Phase 4
Completed N=72
LIPT - Liraglutide in Polycystic Ovary Syndrome
Source: ClinicalTrials.gov NCT02073929 ↗Enrolled (actual)
72
Serious AEs
4.2%
Results posted
Feb 2019
Primary outcomePrimary: Change in Endogenous Thrombin Potential (ETP) — -56.7; -8.2 nMolar x minutes
◆ Published Evidence
Highly cited
165citations · ~21 / year
Effect of liraglutide on ectopic fat in polycystic ovary syndrome: A randomized clinical trial.
Summary
Polycystic ovary syndrome (PCOS) affects 5-10% of women in fertile age. PCOS is associated with metabolic syndrom, diabetes and and increased risk og cardiovascular disease.
The study investigates the effect af intervention with GLP-1-analog on risk markers of cardiovascular disease in women with PCOS.
70 women will be included in af RCT.
Hypothesis: GLP-1-analog treatment in women with PCOS (without diabetes) will result in a beneficial reduction in risk markers of vascular thrombosis and early cardiovascular disease.
Linked Publications
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Effect of liraglutide on ectopic fat in polycystic ovary syndrome: A randomized clinical trial.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Endogenous Thrombin Potential (ETP) |
-56.7; -8.2 | — |
| SECONDARY Percent Change in Plasma Level of Plasminogen Activator Inhibitor -1 PAI-1 |
-12; 4 | — |
Eligibility Criteria
Inclusion Criteria
- PCOS
- >18 years
- premenopausal
- BMI >25 og 25 and thereunder + insulin resistent
Exclusion Criteria (including):
- actualt or intended pregnancy
- inadeqvat contraception
- hormonal contraception within 6 weeks
- metfoomin, GLP-1-analog or DPP IV inhibitor within 3 months
- medications affectiv hemostatic mechanisme
- diabetes or other severe comorbidity
- familar MEN
- ...
Data sourced from ClinicalTrials.gov (NCT02073929) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.