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Home › Conditions › Infertility

Infertility

Subtypes of Infertility

Male Infertility 5 Diminished ovarian reserve 3 Asthenozoospermia 2

34 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Infertility

84 trials tracked for Infertility: 51 in phase 3 or 4 and 16 with published results. The most-cited published study has 540 citations.

84Trials tracked
51Phase 3 & 4
0Recruiting
16With published results
Phase distribution
Phase 4 27 Phase 3 24 Phase 2 6 Phase 1 2 Other / NA 25
  1. Phase 3 S0230 Goserelin in Preventing Ovarian Failure in Women Receiving Chemotherapy for Breast Cancer Completed · 540 cited
  2. Phase 3 Evidence-based Stimulation Trial With Human rFSH in Europe and Rest of World 1 Completed · 285 cited
  3. Phase 4 Safety and Efficacy of Pre-defined, Fixed Dose of Gonal-f Pen Based on Subject Baseline Characteristics in Subjects Undergoing in Vitro Fertilization (IVF) Completed · 120 cited
  4. Phase 4 Combined Letrozole and Clomid in Women With Infertility and PCOS Completed · 96 cited
  5. Phase 3 Phase 3 Study to Evaluate the Efficacy and Safety of Pergoveris® in Assisted Reproductive Technology (ESPART) Completed · 92 cited
  6. Phase 3 Efficacy and Safety of FE 999049 in Controlled Ovarian Stimulation in Japanese Women Completed · 69 cited
Show 44 more trials
  1. Phase 4 Effect of hCG on Receptivity of the Human Endometrium Completed · 65 cited
  2. Phase 4 MENOPUR® in a Gonadotropin-Releasing Hormone (GnRH) Antagonist Cycle With Single-Blastocyst Transfer in a High Responder Subject Population Completed · 50 cited
  3. Phase 4 Sonographic Hysterosalpingography: Oil vs Water Based Media (SHOW Trial) Completed · 47 cited
  4. Phase 4 Sexual Absorption of Vaginal Progesterone Completed · 40 cited
  5. Phase 3 Evidence-based Stimulation Trial With Human rFSH in Europe and Rest of World 2 Completed · 20 cited
  6. Phase 4 Endometrial Markers and Response of Endometriosis Patients to Prolonged GnRH Agonist Prior to IVF Completed · 19 cited
  7. Phase 4 Follicular Steroid Genesis in Controlled Ovarian Stimulation Completed · 10 cited
  8. Phase 3 Administration of Follicle-stimulating Hormone (FSH) and Low Dose Human Chorionic Gonadotropin (hCG) for Oocyte Maturity While Decreasing hCG Exposure in In Vitro Fertilization (IVF) Cycles Completed · 7 cited
  9. Phase 3 Recombinant FSH Investigation in the Treatment of Infertility With Assisted Reproductive Technology (ART) (RITA-1) Completed · 1 cited
  10. Phase 3 A Trial to Compare the Ovarian Response of REKOVELLE and GONAL-F in Conventional Dosing in Women Undergoing Controlled Ovarian Stimulation Completed
  11. Phase 4 Maximal Stimulation and Delayed Fertilization for Diminished Ovarian Reserve: a Randomized Pilot Study Completed
  12. Phase 4 A Non-inferiority Trial on Pain Relief During Oocyte Retrieval Completed
  13. Phase 4 FSH in GnRH-AntagoniST Controlled Ovarian Hyperstimulation Cycles (FAST) Completed
  14. Phase 4 RCT of Fixed vs Titrated Letrozole in Breast Cancer Patient Undergoing IVF Completed
  15. Phase 4 Ovulation Trigger With hCG Compared to GnRH Agonist in Patients With Repeated IVF Failures Completed
  16. Phase 4 Menopur Mixed Protocol Completed
  17. Phase 4 Predictive Factors for Ovarian Stimulation Using a Fixed Daily Dose of 200 IU Recombinant FSH (Study 142003)(P05696) Completed
  18. Phase 4 Menopur® Versus Follistim® in Polycystic Ovarian Syndrome (PCOS) Completed
  19. Phase 4 Use of High Cost Monitoring During Letrozole Ovulation Induction Completed
  20. Phase 4 Study to Examine Effect of Recombinant Luteinizing Hormone (r-Lh) and Recombinant Human Chorionic Gonadotropin (r-hCG) for Ovarian Stimulation in Assisted Reproduction Techniques (ART) Completed
  21. Phase 4 Progesterone Serum Levels in Subfertile Female Patients Undergoing in Vitro Fertilisation (IVF) Completed
  22. Phase 4 The Evaluation of Recombinant LH Supplementation in Patients With Suboptimal Response to Recombinant FSH Undergoing ICSI Completed
  23. Phase 4 CONSORT Randomized Controlled Trial in Assisted Reproductive Technology Completed
  24. Phase 4 MENOPUR® Versus FOLLISTIM® Completed
  25. Phase 4 The Influence of Adjuvant Medical Treatment of Peritoneal Endometriosis on the Outcome of IVF. A Prospective Randomized Analysis. Completed
  26. Phase 4 A Study of the Efficacy and Safety of Highly Purified Menotrophin Versus Recombinant Follitropin Alfa Completed
  27. Phase 4 Trial Comparing hCG Triggering Versus hCG Associated With GnRH Agonist Completed
  28. Phase 4 Comparison of Crinone 8% Intravaginal Gel and IM Progesterone Supplementation for In Vitro Fertilization (IVF) Completed
  29. Phase 4 Concomitant Administration of FSH With HCG Improves Oocyte Maturation and Quality Double -Blinded Randomized Trial Completed
  30. Phase 3 Multi-centre Study to Compare Efficacy and Safety of AFOLIA and Gonal-f in Women for Assisted Reproductive Treatment Completed
  31. Phase 3 Phase III Study Comparing Efficacy and Safety of AFOLIA vs Gonal-f® RFF in Women (35 to 42) Undergoing IVF Completed
  32. Phase 3 Convenience and Safety of Assisted Reproductive Technology Procedures Using a Gonal-F Filled by Mass (Fbm) Liquid Formulation Applied by Pen for Ovulation Induction and In-vitro Fertilization Completed
  33. Phase 3 A Randomised Trial Using Highly Purified Human Chorionic Gonadotropin (HP-hCG) and Recombinant Human Chorionic Gonadotropin (rhCG) in Women Undergoing Controlled Ovarian Stimulation Completed
  34. Phase 3 Comparison of MENOPUR Liquid and Powder in Women Undergoing Assisted Reproductive Technology (ART) Completed
  35. Phase 3 Efficacy and Tolerability of Human FSH Versus Recombinant FSH (Follitropin Alpha) in ICSI. Completed
  36. Phase 3 Frozen-thawed Embryo Transfer (FTET) Cycle Follow-up Protocol (P06031) Completed
  37. Phase 3 MENOPUR in Gonadotrophin-releasing Hormone (GnRH) Antagonist Cycles With Single Embryo Transfer Completed
  38. Phase 3 Efficacy Study of Granulocyte-macrophage Colony Stimulating Factor (GM-CSF) for Use in Human IVF Completed
  39. Phase 3 A Prospective Study to Evaluate the Addition of Subcutaneous Recombinant Human-Luteinizing Hormone With Recombinant Human-Follicle Stimulating Hormone on Follicular Development in Women Undergoing Ovarian Stimulation for Assisted Reproductive Technologies Completed
  40. Phase 3 SJ-0021 (Gonalef®) Versus Purified Pituitary Gonadotropin (Fertinorm-P®) for Ovulation Induction in Japanese Infertile Women Completed
  41. Phase 3 Safety and Efficacy Study in in Vitro Fertilisation (IVF) Patients Completed
  42. Phase 3 To Investigate Efficacy and Safety of a Single Injection of Org 36286 for Ovarian Stimulation Using Daily Recombinant FSH as Reference (Ensure)(P05690/MK-8962-001) Completed
  43. Phase 3 Does Endometrial Injury Improve Intrauterine Insemination Outcome? Completed
  44. Phase 3 Comparative Study Between Minidose Long Protocol and Microdose Flare Protocol in Controlled Ovarian Hyperstimulation Completed

Showing the 50 most-cited and recently-updated of 84 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Myo-inositol and clomiphene with sildenafil are associated with improved pregnancy outcomes in women with infertility
Diabetes & Endocrinology Meta-analysis
Myo-inositol and clomiphene with sildenafil are associated with improved pregnancy outcomes in women with infertility New findings show specific treatments may improve fertility outcomes
This meta-analysis evaluates various interventions for infertility, including hormonal therapies, ART strategies, and investigational adjunc…
Certain supplements and stress management programs show promise for women struggling with infertility, though more data is needed on safety.
Frontiers Jun 9, 2026
Leptin expression in seminal plasma is significantly higher in infertile patients with varicocele than controls
Urology Meta-analysis
Leptin expression in seminal plasma is significantly higher in infertile patients with varicocele than controls Infertile men with varicocele have higher leptin in their semen than healthy controls
This systematic review and meta-analysis examined leptin expression in seminal plasma and serum leptin levels in infertile patients with var…
A new analysis shows men with varicocele have significantly higher leptin in their semen. This finding might help explain why some struggle …
Frontiers Jun 7, 2026
Meta-analysis finds modest melanoma risk increase among infertile women using fertility treatments
Oncology Meta-analysis
Meta-analysis finds modest melanoma risk increase among infertile women using fertility treatments Fertility Drugs Linked to Slight Rise in Melanoma Risk
This systematic review and meta-analysis evaluated melanoma incidence in infertile women exposed to fertility treatments compared to untreat…
A large review finds fertility drugs may raise melanoma risk slightly, but the increase is small and more research is needed.
Jun 4, 2026
HA-ICSI may slightly reduce miscarriage risk in IVF, but live birth and pregnancy rates show little difference
OB/GYN & Women's Health Sys. Review
HA-ICSI may slightly reduce miscarriage risk in IVF, but live birth and pregnancy rates show little difference Advanced sperm selection shows mixed results for IVF success
This Cochrane systematic review of 5 RCTs with 3752 women found that HA-ICSI probably slightly decreases miscarriage risk compared to standa…
A review of trials finds one advanced sperm method may slightly lower miscarriage risk during IVF, but most techniques show uncertain benefi…
Cochrane Jun 2, 2026
Narrative review on semen and vaginal microbiota links to infertility outcomes
OB/GYN & Women's Health Sys. Review
Narrative review on semen and vaginal microbiota links to infertility outcomes Understanding how partner microbes might influence fertility outcomes for couples seeking treatment
This narrative mini review synthesizes evidence on semen and vaginal microbiota and couple-associated microbial patterns in infertility. The…
Current research suggests that microbes found in the vagina and on male genitals may play a role in fertility. However, scientists warn that…
Frontiers May 23, 2026
Case report on acupuncture for diminished ovarian reserve and recurrent IVF failure
Rheumatology Guideline
Case report on acupuncture for diminished ovarian reserve and recurrent IVF failure Acupuncture helps woman with low ovarian reserve get pregnant
This is a single case report describing acupuncture as adjunctive therapy for a patient with diminished ovarian reserve and recurrent IVF fa…
After three months of acupuncture, a 38-year-old with low ovarian reserve and failed IVF became pregnant. Hormones and egg count also improv…
Frontiers May 20, 2026
Narrative review explores nesfatin-1 in infertility, pregnancy, and lactation
Diabetes & Endocrinology Sys. Review
Narrative review explores nesfatin-1 in infertility, pregnancy, and lactation Nesfatin-1 May Explain Infertility, Pregnancy Problems, and Milk Supply
This narrative review examines the role of nesfatin-1 in infertility, pregnancy complications, and lactation. The authors find heterogeneous…
A body chemical called nesfatin-1 may tie together stress, metabolism, and fertility, offering clues for infertility, pregnancy problems, an…
Frontiers May 11, 2026
Narrative review explores potential links between BPA exposure and male infertility risks
OB/GYN & Women's Health Sys. Review
Narrative review explores potential links between BPA exposure and male infertility risks Plastic Chemicals May Hurt Male Fertility Through Gut Changes
This narrative review examines the association between transgenerational exposure to plastics-derived endocrine-disrupting bisphenol A and i…
New research suggests plastic chemicals might harm male fertility by altering gut bacteria and gene activity in ways that could last for gen…
Frontiers May 8, 2026
Systematic review of induction methods for pelvic inflammatory disease animal models
OB/GYN & Women's Health Sys. Review
Systematic review of induction methods for pelvic inflammatory disease animal models New animal models reveal hidden causes of pelvic pain
This systematic review evaluates various methods used to construct animal models for pelvic inflammatory disease. The authors categorize ind…
Chronic pelvic pain affects millions of women, and new research reveals how animal models are uncovering hidden triggers of pelvic inflammat…
Frontiers May 2, 2026
Umbrella review identifies risk factors and protective factors for male infertility and semen quality
Nutrition & Obesity Medicine Meta-analysis
Umbrella review identifies risk factors and protective factors for male infertility and semen quality New study lists many things that hurt male fertility and health
This umbrella review of 43 studies synthesizes evidence on risk factors for male infertility and abnormal semen parameters.
A new review shows that obesity, smoking, and certain illnesses can hurt sperm, but healthy habits might fix the problem.
May 1, 2026
Higher body mass index associated with increased oxidative stress in women undergoing IVF
OB/GYN & Women's Health Cohort
Higher body mass index associated with increased oxidative stress in women undergoing IVF Higher BMI linked to oxidative stress in infertility treatment
In this prospective observational cross-sectional study, researchers examined the relationship between body mass index and oxidative stress …
A new study shows that a higher BMI may trigger oxidative stress, a chemical imbalance that could impact women undergoing IVF.
Frontiers Apr 30, 2026
Large ART cohort shows clinical pregnancy rates around 34% and live birth rates near 25%
OB/GYN & Women's Health Cohort
Large ART cohort shows clinical pregnancy rates around 34% and live birth rates near 25% A new database reveals how IVF success rates vary across Europe
This retrospective observational cohort study analyzed 64,081 ovarian stimulation cycles from 18 IVF/ICSI centers in Italy and Germany.
This huge new database tracks real IVF cycles to help doctors understand current success rates and treatment patterns across Europe.
Frontiers Apr 30, 2026

Questions about Infertility

Can ultra-processed food consumption linked to obesity affect metabolic conditions in people with infertility?

Yes, ultra-processed food consumption is linked to obesity and can worsen metabolic conditions in people with infertility by increasing oxidative stress and inflammation.

Full answer →
Does taking Zishen Yutai Pill improve outcomes for patients undergoing IVF-ET for infertility?

Yes, a meta-analysis of 18 RCTs found Zishen Yutai Pill significantly improves clinical pregnancy and live birth rates in women undergoing IVF-ET.

Full answer →
How does having a higher body mass index affect oxidative stress during IVF for infertility?

Higher BMI increases oxidative stress during IVF by reducing antioxidant defenses and increasing lipid peroxidation, which may impair egg quality and treatment success.

Full answer →

All Infertility Articles