N/A N=33 Randomized Single-blind Other

Strength Training and Endurance Exercise for LIFE

HIV

Bottom Line

View on ClinicalTrials.gov: NCT02101060 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

May 2021

Primary outcome: Primary: Aerobic Capacity — 0.15; 0.02 Liters/minute

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: exercise (Other)
Age: Adult, Older Adult · 50+ yrs
Sex: All
Sponsor: VA Office of Research and Development
Primary completion: Oct 2019

Outcome Measures

Outcome	Result	p-value
PRIMARY Aerobic Capacity	0.15; 0.02	—
PRIMARY Diastolic Function	1.8; 0.5	—
SECONDARY Biomarkers of Systemic Inflammation	-0.04; -0.03	—

Summary

Research is needed to determine safe and effective exercise rehabilitation programs to prevent and improve physical disability in older adults living with HIV. This problem is of great importance to the VA. The majority of the 25 thousand HIV-infected veterans are over 50 years of age (64%). The combined effect of aging and inflammation increase the risk for physical disability in older HIV-infected veterans. This translational exercise training trial will examine the cardiac and skeletal muscle effects of combined aerobic exercise and resistance training to attenuate the functional declines of aging with HIV by reducing the deleterious consequences of chronic inflammation. Findings will guide future rehabilitation research on cardiac remodeling and inflammation of skeletal muscle. The proposed research will advance the goal to develop effective rehabilitation strategies that improve the health of older HIV-infected veterans.

Eligibility Criteria

Inclusion Criteria

HIV-infected veterans adult 50 years of age and older under medical care for HIV
Antiretroviral Therapy

Exclusion Criteria

Patients with comorbid conditions that could have a potential impact on their ability to perform exercise testing and training will be excluded according to the American College of Sports Medicine
Only sedentary adults will be eligible. Individuals that participate in regular structured aerobic exercise or resistance training in the prior 6-months will be excluded

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT02101060). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.