N/A
Completed N=33
Developing Effective Response Inhibition Training for Symptom Relief in OCD and Trichotillomania
Obsessive-compulsive disorder · Trichotillomania
Source: ClinicalTrials.gov NCT02059980 ↗
Enrolled (actual)
33
Serious AEs
0.0%
Results posted
Sep 2018
Primary outcomePrimary: Composite Score of Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) and National Institute of Mental Health (NIMH) — -.38; .46; -.89; -.52 z scores — p== 0.56
Summary
Obsessive-compulsive disorder (OCD) and its related disorders (e.g., trichotillomania) are characterized by the marked difficulty in inhibiting unwanted or inappropriate responses. There is compelling evidence that poor response inhibition is a core cognitive feature of OCD and its related disorders, but no effective intervention exists that directly attempts to address this problematic cognitive deficiency. This study will examine the feasibility and clinical utility of a computerized cognitive training program designed to improve response inhibition among individuals diagnosed with OCD or trichotillomania.This training program offers systematic practice of response inhibition in the form of a 40-level computer game. Individuals with these conditions will be randomized to either 8 sessions of (a) computerized response inhibition training (RIT) or (b) placebo computer training (PLT). We hypothesize that RIT will outperform PLT in improving response inhibition capabilities and reducing relevant clinical symptoms. In sum, this project is expected to generate important knowledge to guide the development of effective computer-based treatment approaches that may help reduce critical problems of existing treatments such as suboptimal patient retention and treatment under-utilization, thereby improving overall treatment response rates among individuals suffering from OCD and related conditions.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Composite Score of Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) and National Institute of Mental Health (NIMH) |
-.38; .46; -.89; -.52; -1.20; -.71 | = 0.56 |
| PRIMARY Stop Signal Reaction Time |
225.47; 225.83; 215.68; 212.92; 211.46; 208.69 | =.98 |
| SECONDARY Clinical Global Impression Severity and Improvement |
3.67; 4.00; 3.63; 3.57; 3.20; 3.69 | — |
| SECONDARY Commission Errors on the Go/No-go Task. |
10.41; 9.40; 10.69; 15.64; 9.38; 11.77 | — |
Eligibility Criteria
Inclusion Criteria
- Principal diagnosis of obsessive-compulsive disorder or trichotillomania
Exclusion Criteria
- Current substance use problems
- Current/Past Psychotic disorder, bipolar disorder, or schizophrenia
- Attention deficit/hyperactivity disorder or tic disorder
- Severe depressive symptoms
- Current psychotherapy
- Current suicidality
- Estimated intellectual functioning < 80
- Lack of response inhibition deficits on a stop-signal task
Data sourced from ClinicalTrials.gov (NCT02059980). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.