Phase 4
Completed N=22
Antitussive Effect of a Naturally Flavored Syrup Containing Diphenhydramine, Compared With Dextromethorphan and Placebo
Cough Reflex Sensitivity
Source: ClinicalTrials.gov NCT02062710 ↗
Enrolled (actual)
22
Serious AEs
0.0%
Results posted
Apr 2015
Primary outcomePrimary: Change in Cough Reflex Sensitivity to Capsaicin — 0.97; 0.80; 0.57 log C5 (uM)
Summary
The purpose of this study is to evaluate the antitussive (cough-suppressing) effects of two liquid medications: a combination of diphenhydramine and phenylephrine in a naturally cocoa flavoring, and, dextromethorphan syrup, compared with placebo.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Cough Reflex Sensitivity to Capsaicin |
0.97; 0.80; 0.57 | — |
Eligibility Criteria
Inclusion Criteria
- healthy adult nonsmokers
- onset of acute, viral upper respiratory tract infection (common cold) within 72 hours of enrollment
Exclusion Criteria
- smokers
- history of asthma or other respiratory disorders
Data sourced from ClinicalTrials.gov (NCT02062710). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.