Phase 3
Completed N=903
Study of Tranexamic Acid During Air and Ground Medical Prehospital Transport Trial (STAAMP Trial)
Source: ClinicalTrials.gov NCT02086500 ↗Enrolled (actual)
903
Serious AEs
1.2%
Results posted
Sep 2020
Primary outcomePrimary: 30 Day Mortality — 36; 45 Participants
◆ Published Evidence
Highly cited
121citations · ~20 / year
Tranexamic Acid During Prehospital Transport in Patients at Risk for Hemorrhage After Injury: A Double-blind, Placebo-Controlled, Randomized Clinical Trial.
Summary
The purpose of this study is to determine if 1 gram of prehospital tranexamic acid given during emergency medical transport to a level 1 trauma center in patients at risk of hemorrhage is associated with lower 30 day mortality.
Linked Publications (3)
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Tranexamic Acid During Prehospital Transport in Patients at Risk for Hemorrhage After Injury: A Double-blind, Placebo-Controlled, Randomized Clinical Trial.
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Prehospital tranexamic acid is associated with a dose-dependent decrease in syndecan-1 after trauma: A secondary analysis of a prospective randomized trial.
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Characterization of adverse events in injured patients at risk of hemorrhagic shock: a secondary analysis of three harmonized prehospital randomized clinical trials.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY 30 Day Mortality |
36; 45 | — |
| SECONDARY 24 Hour Mortality |
16; 17 | — |
| SECONDARY Acute Lung Injury |
42; 39 | — |
| SECONDARY Multiple Organ Failure |
33; 39 | — |
| SECONDARY Nosocomial Infection |
88; 66 | — |
| SECONDARY 24 Hour Total Blood Transfusion |
0; 0 | — |
| SECONDARY Hyperfinbrinolysis |
145; 144 | — |
Eligibility Criteria
Inclusion Criteria
- Blunt or penetrating injured patients at risk of bleeding being transported via air or ground medical services from the scene of injury or from referring hospital to a definitive trauma center that is participating in the trial AND
- Within 2 hours of time of injury AND
- Hypotension (Systolic Blood Pressure (SBP) 110 beats per minute)
- At scene of injury or during air or ground medical transport
- Documented at referring hospital prior to air or ground medical transport arrival
Exclusion Criteria
- Age > 90 or 5 minutes CPR without return of vital signs
- Penetrating cranial injury
- Traumatic brain injury with brain matter exposed
- Isolated drowning or hanging victims
- Wearing an opt out bracelet.
- Isolated fall from standing
- Patient or Family Objection at scene
Data sourced from ClinicalTrials.gov (NCT02086500) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.