Week 17 and From Baseline to Week 21 in Knee Joint Loading: Knee Flexion Moment |
0.06; 0.09; 0.31; 0.28 | 0.876 |
Summary
Knee osteoarthritis (OA) is a costly health condition affecting more than 10% of Canadian adults. Excessive and unbalanced loads passing through the knee joint have been implicated in the progression of OA. Typical conservative treatment of OA has focused on increasing daily activity, without consideration for the underlying joint loading. This study aims to compare a 4-month walking program that aims to increase the angle of the foot (toe-out angle) during walking - a measure shown to reduce joint loading and OA disease progression - while increasing walking time/distance, with a standard walking program that aims to increase walking time/distance. It is predicted that the walking program focusing on increasing toe-out will provide greater reductions in self-reported knee pain and a greater reduction in unfavorable knee joint loading.
Eligibility Criteria
Inclusion Criteria
- aged 50 years and older
- radiographically confirmed medial compartment tibia-femoral knee osteoarthritis
- available for weekly training sessions in the Vancouver British Columbia Canada region
- able to safely perform treadmill walking under therapist supervision
Exclusion Criteria
- articular cartilage degradation in the lateral tibiofemoral compartment greater than the medial
- inflammatory arthritic condition
- history of knee replacement or arthroscopic knee surgery
- recent use of corticosteroids (oral or via injection)
- inability to ambulate without a gait aid
- non-English speaking
- planning to commence a new treatment approach within the next 4 months
Data sourced from ClinicalTrials.gov (NCT02019108). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.