N/A N=32 Randomized Treatment

Heated Humidified Oxygen Compared to Dry Oxygen Therapy in Children With Bronchiolitis

Bronchiolitis · Hypoxemia

Bottom Line

View on ClinicalTrials.gov: NCT02094664 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Jan 2018

Primary outcome: Primary: Change in Respiratory Distress Assessment Instrument (RDAI) From Baseline. — 4.69; 2.69; 4.27; 3 units on a scale

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Heated and humidified oxygen (Device)
Age: Pediatric
Sex: All
Sponsor: UCSF Benioff Children's Hospital Oakland
Primary completion: Jun 2015

Outcome Measures

Outcome	Result	p-value
PRIMARY Change in Respiratory Distress Assessment Instrument (RDAI) From Baseline.	4.69; 2.69; 4.27; 3; 4.33; 3.44	—
PRIMARY Change in Respiratory Rate (RR) From Baseline	45.44; 48.19; 44.81; 45.81; 45.73; 47.25	—
SECONDARY Length of Hospital Stay	4.44; 4.56	—
SECONDARY Duration of O2 Use	60.02; 72.11	—

Summary

The purpose of this study is to compare heat and humidified oxygen with cold and dry oxygen in children with bronchiolitis. The hypotheses are that heating and humidifying inspired low flow supplemental oxygen will optimize mucociliary function thereby, 1) improve oxygenation, 2) decrease work of breathing, and 3) decrease length of hospital stay.

Eligibility Criteria

Inclusion Criteria

Ages ≤24 months of age
Physician diagnosed bronchiolitis
Admitted to pediatric floor
Supplemental oxygen requirement, <4 L/min, for hypoxemia, oxygen saturation <92% in room air

Exclusion Criteria

Prematurity, born <37 weeks gestational age
Admitted to pediatric intensive care unit for medical indication
Requirement of heated, humidified high flow system
Chronic lung disease (such as bronchopulmonary dysplasia, cystic fibrosis, primary ciliary dyskinesia, tracheostomy status, baseline oxygen requirement)
Neuromuscular disorders
Chromosomal defects
Metabolic disorders
Immunodeficiency
Unrepaired cardiac abnormalities

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT02094664). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.