N/A N=1,051 Shock, Whole Blood, and Assessment of TBI S.W.A.T. (LITES TO 2)
Hemorrhagic Shock · Traumatic Brain Injury
Primary: 4 Hour Mortality — 50; 32 Participants
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=5 Biological Response of Trauma Patients to Standard Trauma Resuscitation Therapy
Hemorrhagic Shock
Primary: Biological Response as Characterized by Selected Cytokines, Specifically Tumor Necrosis Factor Alpha (TNFα), Interleukin One (IL-1β), and Interleukin Six (IL-6).
Phase 2 N=191 Field Trial of Hypotensive Versus Standard Resuscitation for Hemorrhagic Shock After Trauma
Blunt Trauma · Penetrating Wound · Hemorrhagic Shock
Primary: Total Volume of All Crystalloid Given for Early Resuscitation (Feasibility) — 2.04; 1.04; 1 liters
Phase 2 N=31 Traumatic Injury Clinical Trial Evaluating Tranexamic Acid in Children: A Pilot and Feasibility Study
Brain Injuries · Wounds and Injuries · Hemorrhage
Primary: Pediatric Quality of Life Inventory (PedsQL) — 64.9; 60.2; 67.2 Quality of life units * months
N/A N=50 Effect of Remote Ischemic Conditioning on Trauma Patients With Hemorrhagic Shock
Hemorrhagic Shock
Primary: Neutrophil Oxidative Burst Activity — 302; 302; 298; 268 Median Fluorescence Intensity — p=0.56
Phase 3 N=199 Low-Titer O Positive Whole Blood Versus Component Therapy for Emergent Transfusion in Trauma Patients
Hemorrhagic Shock · Acute Blood Loss Anemia · Traumatic Brain Injury
Primary: Packed Red Blood Cells Equivalents Units Transfused (1 Whole Blood Unit Treated as 1 Packed Red Blood Cell Unit and 1 Fresh Frozen Plasma Unit) — 3.8; 5.7 units
Phase 4 N=107 Early Whole Blood in Patients Requiring Transfusion After Major Trauma
Trauma/Injury Problem
Primary: Units of Blood Products Required During the First 24 Hours After Emergency Department Admission — 12; 13 units of blood
N/A N=50 Pre-hospital Advanced Therapies for Control of Hemorrhage - Pelvis
Hemorrhage · Pelvic Fracture
Primary: Mortality Rate — 0; 1 Participants
Phase 4 N=100 ORthopaedic Trauma Anemia With Conservative Versus Liberal Transfusion
Anemia
Primary: Postoperative Wound Infection (Superficial or Deep) or Other Perioperative Infection — 12; 3 Participants — p=.0122
N/A N=1,714 Use of Hextend in Trauma
Trauma
Primary: Mortality — 42; 81 participants
N/A N=380 Evaluation of Non-Invasive Hemoglobin in Trauma Patients
Trauma
Primary: SpHb's Ability to Detect Critical Drops
Phase 2 N=101 AVERT Shock: Arginine Vasopressin During the Early Resuscitation of Traumatic Shock
Traumatic Shock
Primary: Number of Blood Products Transfused — 1.7; 3.0 Litre
N/A N=119 Optimal Fluid Resuscitation for Trauma Patients
Trauma
Primary: Mortality — 0 participants
N/A N=114 Comparison of Rapid Thrombelastography and Conventional Coagulation Testing for Haemostatic Resuscitation in Trauma
Acute Coagulopathy
Primary: 28 Day In-hospital Mortality — 20; 11 participants — p=0.04
Phase 3 N=1,604 Early Use of Cryoprecipitate With Major Hemorrhage Protocol (MHP) Activation
Trauma Injury
Primary: Number of Participants With Mortality From Any Cause — 201; 192 Participants
Phase 3 N=523 PreHospital Air Medical Plasma Trial
Hemmorhagic Shock During Air Medical Transport
Primary: Our Primary Outcome for the Proposal Will be 30 Day Mortality — 53; 89 Participants
Phase 2 N=1,063 Prehospital Tranexamic Acid Use for Traumatic Brain Injury
Traumatic Brain Injury
Primary: Dichotomized Glasgow Outcome Scale Extended (GOS-E) at 6 Months — 107; 108; 110; 218 Participants — p=.1809
Phase 2 N=150 Tranexamic Acid Mechanisms and Pharmacokinetics in Traumatic Injury
Hemorrhage · Shock · Wounds and Injuries
Primary: Change in HLA-DR Expression on Monocytes 72 Hours After Drug or Placebo Administration in Patient Groups (0g TXA (Placebo); 2g TXA; 4g TXA)." — 0.503; 0.509; 0.532 fold…
Phase 2 N=100 The Effect of Tranexamic Acid on Postpartum Hemorrhage During and After Cesarean Delivery
Hemorrhage
Primary: The Amount of Hemorrhage During Cesarean Delivery and Within 2 Hours Afterward — 260; 380 ml
Phase 2 N=50 Resuscitative Endocrinology: Single-dose Clinical Uses for Estrogen-Traumatic Hemorrhagic Shock (RESCUE - Shock)
Hemorrhagic Shock
Primary: Survival — 16; 21 participants — p=.252
N/A N=258 HEMOBLAST Pivotal Clinical Investigation
Hemostasis
Primary: Proportion of Subjects Achieving Hemostasis — 148; 61 Participants — p=<0.0001
Phase 2 N=128 Does Early Administration of Tranexamic Acid Reduce Blood Loss and Perioperative Transfusion Requirement
Hip Fractures · Intertrochanteric Fractures
Primary: Number of Subjects Transfused at Least 1 Unit of Packed Red Blood Cells — 17; 19 Participants
N/A N=4 Temporary Aortic Occlusion With the Abdominal Tourniquet for Refractory Postpartum Haemorrhage: A Proof-of-Concept Study in a War-Affected Region
Postpartum Haemorrhage (PPH)
Primary: Time to Bleeding Control After AAJT-S Device Application — 2 Minutes
Phase 2 N=200 Cold Stored Platelet in Hemorrhagic Shock
Trauma · Hemorrhage
Primary: Study Feasibility — 91; 82 Participants
Phase 2 N=50 Resuscitative Endocrinology:Single-dose Clinical Uses for Estrogen-Traumatic Brain Injury
Traumatic Brain Injury
Primary: Percent Passing the Galveston Orientation Amnesia Test (GOAT) Within 28 Days Post Injury — 12; 14 Participants — p=0.99
Phase 4 N=437 Fibrinogen in Haemorrhage of Delivery
Post-Partum Hemorrhage
Primary: Failure Rate of PPH Management — 75; 80; 92; 92 Participants — p=0.9563
N/A N=1,439 Epidemiology of Severe Peroperative Bleeding During Scheduled Surgery
Surgery · Blood Loss
Primary: Unanticipated Bleeding — 0; 100; 0 percentage of participants
Phase 4 N=10 Performance of Junctional Tourniquets in Normal Human Volunteers
Hemorrhage
Primary: Effectiveness at Stopping Distal Pulse — 97; 27; 83; 93 percentage of participants
Phase 1 N=62 Delayed Versus Early Enoxaparin Prophylaxis After Traumatic Brain Injury (TBI)
Venous Thromboembolism · Traumatic Brain Injury
Primary: Percentage of Participants With Worsening TBI Hemorrhage — 5.9; 3.6 percentage of participants
Phase 3 N=903 Study of Tranexamic Acid During Air and Ground Medical Prehospital Transport Trial (STAAMP Trial)
Traumatic Hemorrhage
Primary: 30 Day Mortality — 36; 45 Participants