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N/A N=108 Randomized Triple-blind Supportive Care

Transversus Abdominis Plane Block Versus Local Anesthetic Infiltration for Pain Control in the Abdominal Surgery

Postoperative Pain

Enrolled (actual)
108
Serious AEs
0.0%
Results posted
Jun 2015
Primary outcome: Primary: Pain Score (NRS: Numerical Rating Scale) — 4.50; 4.81; 4.17 units on a scale

Study Design & Population

Study type
Interventional
Phase
N/A
Interventions
transversus abdominis plane block (Procedure); local infiltration (Procedure); Patient controlled analgesia (Procedure)
Age
Adult, Older Adult · 20+ yrs
Sex
All
Sponsor
Taipei Medical University Hospital
Primary completion
Apr 2014

Outcome Measures

OutcomeResultp-value
PRIMARY
Pain Score (NRS: Numerical Rating Scale)
4.50; 4.81; 4.17
PRIMARY
Opioid Consumption
27.69; 28.33; 21.53
SECONDARY
Sedation Scale
SECONDARY
Nausea and Vomiting Categorical Score
SECONDARY
Rescue Analgesic Use
SECONDARY
Rescue Antiemetics Use
SECONDARY
Time to the First Request of Analgesics
SECONDARY
Pruritus
SECONDARY
Quality of Recovery 40
SECONDARY
Heart Rate Variability
SECONDARY
Time to Flatus
SECONDARY
Length of Hospital Stay
SECONDARY
Number of Participants With Intervention-related Complication

Summary

Postoperative analgesia is an important part of the anesthetic care. According to the recent studies, multimodal analgesia can provide better analgesia & patient satisfaction with fewer side effect. For example, combining intravenous, intramuscular or oral analgesics with transversus abdominis plane (TAP) block or local anesthetic (LA) infiltration as the multimodal analgesia, can furnish a more effective pain control after the abdominal surgery. For abdominal surgery, both local infiltration and TAP block target on relieving somatic pain. Local anesthetic wound infiltration is easy to perform with low risk. As the advancement of ultrasound technology, performing the TAP block also becomes easier, safer and more accurate. But whether LA infiltration or TAP block is better for the multimodal analgesia regimen remains unclear. This study is to compare the postoperative pain score, opioid consumption, side effects, and quality of recovery between these two analgesic methods in patients undergoing abdominal surgery. The investigators hypothesized that TAP block may be more effective than LA infiltration as a part of the multimodal analgesia, and can improve the recovery after the abdominal surgery.

Eligibility Criteria

Inclusion Criteria

  • Adult (20~65y/o)
  • American Society of Anesthesiologists (ASA) physical status I~II
  • Patients scheduled for regular abdominal surgery under general anesthesia

Exclusion Criteria

  • ASA physical status ≥ 3
  • Allergy to morphine or local anesthetics
  • Morphine tolerance
  • Drug abuse or addiction
  • Bleeding tendency
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT02029755). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.

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