Phase 4
N=3
Ovulation Trigger With hCG Compared to GnRH Agonist in Patients With Repeated IVF Failures
Infertility
Bottom Line
View on ClinicalTrials.gov: NCT02048891 ↗Enrolled (actual)
3
Serious AEs
0.0%
Results posted
Jun 2015
Primary outcome: Primary: Fetal Heart Activity 1 Month After Oocyte Retrieval — 0; 0 participants with fetal heart activity
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 4
- Interventions
- GnRH agonist trigger (Drug); hCG trigger (Drug)
- Age
- Adult · 35+ yrs
- Sex
- Female
- Sponsor
- Rambam Health Care Campus
- Primary completion
- Jan 2015
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Fetal Heart Activity 1 Month After Oocyte Retrieval |
0; 0 | — |
| SECONDARY Patients Comfort During the Luteal Phase |
— | — |
Summary
Ovulation trigger is needed in in vitro fertilization (IVF) to get mature eggs. Routinely, human chorionic gonadotropin (hCG) is used for that purpose given its similarity to the natural hormone that does this job in a natural cycle (luteinizing hormone, LH). In a natural cycle another hormone takes part in the process (follicle stimulating hormone, FSH). To induce a natural-like ovulation surge that includes LH and FSH , gonadotropin releasing hormone (GnRH) agonist can be given.
The purpose of this study is to find out which approach may work better in IVF patients who experienced 4 IVF failures.
Eligibility Criteria
Inclusion Criteria
- IVF patients with at least 4 consecutive failures.
- On trigger day, no more than 10 follicles of 12 mm and up
Exclusion Criteria
- History of moderate or severe OHSS.
Data sourced from ClinicalTrials.gov (NCT02048891). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.