N/A N=11 Randomized Treatment

IVF Hyper-responders: Oocyte Vitrification Compared With Embryo Freezing

Infertility

Bottom Line

View on ClinicalTrials.gov: NCT02026193 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Jun 2015

Primary outcome: Primary: Fetal Heart Activity 1 Month Post Embryo Transfer — 0; 4 participants with fetal heart activity

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: oocyte vitrification (Procedure); embryo freezing (Procedure)
Age: Adult · 20+ yrs
Sex: Female
Sponsor: Rambam Health Care Campus
Primary completion: Nov 2014

Outcome Measures

Outcome	Result	p-value
PRIMARY Fetal Heart Activity 1 Month Post Embryo Transfer	0; 4	—

Summary

The chances to achieve pregnancy after retrieving >15 oocytes are not good, probably because of bad effect on the endometrium (uterine inner lining). Therefore, in most such cases the investigators prefer to freeze all embryos, and transfer in a thaw cycle. With the introduction of oocyte vitrification (very fast cooling) technology, a new option emerged: to freeze un-fertilized eggs, to be fertilized and used later in a thaw cycle. The purpose of this study is to compare the outcome of these two approaches.

Eligibility Criteria

Inclusion Criteria

IVF patients
ovulation trigger with Decapeptyl 0.2 mg because of ovarian hyper-response: E2 on trigger day .12,000 pmol/l and/or >15 oocytes.
Normal uterus

Exclusion Criteria

<20% fertilization rate

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT02026193). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.