Phase 4 N=30 Effect of Electronic Cigarette Use on Cough Reflex Sensitivity
Cough
Primary: Change in Cough Reflex Sensitivity (Log C5) — -0.29; 0.24 log C5
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Early Phase 1 N=19 Cough Desensitization Therapy for Cough Hypersensitivity Syndrome
Cough
Primary: Leicester Cough Questionnaire (LCQ) — 3.2; 2.06 score on a scale — p=.23
N/A N=15 Assessment of Cough Reflex in Lung Transplant Recipients
Complication of Transplanted Lung
Primary: Number of Coughs — 7.3 Coughs — p=<0.01
Early Phase 1 N=5 The Effects of Tiotropium on the Cough Reflex in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Chronic Obstructive Pulmonary Disease · Chronic Bronchitis
Primary: Number of Coughs Following Capsaicin Inhalation Challenge at Baseline and Following 30 Days of Treatment With Spiriva (Baseline and 30 Days) — 2.5 coughs per dose of…
Phase 2 N=25 Respiratory Kinematics During Voluntary and Reflex Cough in Healthy Adults
Cough
Primary: Lung Volume Initiation — 23.3 % Vital Capacity, relative to EEL
N/A N=131 ATP Level and Cough Sensitivity to ATP in Subjects With Refractory/Unexplained Chronic Cough
Refractory/Unexplained Chronic Cough
Primary: ATP Level in Sputum Supernatant — 2313.4; 1804.6 pM
Phase 2 N=50 Effect of Gefapixant (AF-219/MK-7264) on Cough Reflex Sensitivity (MK-7264-015)
Refractory Chronic Cough
Primary: Cough Reflex Sensitivity to Capsaicin Measured by Maximal Cough Response (Emax) — 4.14; 4.14; 7.57; 3.66 Emax (Explosive coughs/15 sec) — p=< 0.0001
Phase 4 N=30 Mepolizumab for the Treatment of Chronic Cough With Eosinophilic Airways Diseases
Chronic Cough · Eosinophilic Bronchitis · Asthma
Primary: Change From Baseline in 24-hour Cough Frequency at 14 Weeks — 17.0; 17.0; 12.6; 10.6 Coughs/hour — p=0.99
N/A N=58 Functional Magnetic Resonance Imaging of ATP Cough in Chronic Cough Patients
Cough
Primary: Brainstem Neural Activations to Capsaicin — 0.09; 0.39; -0.14; 0.44 Percentage change in BOLD signal — p==0.0028
Phase 2 N=36 Effect of Gefapixant (MK-7264/AF-219) on Cough Reflex Sensitivity in Healthy and Chronic Cough Participants (MK-7264-014)
Refractory Chronic Cough
Primary: Cough Reflex Sensitivity to Capsaicin in Participants Who Received Gefapixant 100 mg and Placebo (Period 1 & Period 2 Combined) — 3.05; 3.04; 1.72; 1.41 natural log (µM)…
Phase 2 N=16 GSK2339345 Hypertussive Challenge Study
Cough
Primary: Total Cough Count Over 8 Hours at Visits 1, 2 and 3 (Part A) — 152.7; 192.5 cough count
Phase 2 N=44 Respiratory Kinematics of Cough in Healthy Older Adults and Parkinson's Disease
Cough · Parkinson's Disease
Primary: Peak Expiratory Flow Rate — 4.34; 3.92 Liters of air/second
N/A N=6 Sub-study to Spinal Cord Stimulation to Restore Cough
Spinal Cord Injuries · Spinal Cord Diseases · Paralysis
Primary: The Effects of Electrical Spinal Cord Stimulation (SCS) on Airway Pressure Generation While Using Temporarily Placed Parallel Wire Leads and Implanted Disc Electrodes…
N/A N=17 Spinal Cord Stimulation to Restore Cough
Spinal Cord Injuries · Spinal Cord Diseases · Paralysis
Primary: Effectiveness of Expiratory Muscle Activation to Generate Large Airway Pressures Characteristic of Normal Cough. — 25; 121 cmH2O — p=<0.05
Phase 3 N=17 Efficacy of SLN Block for Chronic Cough
Cough · Superior Laryngeal Nerve Block · Neurogenic Cough
Primary: Change in Cough Severity — 13.15; 9.54 LCQ scores (baseline to 3 months)
N/A N=265 Study of Count Coughs in Subjects With Acute Upper Respiratory Tract Infections
Infection
Primary: Number of Cough Bouts Over 4-hour Postdose Period — 139.6; 131.3; 126.4 Cough bouts — p=0.216
Phase 2 N=185 Study of the Efficacy, Safety, and Tolerability of Serlopitant for the Treatment of Refractory Chronic Cough
Refractory Chronic Cough
Primary: Change in 24-hour Objective Cough Frequency (Log Normalized Percent Change Relative to Placebo) — -0.18; -0.45 coughs/hr — p=0.9942
Phase 2 N=66 Refractory Chronic Cough Improvement Via NAL ER (RIVER)
Refractory Chronic Cough
Primary: Relative Change From Baseline in 24-hour Cough Frequency at Day 21 — -64.92; -9.36 coughs per hour — p=<0.0001
Phase 2 N=406 Evaluation of S-600918 in Adults With Refractory Chronic Cough
Chronic Cough
Primary: Percent Change in Number of Coughs Per Hour in 24 Hours Following 4 Weeks of Study Treatment — -55.16; -61.08; -65.32; -60.38 percentage change — p=0.9334
N/A N=39 Internet-Behavioral Cough Suppression Therapy
Cough · Chronic Disease
Primary: Leicester Cough Questionnaire — 9.04; 8.86; 12.78; 9.44 Total LCQ Score — p=.014
Phase 2 N=310 Clinical Study to Evaluate the Efficacy and Safety of Three Different Doses of BAY1817080 Compared to Placebo in Patients With Chronic Cough
Refractory and/or Unexplained Chronic Cough
Primary: Change From Baseline in 24-hour Cough Count After 12 Weeks of Intervention — 0.56; 0.47; 0.52; 0.64 Ratio btw geoMeans of 24h cough count — p== 0.0345
Phase 2 N=51 A Clinical Trial to Evaluate the Safety and Efficacy in Subjects With Chronic Cough
Chronic Cough
Primary: Number of Subjects With Serious Adverse Events — 0; 0 Participants
Phase 4 N=150 Comparison of Efficacy and Tolerability of Two Cough Syrups in Cough Due to Cold in Children.
Cough · Upper Respiratory Tract Infection
Primary: Change in Night Cough Score on First Night of Treatment (From N0 to N1) — -5.16; -1.77 change in combined night cough score — p=<0.01
N/A N=61 A Cross-sectional Study to Measure Cough in Severe Asthma
Asthma · Cough
Primary: Cough Frequency Measurement — 6.6; 2.7; 2.5; 12.7 coughs per hour over a 24 hour monitorin
Phase 4 N=269 BENEFITS OF ACLIDINIUM BROMIDE IN THE RELIEF OF COPD SYMPTOMS INCLUDING COUGH
Pulmonary Disease, Chronic Obstructive
Primary: Change From Baseline in Overall Exacerbations of Chronic Pulmonary Disease Tool-Respiratory Symptoms (E-RS) Total Score Over the 8 Week Study Period — -1.75; -0.73 Score…
Phase 4 N=142 Effect of Single-dose Dexmedetomidine on Airway Reflex in Adult With Oral Intubation After Thyroidectomy
Coughing
Primary: Coughing Grade — 0.6; 1.4 units on a scale
N/A N=12 Stimulation With Wire Leads to Restore Cough
Spinal Cord Injuries · Spinal Cord Diseases · Paralysis
Primary: Measurements of Peak Expiratory Airflow Rate to Evaluate Efficacy of Cough. — 2.1; 9.6; 10.4; 11.1 L/s — p=<0.05
Phase 2 N=14 Cough and Swallow Rehab Following Stroke
Ischemic Stroke
Primary: Maximum Expiratory Pressure — 104.31 cm H2O (pressure measurement) — p=.001
Phase 2 N=253 A 12-Week Study in Participants With Refractory Chronic Cough (MK-7264-012)
Refractory Chronic Cough
Primary: Change From Baseline in Awake Objective Cough Frequency After 12 Weeks of Treatment (Day 84) — -0.40; -0.64; -0.65; -0.86 log coughs/hour — p=0.0971
N/A N=22 Sham CPAP vs. Straight CPAP for Chronic Cough
Chronic Cough · OSA
Primary: Change in Leicester Cough Questionnaire Score — 6.61; 2.07 score on a scale